Abstract: Is herein described a nanoparticle ophthalmic composition comprising at least 0.1% of Perilla frutescens extract and at least 0.1% of hyaluronic acid or a salt thereof wherein the Perilla frutescens extract has a content of polyphenols of at least 2.5% by weight of the total weight of the extract and to the use of said ophthalmic composition in the treatment of ocular disorders or diseases such as tear dysfunction syndrome, dry eye, diabetic retinopathy and glaucoma, preferably in the treatment of tear dysfunction syndrome.

Abstract: The present invention relates to a composition for treating keratin materials, in particular keratin fibres, and in particular human keratin fibres such as the hair, comprising, in a cosmetically acceptable medium: at least one fatty substance in a content of greater than or equal to 10% by weight relative to the total weight of the composition, at least one oxyalkylenated (OA), preferably oxyethylenated (OE), nonionic surfactant comprising a number of OA units, preferably OE units, ranging from 1 to 9, at least one oxyalkylenated (OA), preferably oxyethylenated (OE), nonionic surfactant comprising at least 10 OA units, preferably OE units, the weight ratio of the amount of oxyalkylenated (OA), preferably oxyethylenated, nonionic surfactant(s) comprising a number of OA units, preferably OE units, ranging from 1 to 9 to the amount of oxyalkylenated (OA), preferably oxyethylenated, nonionic surfactants comprising at least 10 OA units, preferably OE units, being greater than 1, at least one chemical oxidizing ag

Abstract: To provide a medical sheet with which a surface (a portion) subjected to ion bombardment, and a surface (a portion) which has not been subjected to ion bombardment can be distinguished from each other; and a production method therefor. When ?b refers to the difference between value b1, which is the b value of a roughened surface portion 3, and value b2, which is the b value of a second surface 7, this medical sheet has a ?b in the range of 1.5-11 inclusive. A production method for the medical sheet includes: a surface roughening step in which a portion or the entirety of a first surface 5 of a sheet including polytetrafluoroethylene is subjected to surface roughening treatment to form a roughened surface portion 5; and a heating step in which the sheet which includes the polytetrafluoroethylene and which has undergone the surface roughening step is heated to obtain the medical sheet.

Abstract: The present invention provides a composition that has an excellent hardness adjustment action, can be used as a solidifying agent for various cosmetics, and when added to cosmetics, can impart those cosmetics with excellent shape retention properties, an oil oozing suppression effect during use, a favorable texture and good storage stability, and also provides an oily solid cosmetic to which the composition has been added. Specifically, the invention provides a solid wax composition containing a component (A): candelilla wax, and a component (B): a monoester having a total of 40 to 48 carbon atoms, wherein the mass ratio between the component (A) and the component (B) in the solid wax composition satisfies component (A):component (B)=45:55 to 95:5, and the monoester is a monoester of a monovalent fatty acid and a monohydric alcohol.

Abstract: A skin protecting product that includes cyclopentasiloxane, disiloxane, octylacrylamide, acrylates, butylaminoethyl methacrylate copolymer, isopropyl myristate, hydroxypropyl gluconomide, hydroxyproply ammonium gluconate, phenoxyethanol, Cetearyl alcohol, cetyl alcohol, cetyl PPG, PPG-10/1 dimethicone, hydroxyethyl urea, zinc oxide, titanium oxide, fragrance such as perfumes or colognes, vitamin C, and isodecyl neopentanoate. The skin protecting product is applied daily along with sunscreen to help reduce the chance of skin damage related conditions and illnesses that result from sun exposure. The product is applied on hard to reach areas such as the scalp. The product is weightless, so the user is not bothered by the application of the product. The skin protecting product comes in various forms such as a spray, gel or lotion.

Abstract: A skincare composition containing plant extracts and a preparation method thereof. The skincare composition containing plant extracts, comprising, by weight percentage, the following components: 0.2-0.5% of a complex plant extract, 1-3.5% of a carbohydrate derivative, 50-60% of a thickener, 1.5-4% of a first skin conditioner, 0.1-0.3% of a second skin conditioner, 2-3% of a third skin conditioner, 3-5% of a first moisturizer, 4-6% of a second moisturizer, and the balance of deionized water.

