Abstract: An implantable device for controlling electrical conditions of body tissue. A feedback sense electrode and a compensation electrode are positioned proximal to the tissue to make electrical contact with the tissue. A feedback amplifier is referenced to ground, and takes as an input a feedback signal from the feedback sense electrode. The output of the feedback amplifier is connected to the compensation electrode. The feedback amplifier thus drives the neural tissue via the compensation electrode in a feedback arrangement which seeks to drive the feedback signal to ground, or other desired electrical value.

Abstract: A biopsy needle assembly includes a mandrel within a cannula, the needle assembly is fired into a target tissue to obtain a tissue sample using a force source imparting movement to the needle assembly. The mandrel and cannula design, and force source characteristics minimize needle deflection, and allow the needle assembly to excise extended length tissue samples. The mandrel forms tissue retention ridges within a tissue sample region to reduce fragmentation of the tissue sample.

Abstract: Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.

Abstract: Systems and techniques are disclosed for decoupling a wearable sensor's location on a user from the body movements desired to be measured by the sensor. Sensor data can be dynamically analyzed to determine a reference event (e.g., a static pose), which can be used to generate or update a transformation parameter (e.g., a quaternion or a rotational matrix). The transformation parameter can be applied to sensor data to transform the sensor data from the sensor's frame of reference to a global frame of reference. Once transformed, the movement data in the global frame can be analyzed to identify sensor-location-agnostic biomechanical features (e.g., body movements or movement trends), which can be further analyzed to identify probable or potential diagnoses correlated with the identified biomechanical features.

Abstract: Apparatus and methods are described including apparatus for monitoring a female subject that includes a sensor, configured to monitor the subject without requiring compliance of the subject, and to generate a sensor signal in response to the monitoring. A computer processor is configured to receive the sensor signal, analyze the sensor signal, in response to the analyzing, identify whether the subject is in a pregnant state or a non-pregnant state, and generate an output in response thereto. Other applications are also described.

Abstract: The present invention provides objective methods of diagnosis and behavioral treatments of neurological disorders such as autism spectral disorders and Parkinson's disease.

Abstract: Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature. In at least one embodiment, the elongated body is configured as a stylet. In another embodiment, techniques for identifying and locating obstructions in the vessel in which a device is disposed are disclosed.

Abstract: A motion analysis system includes: at least one orientation sensor configured to detect three-dimensional torso motion over time, the at least one orientation sensor including: a multiaxial accelerometer configured to detect acceleration in at least three orthogonal directions, and a gyroscope; and a controller configured to receive data from the at least one orientation sensor, the controller programmed to process the data to: determine at least one of a state and a transition of the torso; identify normal parameters for the determined at least one of the state and transition; and determine whether motion of the torso is outside the normal parameters. The controller is configured to identify, in real-time, the occurrence of a fall in progress of an individual from at least one of a standing state, a standing-to-seated transition, and a seated-to-standing transition.

Abstract: A method of operating a computational device to process patient sounds, the method comprises the steps of: extracting features from segments of said patient sounds; and classifying the segments as cough or non-cough sounds based upon the extracted features and predetermined criteria; and presenting a diagnosis of a disease related state on a display under control of the computational device based on segments of the patient sounds classified as cough sounds.

Abstract: Embodiments of the invention include an endoscope including multiple lumens for tissue acquisition and removal and related methods of use.

Abstract: A medical device for monitoring physical, chemical, or biological characteristics of an organ, such as the urinary bladder. The medical device may include an elongate member having a proximal end and a distal end. The device may further include an end-effector assembly extending distally from the distal end of the elongate member. The end-effector assembly may also include a plurality of sensing elements for detecting abnormal organ function. Each of the plurality of sensing elements may include one or more of mechanical, visual, chemical, and biological sensors.

Abstract: Embodiments of the present disclosure provide systems and methods for monitoring a patient to produce a signal representing a blood oxygen concentration. The signal may be analyzed to determine the presence of one or more sleep apnea events, and an integral of the signal may be calculated if the signal is outside of a set range or threshold. A practitioner may choose to be informed of the presence of sleep apnea events if the blood oxygen concentration is less then a preset limit, if an upper limit has been reached for an integral representing the severity of the oxygen deprivation over time, or anytime sleep apnea events may be present in the signal.

