Abstract: Microemulsion gels a) based on oil in water type, comprising an oil phase, substantially consisting of not easily volatile constituents, and an aqueous phase containing one or more O/W emulsifiers free from ethylene oxide and propylene oxide and possibly one or more additional O/W emulsifiers, an emulsifier content which is lower than 20 wt.

Abstract: The invention relates to a process for the production of gaseous microparticles for ultrasonic diagnosis, whose wall material is built up from polyesters of &agr;-, &bgr;- or &ggr;- hydroxycarboxylic acids, particles that are produced according to this process, as well as their use in medical diagnosis.

Abstract: The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.

Abstract: The present invention provides a method for the treatment of viral-induced tumors in mammals, more specifically, human warts. The method uses &agr;- and &bgr;-santalols, or mixtures or derivatives thereof, to prepare medicaments for the treatment of viral-induced tumors i.e., warts caused by the human papillomavirus (HPV) in humans. The method of the invention comprises the topical administration of &agr;- and &bgr;-santalols, or mixtures or derivatives thereof, in a composition derived therefrom, to the human epidermis, as needed. The present invention is also concerned with a unique antiviral composition useful for topical application. The antiviral composition according to this invention is also effective against other DNA viruses such as the DNA pox virus that causes Molluscum contagiosum and may be effective against other DNA viruses such as AIDS virus and RNA viruses.

Abstract: A method of reducing sebum on the surface of skin is provided. The method includes applying topically to the skin a composition comprising an alcohol, pyridoxine hydrochloride or a salt or derivative thereof, and a zinc salt, wherein the composition is applied to the surface of the skin in an amount sufficient to reduce sebum. A topical composition for reducing sebum on the surface of the skin, comprising an alcohol, pyridoxine hydrochloride or a salt or derivative thereof, and a zinc salt in an amount sufficient to reduce the amount of sebum on the surface of the skin is also described.

Abstract: A method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient. The method comprises contacting an intact mucous membrane with a source of levosimendan, and maintaining said source with said mucous membrane for a sufficient time period to deliver levosimendan to the patient. Transmucosal preparations of levosimendan are also described. Levosimendan is useful in the treatment of heart failure.

Abstract: Novel cosmetic compositions for artificially tanning the skin, comprising at least one self-tanning agent, in particular DHA, and at least one dendrimer.

Abstract: The present invention provides a novel vehicle for the delivery of biologically active agents. The vehicle, Maxcell™, is formulated from a novel combination of natural plant extracts and is comprised of Aloe vera polysaccharide fraction Immuno-10, cAMP, piperine, calcium phosphate and glycyrrhizinic acid.

Abstract: Novel radioactive seeds for brachytherapy and a reproducible method of manufacturing the seeds is described, wherein the seeds contain either Pd-103 or I-125 disposed within a cured resin matrix.

Abstract: A composition having analgesic, antiseptic and skin healing promoting activity, suitable for the treatment of burns, sunburns, scalds, irritation, sores and abrasions which includes, as active ingredients, chlorophyll, cod liver oil, and camphor, preferably together with a natural antiseptic agent chosen from niaouli oil, thyme oil, and mixtures thereof, in a pharmaceutically acceptable vehicle for topical application.

Abstract: Topical gelled compositions comprising an optional drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.

Abstract: A distinctive graft copolymer is made by dissolving an oil-modified polyurethane resin in various vinyl monomers (methyl methacrylate, styrene, etc.). The monomer/oil-modified polyurethane solution is then miniemulsion polymerized to form a latex consisting of submicron particles of polymer with the oil-modified polyurethane grafted onto the polymer backbone. The latex can be applied to a substrate, which on drying forms a polymeric film with good film properties. The latex can be used in a latex paint formulation in place of an acrylate, acetate or styrene-divinyl benzene latex. In this way it is possible to produce water-borne oil-modified polyurethane coatings which combine the properties of an oil-based polyurethane coating with easy application and cleanup. The coating will beneficially lack organic solvent exposure of typical standard oil-modified polyurethane coatings.

Abstract: Water-in-oil emulsions (a) with a content of water and optionally water-soluble substances totalling at least 80% by weight, based on the total weight of the preparations, and with a content of lipids, emulsifiers and lipophilic constituents totalling at most 20% by weight, based in each case on the total weight of the preparations, (b) comprising at least one surface-active substance chosen from the group of alkylmethicone copolyols and/or alkyldimethicone copolyols, (c) comprising one or more lipid components which include the lipid phase of the emulsion, (d) where the weight ratio of (b) to (c) is chosen from the range 0.05 to 0.30, preferably 0.06 to 0.14, (e) if the water content is between 75 and 80% by weight, comprising one or more cationic polymers (f) if the water content is more than 80% by weight, not comprising a cationic polymer.

Abstract: The present invention relates to a skin lightening composition comprising (a) a safe and effective amount of a compound of formula (I): wherein Z is Oxygen or Sulfur, (b) an average polarity solvent, (c) a polyhydric alcohol, (d) a solid fatty alcohol, (e) a nonionic surfactant, (f) water, and (g) lecithin wherein at least a portion of the above components (a), (b), (c), (d), (e), (f) and (g) forms a liquid crystal.

Abstract: The invention relates to a cosmetic or pharmaceutical clear water-in-oil emulsion, comprising a water droplet phase dispersed in an oil phase, the average droplet size being no greater than about 1&mgr;, the refractive indices of the oil and water phases being matched to within 3 parts in 10,000.

Abstract: The present invention relates to nanocapsules consisting of a lipid core forming or containing a lipophilic active principle, and of a water-insoluble continuous envelope comprising at least one dendritic polymer of polyester type containing optionally modified terminal hydroxyl functions, and to cosmetic and/or dermatological compositions containing the said nanocapsules based on dendritic polymers.

Abstract: A distinctive graft copolymer is made by dissolving an unsaturated polyester resin in various vinyl monomers (methyl methacrylate, styrene, etc.). The monomer/unsaturated polyester solution is then miniemulsion polymerized to form a latex consisting of submicron particles of polymer with the polyester grafted onto the polymer backbone. The latex can be applied to a substrate, which on drying forms a polymeric film with good film properties. The latex can be used in a latex paint formulation in place of an acrylate, acetate or styrene-divinyl benzene latex. In this way it is possible to produce water-borne unsaturated polyester coatings which combine the film hardness properties of an unsaturated polyester coating with easy application and cleanup. The coating will beneficially lack organic solvent exposure of typical polyester coatings.

Abstract: A nonradioactive glass in particulate form adapted for radiation therapy in a mammal comprise a biodegradable rare earth-lithium borate glass material of a specified composition which, upon being subjected to an effective amount of neutron irradiation, will produce a beta or gamma emitting radioisotope, the radioisotope being distributed throughout the glass material, the glass upon being introduced into a body fluid for radiation therapy being adapted to react therewith causing the radioisotope to form an insoluble compound on the surface of the glass material which is retained in the glass material and thereby prevented from escaping from the treatment site. Radioactive glasses and methods for carrying out radiation therapy with such radioactive glasses are also disclosed.

Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth.

Abstract: The invention relates to a application system for coating, in particular, for making up, keratin fibers, having a reservoir containing a composition for coating, in particular, for making up keratin fibers, in particular, the eyelashes, a removable closure means designed to close the reservoir and an applicator member for applying the composition to the fibers, wherein the coating composition has an aqueous medium and a film-forming polyurethane in the form of solid particles dispersed in the aqueous medium, the composition having a viscosity, measured at 25° C., at a shear rate of 200 s−1, ranging from 5 Pa·s to 18 Pa·s, and wherein the composition is free of wax.