Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

Abstract: A fluid injection system includes: a first apparatus which is attached to a human body and injects a fluid into the human body; and a second apparatus which is attached to a wrist of the human body and remotely controls the first apparatus, wherein the second apparatus includes an entry section accepting an entry of an operation command to the first apparatus and a first communicating section transmitting the operation command to the first apparatus, and the first apparatus includes a second communicating section receiving the operation command, a storing section storing the fluid, and a transporting section transporting the fluid from the storing section and injecting the fluid into the human body based on the operation command.

Abstract: A medium- and high-pressure pulsed jet generator (1) for injecting controlled volumes of at least one medical liquid (7) includes a high-pressure chamber (2) and at least one connector (24) for at least one flexible pouch containing the medical liquid. The flexible pouch/es (6) is/are connected, via a connection tube, to a hydraulic sequencer (28) which is mounted in the high-pressure chamber, is exposed to the pressure inside the chamber (2), sequences the liquid discharged from the flexible pouch into a pulsed jet (11), is composed of a hydraulic connection (20) that is designed as or includes a deformable flexible sleeve (29) hydraulically communicating with the pouch/es (6) at the inlet and with a hand-held intervention element (40) or a catheter at the outlet, and includes hydraulic stops (31, 32) that are disposed on both sides of the flexible deformable sleeve (29) and are operated using a control element (33).

Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

Abstract: An enteral feeding device comprises a connector with a tube for establishing a fluid connection between the connector and a button; the enteral feeding device incorporating a button with an aperture; the connector's tube incorporating an ear projecting laterally from the tube; the button's aperture being substantially circular with a recessed portion sized and shaped to allow the connector's ear to be inserted into the button; wherein the button's aperture further incorporates at least one inwardly projecting ear; and the connector's tube incorporates at least one recessed channel for receiving the at least one ear during the connection of the tube to the button.

Abstract: A device for introduction into a body vessel includes a main elongated element, a balloon positioned at the main elongated element distal end, a distal connecting element positioned at the distal end of the balloon to receive a guidewire during use, and a longitudinally movable sheath positioned external to the main elongated element, a position of the sheath distal end with respect to the balloon defining an exposed portion of the balloon that expands when fluid is delivered to the balloon through the inflation lumen.

Abstract: A catheter includes a first opening portion positioned at a distal end; a first curved portion positioned proximally of the first opening portion, and is curved in a first direction; a second curved portion positioned proximally of the first curved portion, and is curved in a second direction; an intermediate portion provided between the first curved portion and the second curved portion; and a second opening portion formed in the intermediate portion. In a transverse sectional view of the intermediate portion, the first direction and the second direction are directions directed towards a first side of the intermediate portion. In addition, in the transverse sectional view of the intermediate portion, the second opening portion opens in a third direction directed towards a second side of the intermediate portion that is opposite to the first side.

Abstract: The present invention is an alternate IV line clasp for holding IV equipment securely to a patient's body without the use of tape. The clasp has a contoured recessed channel provided in an underside of a head of the clasp such that the channel receives and holds the IV equipment therein. The clasp has an adjustable, slightly elastic strap that extends over the head of the clasp by inserting through slits provided on either side of the head and then extending around the patient's body in the area of the body where the IV is installed. The two ends of the strap are provided, respectively, with hook and loop fasteners that allow the strap to be removably secured to itself and around the patient's body to hold the head and attached IV in place.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A method for monitoring the status of an implanted catheter includes monitoring changes in pressure within a lumen of a catheter associated with physiological parameters (“physiological pressure”) and changes in pressure within the lumen of the catheter associated with bolus infusion of fluid into the catheter or bolus withdrawal of infusion from the catheter (“bolus pressure”). Methods that employ monitoring both physiological pressure and bolus pressure can provide information that cannot be obtained from monitoring physiological pressure or bolus pressure alone.

