Abstract: The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.

Abstract: An intramedullary stem prosthesis includes a trunnion tapered in a first direction toward a proximal end of the intramedullary stem, and a conical shaft interfacing with the trunnion at a modular taper junction. The conical shaft is tapered in a second direction toward a distal end of the second component and has a proximal portion, a distal portion, and flutes positioned about a longitudinal axis of the conical shaft and extending along an entire length of the conical shaft and terminating at the modular taper junction such that the flutes intersect the modular taper junction. The proximal portion defines a first taper angle, the distal portion defines a second taper angle greater than the first taper angle, and the flutes define a major diameter of the conical shaft. The major diameter tapers at a major diameter taper angle that is constant along the entire length of the conical shaft.

Abstract: There is provided herein a bone anchored implant that is used to support a nasal prosthesis in patients with a missing external nose. The implant consists of central section (which is preferably generally triangular) suspended within the aperture of the nasal cavity by four fixation arms which extend radially to engage the surrounding maxillary bone. The triangular portion may support three fixation points, one at each corner of the triangular portion, which in turn, directly engage the nasal prosthesis either via magnets or mechanical locking interface. Extending radially from the triangular section, the four fixation arms may flatten to a clover leaf arrangement of three apertures which accommodate micro-screws that secure the implant to the surrounding maxillary bone.

Abstract: A new medical apparatus for deployment within an anatomical blood vessel and methods of use thereof. The apparatus comprising: a first tubular wall; and a second tubular wall, placed within the first tubular wall; wherein the first and second tubular walls are firmly connected at their edges, therefore restricted to have same overall longitudinal length; and wherein the second tubular wall is configured to be partially constricted towards its inner radial axis, while maintaining its overall longitudinal length.

Abstract: The invention relates to a prosthesis for implantation into a living body in the form of a magnetic artificial joint, in particular an artificial shoulder joint, comprising: a) a first prosthesis member comprising a socket member, b) a second prosthesis member comprising a head member, c) one of the socket member and the head member is at least partially composed as a permanent magnet and the other one of the socket member and the head member is at least partially composed of a magnetic material, or the socket member and the head member are both at least partially composed as a permanent magnet, d) the socket member comprises a recess on a surface side to be coupled with the head member, the recess comprising a concavely contoured contact surface, e) the head member comprises a projection on a surface side to be coupled with the socket member, the projection comprising a convexly contoured contact surface, f) the convexly contoured contact surface is adapted to the concavely contoured contact surface, such th

Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: Endovascular stent grafts in accordance with various embodiments include one or more channels on a main body graft, the one or more channels defining a passageway for receiving one or more branch portions for treating branch vessels. In various embodiments, the one or more channels on the main body graft may be abluminal, adluminal, or weaved, with respect to a stent structure of the main body graft.

Abstract: An endoluminal device includes a composite yarn with a polymer yarn and an alloy wire. The polymer yarn includes a biodegradable polymer, and the alloy wire includes a biocompatible alloy. An endoluminal device can include a plurality of polymer yarns and at least one alloy wire, in which the polymer yarns include a biodegradable polymer, and the least one alloy wire includes a biocompatible alloy. A surgical system or kit includes an endoluminal device and a delivery instrument.

Abstract: Patient-specific craniofacial implants structured for filling bone voids or planned bone voids in the cranium and face as well as for simultaneously providing soft tissue reconstruction and/or augmentation for improved aesthetic symmetry and appearance of face and skull. Pterional or temporal voids or defects generally result from a chronic skull or lateral facial deformity along with a compromised temporalis muscle or soft tissue distortion from previous surgery. When muscle and fat atrophy occurs in the pterion or temporal face, temporal hollowing deformity generally results where there would be soft tissue but for the atrophy. The patient-specific craniofacial implants with dual-purpose herein are configured to have an augmented region adjacent the temporal region of the face and cranium in order to prevent and/or correct any such temporal hollowing deformity and to utilize this newfound space to strategically embed implantable neurotechnologies for improved outcomes.

