Patents Examined by Doan T Phan
  • Patent number: 11912785
    Abstract: Compositions of foods, vitamin and mineral supplements, topical or oral drugs, and cosmetic products containing a small peptide or peptides for slowing degradation, for example by transition metals. The peptides are di, tri, terra-, and/or penta-peptides containing two or more aspartic acid residues. The degradation of several of the vitamin and other constituents vitamin-mineral supplements can be considerably slowed by composition incorporating such peptides, particularly if soluble (and thus bioavailable) forms of copper and/or iron are also present. The peptides can be hydrolyzed by the normal digestive process thus releasing bound metals. Multiple aspartate peptide(s) compositions with foods, topical or oral drugs, cosmetic, and hair care products can replace synthetic chelating preservative agents. Methods are also described to effectively slow degradation and preserve the above products using multiple aspartate peptides.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: February 27, 2024
    Inventors: Steven W. Bailey, June E. Ayling
  • Patent number: 11890370
    Abstract: An ultrasound-induced drug delivery system is described, using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule, and a method for preparing the drug delivery system, by generating the nanobubbles in an oil into which the drug is dissolved using a nanobubble generator, and then microencapsulating them. The drug delivery system has an effect of maximizing a drug delivery efficiency as the nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system. Since the drug delivery system contains a plurality of nanobubbles within the microcapsules, it can also be used as a contrast agent, or can be used to simultaneously perform in vivo diagnosis and treatment.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: February 6, 2024
    Inventor: Myoung Hwan Park
  • Patent number: 11878280
    Abstract: A method is disclosed for preparing a composition including controlled release particles includes: (a) preparing an oil phase including at least one hydrophobic active ingredient, at least one isocyanate, at least one epoxy, at least one organofunctional silane, optionally at least one pre-reacted natural material resin, and optionally a plasticizer; (b) preparing an aqueous phase comprising an emulsifier; (c) combining the oil phase and the aqueous phase to provide an aqueous suspension; (d) adding at least one amine moiety containing material to provide a barrier; (e) heating; (f) adding a natural material to provide a microcapsule having hydroxyl moieties or amine moieties on a surface thereof; (g) adding an aldehyde to react with the surface moieties; and (h) adding structuring agents to provide the controlled release particles homogeneously suspended in an aqueous dispersion. The composition is also disclosed.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: January 23, 2024
    Assignee: TRUCAPSOL LLC
    Inventors: Anil Khanal, Praveen Bachawala, Jiten Dihora
  • Patent number: 11872304
    Abstract: The purpose of the present invention is to provide an ointment preparation in which both separation over time and discoloration over time are suppressed. Both separation over time and discoloration over time are suppressed in: a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder and a specific (C) additive, and (D) a solvent; and a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder, and (D) a solvent.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: January 16, 2024
    Inventors: Masato Shigeyama, Toshiya Nagiri, Yuki Takeuchi, Yu Mima, Katsunori Shirai, Toshimitsu Terao
  • Patent number: 11865506
    Abstract: The present disclosure provides a pyraclostrobin microcapsule based on sodium alginate, which is prepared by mixing pyraclostrobin original drug dissolved in ethyl acetate, 1% aqueous sodium alginate solution, and 5% aqueous calcium carbonate solution at 25° C., and mixing the mixed solution with liquid paraffin containing 10% emulsifier A-110, maintaining a shear rate of 1000 r/min to emulsify for 10 min; using 87.5 mmol/L glacial acetic acid to reduce the pH of the mixed phase, such that the cross-linking reaction between ions can be formed into microcapsules; finally using pH 4.5 acetate buffer to wash and separate the microcapsule slurry, and then centrifuging and freeze-drying to prepare the pyraclostrobin SA microcapsules. The microcapsules prepared by the present disclosure have excellent formulation performance and can be used for the control of Fusarium pseudograminearum.
    Type: Grant
    Filed: April 7, 2023
    Date of Patent: January 9, 2024
    Inventors: Chengqi Zhang, Mengqiu Wang, Yu Chi, Li Chen, Xianyan Su, Xuexiang Ren, Zhenghe Ye
  • Patent number: 11857568
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: January 2, 2024
    Assignee: Advantage Therapeutics, Inc.
    Inventors: Markus Mandler, Achim Schneeberger, Wolfgang Zauner, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Patent number: 11806384
    Abstract: Compositions for topical treatment to reduce the appearance of the hyperpigmented lesions of melasma are presented. Such compositions include defensins in concentrations that are below those that exhibit antimicrobial activity, and can be in the form of a topically applied gel, lotion, wash, shampoo, cream, or mask. Various formulations for such compositions, which can include various pharmaceutically acceptable stabilizers, emollients, and fragrances, are provided.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: November 7, 2023
    Inventor: Nikolay Turovets
  • Patent number: 11794161
    Abstract: Disclosed is a composition including controlled release particles, wherein each of the controlled release particles includes: (a) a core including at least one hydrophobic active ingredient; and (b) a wall at least partially surrounding the core and including: (i) an outer layer including a polyurea; (ii) an intermediate layer under the outer layer and including a carbamic-carboxylic anhydride; (iii) an inner layer under the intermediate layer and including an acrylate copolymer; and optionally (iv) an optional outer layer above the outer layer and including a quaternary amine containing moiety, wherein the viscosity of the core can be manipulated from a low viscosity liquid to a semisolid. A method for preparing the composition is also disclosed.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: October 24, 2023
    Assignee: TRUCAPSOL, LLC
    Inventors: Jiten Dihora, Praveen Bachawala
  • Patent number: 11771624
    Abstract: The present disclosure relates to sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises N-oxide of active pharmaceutical agent at a level less than 1 wt %, based on weight of the composition. In some case, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: October 3, 2023
    Inventors: Andrew R. Miksztal, Judy Joice, Susan Autio, Mark P. Davis
  • Patent number: 11766426
    Abstract: The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: September 26, 2023
    Assignee: Excalibur Pharmaceuticals, Inc.
