Abstract: Microcapsules encapsulating oily core materials have a shell material of hybrid polyurea and poly(beta-amino esters) (PU/PBAE). The microcapsules may have a single shell of hybrid PU/PBAE, dual shells including hybrid PU/PBAE in an inner shell and PBAE in an outer shell crosslinked and deposited to the inner shell, or multiple shells including PU in an inner shell, hybrid PU/PBAE in a transitioning shell, and PBAE in an outer shell. Formation of the microcapsules includes polymerization between multifunctional amine and multifunctional acrylate to produce a water soluble PBAE; polymerization between polyisocyanate in oil phase and multifunctional amine in aqueous solution to produce PU microcapsule, polymerization between polyisocyanate and the amine moiety of PBAE prepolymer to produce hybrid PU/PBAE microcapsule wall; and polymerization between multifunctional acrylate and primary or secondary amine moiety of the PBAE prepolymer to form a PBAE outer shell.

Abstract: A 6?-(3-chlorophenyl)-2?-ethoxy-3,4?-bipyridine-3?-carbonitrile compound, its synthesis, and its use as an antimicrobial agent.

Abstract: Provided herein are formulations and compositions for ocular diseases or disorders such as dry eye disease. Further provided herein are methods for manufacturing ocular formulations and compositions.

Abstract: Compositions of foods, vitamin and mineral supplements, topical or oral drugs, and cosmetic products containing a small peptide or peptides for slowing degradation, for example by transition metals. The peptides are di, tri, terra-, and/or penta-peptides containing two or more aspartic acid residues. The degradation of several of the vitamin and other constituents vitamin-mineral supplements can be considerably slowed by composition incorporating such peptides, particularly if soluble (and thus bioavailable) forms of copper and/or iron are also present. The peptides can be hydrolyzed by the normal digestive process thus releasing bound metals. Multiple aspartate peptide(s) compositions with foods, topical or oral drugs, cosmetic, and hair care products can replace synthetic chelating preservative agents. Methods are also described to effectively slow degradation and preserve the above products using multiple aspartate peptides.

Abstract: An ultrasound-induced drug delivery system is described, using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule, and a method for preparing the drug delivery system, by generating the nanobubbles in an oil into which the drug is dissolved using a nanobubble generator, and then microencapsulating them. The drug delivery system has an effect of maximizing a drug delivery efficiency as the nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system. Since the drug delivery system contains a plurality of nanobubbles within the microcapsules, it can also be used as a contrast agent, or can be used to simultaneously perform in vivo diagnosis and treatment.

Abstract: A method is disclosed for preparing a composition including controlled release particles includes: (a) preparing an oil phase including at least one hydrophobic active ingredient, at least one isocyanate, at least one epoxy, at least one organofunctional silane, optionally at least one pre-reacted natural material resin, and optionally a plasticizer; (b) preparing an aqueous phase comprising an emulsifier; (c) combining the oil phase and the aqueous phase to provide an aqueous suspension; (d) adding at least one amine moiety containing material to provide a barrier; (e) heating; (f) adding a natural material to provide a microcapsule having hydroxyl moieties or amine moieties on a surface thereof; (g) adding an aldehyde to react with the surface moieties; and (h) adding structuring agents to provide the controlled release particles homogeneously suspended in an aqueous dispersion. The composition is also disclosed.

Abstract: The purpose of the present invention is to provide an ointment preparation in which both separation over time and discoloration over time are suppressed. Both separation over time and discoloration over time are suppressed in: a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder and a specific (C) additive, and (D) a solvent; and a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder, and (D) a solvent.

Abstract: The present disclosure provides a pyraclostrobin microcapsule based on sodium alginate, which is prepared by mixing pyraclostrobin original drug dissolved in ethyl acetate, 1% aqueous sodium alginate solution, and 5% aqueous calcium carbonate solution at 25° C., and mixing the mixed solution with liquid paraffin containing 10% emulsifier A-110, maintaining a shear rate of 1000 r/min to emulsify for 10 min; using 87.5 mmol/L glacial acetic acid to reduce the pH of the mixed phase, such that the cross-linking reaction between ions can be formed into microcapsules; finally using pH 4.5 acetate buffer to wash and separate the microcapsule slurry, and then centrifuging and freeze-drying to prepare the pyraclostrobin SA microcapsules. The microcapsules prepared by the present disclosure have excellent formulation performance and can be used for the control of Fusarium pseudograminearum.

Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.

Abstract: Compositions for topical treatment to reduce the appearance of the hyperpigmented lesions of melasma are presented. Such compositions include defensins in concentrations that are below those that exhibit antimicrobial activity, and can be in the form of a topically applied gel, lotion, wash, shampoo, cream, or mask. Various formulations for such compositions, which can include various pharmaceutically acceptable stabilizers, emollients, and fragrances, are provided.

Abstract: Disclosed is a composition including controlled release particles, wherein each of the controlled release particles includes: (a) a core including at least one hydrophobic active ingredient; and (b) a wall at least partially surrounding the core and including: (i) an outer layer including a polyurea; (ii) an intermediate layer under the outer layer and including a carbamic-carboxylic anhydride; (iii) an inner layer under the intermediate layer and including an acrylate copolymer; and optionally (iv) an optional outer layer above the outer layer and including a quaternary amine containing moiety, wherein the viscosity of the core can be manipulated from a low viscosity liquid to a semisolid. A method for preparing the composition is also disclosed.

Abstract: The present disclosure relates to sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises N-oxide of active pharmaceutical agent at a level less than 1 wt %, based on weight of the composition. In some case, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

Abstract: The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

Abstract: Described herein is a process for producing perfume- or flavor-containing microcapsules with improved deposition of encapsulated actives on targeted surfaces such as fiber, hair and skin, which can be used in home or personal care products. Also described herein are microcapsules obtainable by such a process and consumer products including these microcapsules.

Abstract: The present invention describes the use of a NK1-antagonist, in constant combination with pyridostigmine, to facilitate the treatment of a patient suffering from myasthenia gravis by providing a therapeutically effective pyridostigmine bromide daily dose without the dose-limiting gastro-intestinal adverse effects.

Abstract: Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.

Abstract: The invention relates to a chewing gum comprising at least a gum core comprising nicotine polacrilex, at least a one outer coating covering the core, comprising at least one sugar alcohol or mixtures of sugar alcohols and, at least a one portion fused onto the outer coating, wherein the portion comprises nicotine bitartrate or nicotine ditartrate dihydrate and at least one sugar alcohol or a mixture of sugar alcohols and at least one buffer present in the coating and/or in a portion fused to the coating.

Abstract: Described herein is a new process for the preparation of polysuccinimide derivatives-based core-shell microcapsules. Also described are microcapsules, as well as perfuming compositions and consumer products including these microcapsules, in particular perfumed consumer products in the form of home care or personal care products.

Abstract: An object is to provide a foamable aerosol composition that can be continuously ejected from the container to form dense and uniform foam, and that the formed foam has certain elasticity as well as can be easily spread on an object, and the foamable aerosol composition comprises a stock solution including cellulose nanofibers and a propellant is provided.

Abstract: Disclosed is a composition comprising at least one core-shell microcapsule in a suspending medium. The microcapsule comprises a core and a shell around said core. The shell comprises a hyperbranched polysaccharide selected from the group consisting of amylopectins, dextrins, hyperbranched starches, glycogen and phytoglycogen and mixtures thereof.