Patents Examined by Donald W. Griffin
  • Patent number: 5242796
    Abstract: A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Functions of the emitted energy are obtained which vary over the wavelengths of the closely spaced spectra in different senses and the functions ratioed, whereby the ratio is indicative of the identity of the DNA fragments.The emitting portion of the reporter-labeled DNA fragment is preferably one of a family of fluorescent dyes based on 9-carboxyethyl-6-hydroxy-3-oxo-3 H-xanthene. These xanthene dyes are covalently attached to the DNA fragments through the carboxylic acid functionality, preferably via an amide linkage. The dyes may be protected by including an alkoxy group at the 9-position. A spacer may be inserted between the dye and the amine.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: September 7, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: James M. Prober, Rudy J. Dam, Charles W. Robertson, Jr, Frank W. Hobbs, Jr., George L. Trainor
  • Patent number: 5045532
    Abstract: A pharmaceutical composition is provided comprising inner ester ganglioside derivatives useful for its peripheral analgesic-antiinflammatory activity in treating pain caused by pathologies of the peripheral nervous system and which can advantageously be administered orally.
    Type: Grant
    Filed: October 20, 1988
    Date of Patent: September 3, 1991
    Assignee: Fidia, S.p.A.
    Inventors: Francesco della Valle, Aurelio Romeo