    Inventors: Juan Socorro Armendáriz Borunda, José Agustín Rogelio Magaña Castro, Pedro Peña Santoyo, Laura Vázquez Cervantes
  • Patent number: 11759759
    Abstract: Described herein is a process for producing perfume- or flavor-containing microcapsules with improved deposition of encapsulated actives on targeted surfaces such as fiber, hair and skin, which can be used in home or personal care products. Also described herein are microcapsules obtainable by such a process and consumer products including these microcapsules.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: September 19, 2023
    Assignee: FIRMENICH SA
    Inventors: Lei Shi, Lahoussine Ouali, Lei Han
  • Patent number: 11752141
    Abstract: The present invention describes the use of a NK1-antagonist, in constant combination with pyridostigmine, to facilitate the treatment of a patient suffering from myasthenia gravis by providing a therapeutically effective pyridostigmine bromide daily dose without the dose-limiting gastro-intestinal adverse effects.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: September 12, 2023
    Assignee: DAS-MG, Inc.
    Inventor: Kathleen Clarence-Smith
  • Patent number: 11717593
    Abstract: Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 8, 2023
    Assignee: Avery Dennison Corporation
    Inventor: Neal Carty
  • Patent number: 11679081
    Abstract: The invention relates to a chewing gum comprising at least a gum core comprising nicotine polacrilex, at least a one outer coating covering the core, comprising at least one sugar alcohol or mixtures of sugar alcohols and, at least a one portion fused onto the outer coating, wherein the portion comprises nicotine bitartrate or nicotine ditartrate dihydrate and at least one sugar alcohol or a mixture of sugar alcohols and at least one buffer present in the coating and/or in a portion fused to the coating.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 20, 2023
    Assignee: McNeil AB
    Inventors: Kristina Thyresson, Gregory Koll, Jill Nilgard, Gerard McNally, Katarina Lindell
  • Patent number: 11666881
    Abstract: Described herein is a new process for the preparation of polysuccinimide derivatives-based core-shell microcapsules. Also described are microcapsules, as well as perfuming compositions and consumer products including these microcapsules, in particular perfumed consumer products in the form of home care or personal care products.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: June 6, 2023
    Assignee: FIRMENICH SA
    Inventors: Nicolas Paret, Damien Berthier
  • Patent number: 11648189
    Abstract: An object is to provide a foamable aerosol composition that can be continuously ejected from the container to form dense and uniform foam, and that the formed foam has certain elasticity as well as can be easily spread on an object, and the foamable aerosol composition comprises a stock solution including cellulose nanofibers and a propellant is provided.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: May 16, 2023
    Inventors: Takafumi Kawasaki, Takeshi Nakatani, Noriko Motoyama
  • Patent number: 11622928
    Abstract: Disclosed is a composition comprising at least one core-shell microcapsule in a suspending medium. The microcapsule comprises a core and a shell around said core. The shell comprises a hyperbranched polysaccharide selected from the group consisting of amylopectins, dextrins, hyperbranched starches, glycogen and phytoglycogen and mixtures thereof.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 11, 2023
    Assignee: GIVAUDAN SA
    Inventors: Nelly Bulgarelli, Ian Michael Harrison
  • Patent number: 11596618
    Abstract: Oral formulations comprising at least one cannabinoid and at least one mouthfeel experience enhancer are described. For example, methods and materials for preparing a dissolvable lozenge comprising a combination of THC and CBD and Szechuan peppercorn or an extract thereof are provided.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: March 7, 2023
    Assignee: Resurgent Biosciences, Inc.
    Inventors: Eric Greenbaum, Emily Leuer, Nikolaus Goran, Justin Bueno
  • Patent number: 11578068
    Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: February 14, 2023
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Alessandro Accetta, Fabio Rancati, Christine Edwards, Elizabeth Anne Skidmore
  • Patent number: 11559485
    Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor nilotinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer. In particular, the present disclosure provides a pharmaceutical composition in the form of an orally disintegrating tablet. In some embodiments, the pharmaceutical compositions can be administered without regard to food consumption. In other embodiments, the pharmaceutical compositions can be administered at a significantly lower dose as compared to a commercially available immediate-release nilotinib formulation, while providing a comparable therapeutic effect.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: January 24, 2023
    Assignee: NANOCOPOEIA, LLC
    Inventors: Christian F. Wertz, Tzehaw Chen, Joseph McTarsney, Sarah M. Rieschl, Limin Shi