Abstract: Provided herein is a system including, in some embodiments, a stent and a catheter. The stent includes a number of filaments arranged to form a tubular body of the stent, a number of microcells forming each filament of the number of filaments, and a port in an end portion of the stent. Each microcell includes a moveable microsurface. The port of the stent may be configured to accept power and control signals for moving the microsurfaces. The catheter may include a cable configured to connect with the port of the stent and provide the power and the control signals for moving the microsurfaces. Moving the microsurfaces may include matching a shape of an anatomical vessel to maintain patency thereof while mitigating stress on the anatomical vessel.

Abstract: An endovascular apparatus takes the form of an expandable tubular body having a retriever, which may include a pair of interconnected hooks. The retriever may be formed from a single piece of material forming the tubular body, and in the case of a pair of hooks thus has a thickness corresponding to approximately twice the wall thickness of the tubular body. The innermost radial portion of the hooks may be offset from a central axis of a lumen formed by the tubular body, which facilitates free insertion of a balloon or the like for purposes of expanding the tubular body. Related methods of manufacturing an endovascular apparatus with a retriever are also described herein.

Abstract: A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.

Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.

Abstract: A device for evacuating a surgical site of a patient includes a container that defines a first end having a tapered surgical site engaging surface and a second end having a pressure source engaging surface. The first end defines a tapered cross-section configured for being engageably received within an opening at the surgical site. In operation, vacuum pressure is applied to the second end in order to create a vacuum within the container to evacuate fluids from the surgical site.

Abstract: Various embodiments of anchors are configured to be inserted into a heart wall of a patient to anchor a suture as an artificial chordae under an appropriate tension for proper valve function. Each of the disclosed anchor embodiments “toggles” from a first position for delivery of the anchor to the heart wall and a second position for insertion of the anchor into the heart wall. In some embodiments, it is the “toggle” to the second position that provides the insertion force for inserting the anchor into the heart muscle sufficient to retain the anchor from accidental withdrawal from the heart wall during normal valve operation (e.g., when a valve leaflet pulls on the suture attached to the anchor during systole). Such anchors are particularly suitable for use in intravascular, transcatheter procedures as described above given the inherent difficulties in providing sufficient force for insertion of an anchor into the heart wall with a flexible catheter.

Abstract: An absorbable stent includes an absorbable matrix. The matrix includes a number of wave-shaped rings connected by connection units and arranged in an axial direction. The wave-shaped ring includes a number of waves arranged in a circumferential direction. A peak, a valley and a support connecting the peak and the valley form the wave. Two adjacent wave-shaped rings and the connection unit form a closed side supporting unit. The matrix has a volume of [4, 40] ?m per unit blood vessel area. The absorbable stent has sufficient radial supporting strength for clinical applications. Moreover, the volume of the matrix per unit blood vessel area is less than volumes of existing stents. When the absorbable stent and existing stents are made of the same material, the absorbable stent has a shorter degradation and absorption cycle.

Abstract: Nasal implants are provided that have a planar type profile with open spaces through portions of the planar type profile. The nasal implant can be compressible along one or more dimensions of the nasal implant, such as the width and length of the planar type profile. Delivery tools for deploying the nasal implants within the nasal tissue are also provided. Methods for deploying the nasal implants within the nasal tissue of the patient are also provided.

Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).

Abstract: A smart screw according to an embodiment may comprise: a screw main body which penetrates an artificial joint including a shell disposed on a hip joint of an object and a liner disposed on the inner surface of the shell and is then inserted into the hip joint; a transducer including a coupling layer that senses a sound wave signal reflected from the liner, a piezo-electric layer formed to determine a frequency of the sound wave signal, and a sound absorbing layer for absorbing the sound wave signal; and a processing module for generating a sound wave signal toward the liner and receiving the sound wave signal sensed by the coupling layer, measuring the thickness of the liner on the basis of the received sound wave signal, and transferring data about the measured thickness of the liner to the outside.