Abstract: Methods and uses for controlling non-crop pests (especially of the orders Blattodea, Diptera, Hemiptera, Hymenoptera, Isoptera, Orthoptera) and/or populations of social insects and non-social solitary or gregarious insects, especially ants, wasps, termites and cockroaches, with a carboxamide compound and its mixtures, and compositions comprising it, are disclosed.

Abstract: The present invention relates to the synthesis of new classes of sunscreen agents, the usage of such sunscreen agents in sunscreen formulations aiming at reduction of sunscreen agents' skin penetration, and a formulation technology using existing sunscreen agents aiming at reduction of sunscreen agents' skin penetration, therefore improving the bio-safety of the sunscreen products.

Abstract: Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics.

Abstract: A synergistic preservative composition comprises sorbic acid or a salt thereof, benzyl alcohol, and a mixture of (i) 1,2-propanediol and/or 1,3-propanediol, and (ii), 4-butanediol and/or 1,3-butanediol. The composition is particularly suited for the preservation of cosmetics and personal care products.

Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.

Abstract: The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

Abstract: A drug delivery system is provided in the form of a controlled release, bioerodible pellet for subdermal implantation. The pellet is bioerodible, and provides for the sustained release of a pharmacologically active agent over an extended time period. As such, the drug delivery system finds significant utility in chronic drug administration. Bioerosion products are water soluble, bioresorbed, or both, obviating the need for surgical removal of the implant. Methods for manufacturing and using the drug delivery system are also provided.

Abstract: Methods for creating nanostructured surface features on polymers and polymer composites involve application of low pressure during curing of solid polymer material from a solvent solution. The resulting nanoscale surface features significantly decrease bacterial growth on the surface. Polymer materials having the nanoscale structuring can be used in implantable medical devices to inhibit bacterial growth and infection.

Abstract: A novel lysophospholipid concentrate produced by a process comprising the steps of combining (i) a de-oiled lecithin and (ii) from about 0.5 to about 2% of an enzyme with PLA2 activity. The lysophospholipid concentrate is a pourable, homogenous mixture/solution at or about room temperature with has no significant visible precipitate that (a) has an HLB of greater than 12, (b) contains greater than about 20% lysophosphatidylcholine, and (c) contains greater than about 10% lysophosphatidic acid or an LPA-mimetic. Novel low-urea retinoate compounds produced by the reaction of (a) retinoic acid and (b) one or both of glycerine and/or a monoacylglyceride in the presence of a carbodiimide coupling agent, and preferably in the presence of p-toluene sulfonic acid. The low-urea retinoate is a pourable, homogenous mixture/solution at or about room temperature with no significant visible precipitate.

Abstract: A tympanic construct fabricated from at least one amniotic membrane, at least one chorionic membrane, or at least one amniotic membrane and at least one chorionic membrane obtained from human birth tissue is provided. Methods of preparing a tympanic construct, methods of repairing tympanic membrane defects and surgical sites, as well as kits for the same are also provided.

Abstract: The present invention relates to compositions for fortifying food and/or beverages with iron. More specifically, the present invention relates to compositions comprising Fe(lll), phytic acid, a hydrolysed protein and an acidity regulator, which provide stable and soluble sources of iron for fortifying food and/or beverages.

Abstract: The present invention relates to surfaces which are featured with antimicrobial property. Combinations made with zinc pyrithione, chlorhexidine gluconate and/or triclosan are used in the invention. The invention enables to prevent biodegradation or biocontamination occurring on surfaces. In sectors where surface coating materials are widely used, the pathogen factors (bacteria, yeasts and fungi), which are the causes of surface-borne hygiene, allergy and infectious diseases, are controlled.

Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

Abstract: The invention provides a neural electrode, including a current generation device, a first and a second electrode. The current generation device is connected to the first and second electrodes through a conductive metal wire respectively. At least one of the first and second electrodes is a graphene electrode. The graphene electrode has soft texture and desirable stability to tolerate the repeated pressing and folding treatment, very high charge injection efficiency, and desirable in vivo stability, and is configured to electrically stimulate tissues and organs such as hearts and nerves to promote electrical stimulation and repair of neurons, to further promote regeneration of neural functions. The invention further provides use of a mineralized three-dimensional porous graphene foam material to prepare a bone defect filler. The bone defect filler has desirable biological compatibility, promotes cell proliferation, and accelerates and induces osteogenic differentiation of bone marrow mesenchymal stem cells.