Abstract: Fluid delivery devices and methods for delivering fluid to the body of the patient are disclosed which include a housing having an upper wall and a lower wall defining an opening, a well-arrangement mechanism configured to be disposed inside the housing and between the upper wall and the lower wall and including a tubular member having a bore, wherein the bore is configured to be disposed within the opening, a penetrating cartridge for delivery of therapeutic fluid to the body of the patient, wherein the penetrating cartridge is configured to engage the bore following its insertion through the upper opening and the lower opening, and a tilting tool configured to rotate the bore prior to insertion of the penetrating cartridge, wherein therapeutic fluid is configured to be delivered through the tubular member into the penetrating cartridge into the body of the patient when the penetrating cartridge engages the bore.

Abstract: A breastshield unit for expressing human breastmilk has a receiving part for receiving a human nipple, an underpressure chamber for applying an under-pressure to the nipple, wherein the receiving part opens into this underpressure chamber, and a membrane for generating an underpressure in the underpressure chamber. The membrane is designed in one or more pieces and at least partially surrounds the receiving part. This breastshield unit permits a separation of media in the area near the breast. It is small and easy to clean and is suitable in particular for use as a hands-free breastshield unit.

Abstract: A syringe with a syringe cylinder has a Luer-lock connection arranged at an axial end of the syringe cylinder. The Luer-lock connection includes a Luer cone and a rotatable threaded sleeve surrounding this. The rotatable threaded sleeve of the Luer-lock connection includes a radially outwardly directed prominence.

Abstract: A needle safety shield 10 for use with a syringe 10 having a barrel 14, a needle and a plunger rod 16. The safety shield 10 has a first tube 22. A second tube 26 is arranged for sliding movement within the first tube 22. A pin 46 is connected to one of the first and second tubes 22, 26. An activation ring 32 has a stop 72. A drive spring 34 biases the activation ring 32 in a proximal direction to place the stop 72 in engagement with the pin 46 to retain the first and second tubes 22, 26 in a retracted configuration. The movement of the plunger rod 16 to engage the activation ring 32 compresses the drive spring 34, moving the activation ring 32 distally, and moving the stop 72 out of engagement with the pin 46, allowing the drive spring 34 to move the first and second tubes 22, 26 into an extended configuration.

Abstract: A flexible container for storing a liquid medicament and a device for the automated release of the liquid medicament from the flexible container are disclosed. The flexible container includes a wall and an access opening. The wall of the flexible container comprises two sheets of flexible material sealed together such that a storage volume intended to contain the liquid medicament is defined. The access opening provides a fluid connection to a conduit system in fluid connection with the storage volume via a fluid channel arranged between the storage volume and the access opening, wherein the fluid channel is formed by a cavity arranged on at least one of the two sheets.

Abstract: A nebulizer includes a main body that has a nebulizer outlet and an air channel in communication with the nebulizer outlet. The main body supports a medicine reservoir and a mesh that engages the medicine reservoir and air channel and vibrates to atomize medicine from the medicine reservoir into the air channel for discharge through the nebulizer outlet. The nebulizer outlet and mesh are configured to be received within the oral cavity of the patient when the nebulizer is in use.

Abstract: An injection device comprises a syringe extendible against a spring bias from a retracted position in a housing to a projecting injecting position. A spring biased plunger has collapsible elbows which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung.

Abstract: A pre-slit cannula diaphragm is integrated into a peripheral venous catheter to provide a cannula ready intravenous catheter with a cannula chamber closed to the environment, thereby reducing the risk to health-care providers from blood borne diseases and the risk to patients from airborne hazards. The cannula ready intravenous catheter includes a cylindrical housing that provides an uninterrupted smooth surface, for reducing skin irritation. A proximal end of the cylindrical housing provides a luer-type connector site, and a distal end of the cylindrical housing provides a catheter hub. The catheter hub supports a catheter tube, which extends from a distal end of the catheter hub.