Abstract: Embodiments disclosed herein are directed to intraocular lens devices, systems, and methods that include determining relative tilt and/or vergence rotation of a subject's eyes and focusing one or more intraocular lenses based on the determined vergence rotation.

Abstract: A stent-graft suitable for chimney grafting comprising a sheath and a tubular framework defining a lumen. The stent-graft comprises, at one end of the sheath, at least one bucket formed at the end so as to form a depression in the sheath able to mate with a collateral stent. The stent-graft is applicable to the treatment of vascular pathologies, in particular to treat aneurysms. More particularly, the stent-graft is an endoprosthesis designed to be placed in parallel with at least one other endoprosthesis.

Abstract: An acetabular hip implant and method includes an acetabular shell component having a first feature and a first insert having a second feature that cooperates with the first feature of the acetabular shell component and further includes a third feature. The implant further includes a second insert having a fourth feature that cooperates with the third feature of the first insert and further includes a fifth feature. A femoral head component includes a sixth feature that cooperates with the fifth feature. Interaction between the first and second features, between the third and fourth features, and between the fifth and sixth features mechanically constrains the acetabular hip implant to prevent dislocation of the femoral head during rotation.

Abstract: Embodiments disclosed herein are directed to intraocular lens devices, systems, and methods that include determining relative tilt and/or vergence rotation of a subject's eyes and focusing one or more intraocular lenses based on the determined vergence rotation.

Abstract: Apparatus and method are described including identifying a subject as suffering from a condition that causes the subject to have elevated central venous pressure. In response thereto, a device is placed inside the subject's vena cava such that an upstream end of the device is placed at a location upstream of junctions of the vena cava with all of the subject's renal veins. The device defines a passage through the device, at least a portion of the passage converging in a direction from an upstream end of the device to downstream end of the device. Other applications are also described.

Abstract: An implant system may include a delivery sheath having an actuator mechanism, an anchoring assistance device including an expandable scaffold including a mid-body section, a cusp interface section, and a crown end arrangement, and a replacement heart valve implant. The cusp interface section includes a plurality of loop portions arranged at radial intervals about the expandable scaffold. Each loop portion is circumferentially spaced apart from another loop portion by a region having a deployment ring, the region being configured to span a commissure of the aortic valve and extending distally a shorter distance from the distal end than the loop portions. An elongate deployment member is configured to releasably engage with the deployment rings to actuate the expandable scaffold from a delivery configuration to a deployed configuration. The replacement heart valve implant is configured to be at least partially disposed within the expandable scaffold in the deployed configuration.

Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).

Abstract: A tendon repair implant for treatment of a complete or partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.

Abstract: Adjustable modular spacer device for the articulation of the knee including a tibial component, suitable for being fixedly connected to one end of the tibial bone near to the articulation of the knee, a femoral component, suitable for being fixedly connected to one end of the femoral bone near to the articulation of the knee and suitable for coming into contact and for being articulated with the tibial component, in which the femoral component includes at least one condylar articular portion and an intercondylar central body, in which the intercondylar central body and the at least one condylar articular portion are separate and discrete components of the femoral component.

Abstract: Disclosed herein are flexible prosthetic components that are designed to be snap-fit to bone of a patient. The prosthetic components each have an outer articular surface and an inner bone contacting surface opposing the outer articular surface. The bone contacting surface has an anterior surface and an opposing posterior surface configured to contact corresponding anterior and posterior surfaces of the patient's bone. At least one of the anterior and posterior surfaces includes one or more protrusions extending outwardly therefrom. The anterior and posterior surfaces of the prosthetic components may flex toward and away from one another such that the one or more protrusions may snap-fit into corresponding recesses in the bone. The bone of the patient may be resected to include planar surfaces or resurfaced to include a curved surface corresponding to the respective bone contacting surface of the prosthetic components.