Abstract: A method and apparatus for the detection of the onset of hypoglycaemia is described. A portable sensor worn by a subject is used to detect a physiological tremor signal. The tremor signal is analysed over a period of time, and an alarm is generated when a change in the physiological tremor signal indicative of the onset of hypoglycaemia in the subject is detected. A patient or carer can then perform appropriate action, such as performing a finger prick test to determine blood sugar test and treating as required. The portable sensor can be used to detect a tremor signal indicative of the, the onset of hypoglycaemia such as a signal corresponding to a decrease in blood glucose level (BGL) below 5 mmol/l. The portable sensor can use an accelerometer and may be worn on a limb, such as an arm or leg. The sensor can be used to measure the power of the tremor signal and detect a change, such as an increase in power over time and/or an increase in the rate of change of power over time.

Abstract: Methods and devices for holding liquid or solid materials including a cylindrical container, a holder, and a detachable handle, the handle capable of being adjusted to variable angles when coupled to the holder. Method of collecting material including the step of holding a graduated cylindrical container by a detachable variable angle handle. A kit for a female urinary cup for holding liquid or solid materials comprising a cylindrical container including exterior threads on which a cap may be screwed, a holder attached to a sidewall of the container, a detachable handle optionally coupled to the holder, the handle capable of being adjusted to variable angles when coupled to the holder, and instructions for use of the female urinary cup.

Abstract: Technologies for the sensing of biofeedback signals of a user include a body area network (BAN) system comprising one or more biofeedback sensors and one or more BAN controllers. The biofeedback sensors are configured to sense BAN signals, which may include biofeedback signals and body-coupled communication (BCC) signals. To facilitate communication, the biofeedback sensors may demultiplex the sensed BAN signals into biofeedback signals and incoming BCC signals. Similarly, the biofeedback sensors may multiplex outgoing BCC signals with sensed biofeedback signals. The BAN controller may communicate in a similar manner. Additionally, the BAN controller may process incoming BCC signals and provide feedback to the user based on BCC signals received from the biofeedback sensors.

Abstract: A measuring device comprises: a first housing having at least one measuring electrode; a second housing connected to the first housing and housing a substrate which has at least one terminal and includes a circuit that conducts a measurement process; and at least one connecting member disposed between the first housing and the second housing. The at least one connecting member is formed of a unitary member. One end of the at least one connecting member is connected to the at least one terminal, while the other end of the at least one connecting member is in contact with the at least one measuring electrode due to an elastic force of the at least one connecting member itself.

Abstract: A sampling system for an individual to self-collect sample form mucous tissue is disclosed here. The collecting device has a flexible shaft having a handle at one end, and a sample collecting element removably connectable with the other end of the shaft and operable to collect a cell sample from mucous tissue of an individual. The collecting element includes an RFID tag for tracking the device and the sample once it is collected onto the collecting element. The system includes a sealable unit to store the sample collecting element having a cell sample thereon.

Abstract: According to one aspect of the present disclosure, an electromyography (EMG) circuit comprises a difference circuit, rectification circuit, offset removal circuit, and integration circuit. The difference circuit is configured to create an EMG signal based on a difference between two action potential voltages. Creation of the EMG signal introduces a voltage offset, not already present in the action potential voltages, that centers the EMG signal about a non-zero voltage. The rectification circuit is connected to the difference circuit and is configured to rectify the EMG signal about the non-zero voltage to create a rectified EMG signal. The offset removal circuit is configured to remove the voltage offset from the rectified EMG signal to create an adjusted EMG signal. The integration circuit is connected to the offset removal circuit and is configured to integrate the adjusted EMG signal to produce a first EMG output signal for a client device.

Abstract: A real time visualization method and system for evaluating and monitoring recovery progress of Anterior Cruciate Ligament reconstructed/injured subject is provided. The method includes receiving multiple super-imposed bio-signals from an electromyogram (EMG) for muscles of limbs of the patient and signals pertaining to three dimensional kinematics measurement from a motion sensor set, processing the signals to extract wavelet features and evaluating the wavelet features to determine the extent of rehabilitation and a recovery classification of the patient's limb from ACL injury. The system includes an input interface circuit, a processing module, a comparator module and an output interface circuit for providing an estimate of the extent of rehabilitation the patient's limb from ACL injury.

Abstract: A biopsy device to remove tissue from a patient and place a marker in the patient. The device includes a needle with an opening where tissue enters. The tissue which enters the opening is cut and stored in the device. After the desired number of tissue samples are obtained, a marker is released from the same needle opening. The biopsy sampling and marker release are integrated for one hand operation in a single device.