Abstract: A glenoid trial and implant assembly for use in reverse total shoulder arthroplasty is provided along with a method for using the same. The glenoid trial and implant assembly includes a baseplate assembly, an adapter assembly, a glenoid trial, a glenoid implant, a humeral cup, and a positioning guide. The glenoid trial is coupled to the adapter assembly when the glenoid trial and implant assembly is assembled in a trialing configuration. The glenoid implant is coupled to the adapter assembly when the glenoid trial and implant assembly is assembled in an installed configuration. A temporary connection, which may be magnetic, releasably couples the glenoid trial to the adapter assembly and provides separation of the glenoid trial and the adapter assembly without requiring disassembly of the adapter assembly. A permanent connection fixes the glenoid implant to the adapter assembly.

Abstract: A method and device for anchoring a prosthetic heart valve or annuloplasty ring to a valve annulus in a heart and a method of implanting same is disclosed. The device can include a prosthetic valve or annuloplasty ring with one or more anchors configured to be threaded or otherwise passed underneath a native leaflet and/or subvalvular tissue to secure the device at the native annulus.

Abstract: A humeral cut guide member for resectioning or resurfacing a humeral head, including a bone-engagement member including a first patient-specific bone-engagement surface that is complementary and made to substantially mate and nest in only one position on a specific patient's humeral head; a registration member connected to the bone-engagement member including a second patient-specific bone engagement surface that is sized and made to substantially mate and nest in only one position with the specific patient's bicipital groove; and a cut guide plate connected to the bone-engagement member and defining an elongated slot.

Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

Abstract: Embodiments hereof relate to a transcatheter valve prosthesis including a tubular fabric body, a first or inflow tubular scaffold attached to a first end portion of the tubular fabric body, and a second or outflow tubular scaffold attached to a second end portion of the tubular fabric body. A prosthetic valve component is disposed within and secured to an intermediate portion of the tubular fabric body that longitudinally extends between the first and second end portions of the tubular fabric body. The intermediate portion is unsupported such that neither of the first and second tubular scaffolds surrounds the intermediate portion of the tubular fabric body. The intermediate portion may include one or more windows for coronary access and may include one or more commissure reinforcement members coupled thereto to provide support for the prosthetic valve component.

Abstract: An endovascular prosthesis and method of constructing a prosthesis device for implantation into the lumen of a body vessel. The endovascular prosthesis includes a fenestration in the device surrounded by an inner edge, and the inner edge further surrounded by an outer edge of larger diameter. A shaped protrusion of semi-rigid graft material spans the distance between the inner edge and the outer edge connecting the two edges. The shape protrusion has a surface area larger than the plane of the tubular body between the edges and therefore will have excess material. This excess material allows the inner edge and the fenestration to move within the circumference of the outer edge. The shaped protrusion may also form a semi-rigid dome.

Abstract: Heart valve prosthesis are disclosed that include a frame or support structure having an inflow portion, a valve-retaining tubular or central portion and a pair of support arms. The inflow portion radially extends from a first end of the valve-retaining tubular portion and the pair of support arms are circumferentially spaced apart and radially extend from an opposing second end of the valve-retaining tubular portion.

Abstract: A stent covering includes a polymeric tube having a first end, a second end and a length extending therebetween, the polymeric tube including an inner surface defining a lumen and an outer surface. A plurality of tissue ingrowth features are formed on the outer surface of the polymeric tube, at least some of the plurality of tissue ingrowth features including polymeric loops that extend above the outer surface such that, once implanted, tissue can grow between the outer surface and the polymeric loops. A stent may include such a stent covering.

Abstract: A medical device for holding a cardiac valve implant includes an elongate support defining a peripheral edge with a curvature about which the cardiac valve implant can be fitted. The elongate support includes a resilient portion for resiliently holding the cardiac valve implant in place in the device, and a support tool for holding a cardiac valve implant comprising first and second elongate support members being separate and radially movable in relation to each other, each having a curvature about which the cardiac valve implant can be fitted and a manipulator portion connected to the first and second elongate support members.

Abstract: Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.