Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
September 28, 2021
Assignee:
Genentech, Inc.
Inventors:
Justin Scheer, Wenjun Ouyang, Eric Gary Stefanich, Richard Vandlen, Philip E. Hass, Xiaoting Wang
Abstract: The present invention is related to detecting respiratory diseases using molecular markers as prognostic tool of the evolution of respiratory infection cases. Concretely, during the differential diagnostic of respiratory infections caused by the Syncytial Respiratory Virus and human Metapneumovirus, it will be established the expression pattern of the severity markers of IL-3, IL-33 and IL12p40. The expression pattern of the molecular markers can be defined in biological samplers using ELISA assays, flow cytometry or PCR in real time. The confirmation of the etiological agent of the infection in combination to the pattern definition of the molecular markers IL-3, IL-33 and IL12p40 will indicate a prognostic of the disease severity.
Type:
Grant
Filed:
July 25, 2016
Date of Patent:
August 10, 2021
Assignee:
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Inventors:
Alexis Mikes Kalergis Parra, Susan Marcela Bueno Ramirez, Jose Pablo Bertrand Navarrete, Margarita Kam-Lem Lay Remolcoi
Abstract: An antibody specifically binding to IL-17A or a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IL-17A humanized antibody and a functional fragment thereof.
Type:
Grant
Filed:
September 8, 2017
Date of Patent:
July 27, 2021
Assignee:
BEIJING HANMI PHARM. CO., LTD.
Inventors:
Nanmeng Song, Jiawang Liu, Yaping Yang, Yang Yang, Dongge Yang, Hongjuan Zhang, Mengxie Jin
Abstract: The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.
Type:
Grant
Filed:
December 12, 2018
Date of Patent:
May 18, 2021
Assignees:
INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Nantes, Centre National de la Recherche Scientifique (CNRS), Université d'Angers
Abstract: The invention is concerned with a fusion protein, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein. The fusion protein or a gene therapy vector encoding the fusion protein may be used in the prevention or treatment of osteoarthritis, chronic pain, a condition characterized by local or systemic inflammation, immune activation, and/or lymphoproliferation.
Type:
Grant
Filed:
December 9, 2019
Date of Patent:
April 20, 2021
Assignee:
Synerkine Pharma B.V.
Inventors:
Joel Adrianus Gijsbert Van Roon, Sarita Aimee Yvonne Hartgring, Cornelis Erik Hack, Christina Louws, Floris Paulus Jacobus Gerardus Lafeber
Abstract: Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off level. Also described is a kit for carrying out the method.
Abstract: Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
Type:
Grant
Filed:
August 21, 2018
Date of Patent:
April 13, 2021
Assignee:
ImmunoQure AG
Inventors:
Adrian Hayday, Kai Kisand, Kai Krohn, Annalisa Macagno, Shimobi Onuoha, Paert Peterson, Mike Rothe, Martin Woodward, Syeda F. Y. Haque
Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
March 9, 2021
Assignee:
MONASH UNIVERSITY
Inventors:
Charles Reay Mackay, Di Yu, Remy Robert
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-17A (IL-17A), and provides an IL-17A binding polypeptide comprising the sequence EX2DX4AX6X7EIX10X11 LPNL X16X17X18QX20X21AFIX25 X26LX28X29. Also disclosed is the use of such an interleukin-17A binding polypeptide as a diagnostic, prognostic and/or therapeutic agent.
Type:
Grant
Filed:
January 12, 2016
Date of Patent:
March 2, 2021
Assignee:
AFFIBODY AB
Inventors:
Fredrik Frejd, Joachim Feldwisch, Susanne Klint, Lindvi Gudmundsdotter
Abstract: Antibodies which bind and neutralize human IL-33, and methods of using same, are provided, said antibodies are useful as agents for treating conditions associated with allergic disease including treating atopic dermatitis.
Type:
Grant
Filed:
October 25, 2019
Date of Patent:
February 9, 2021
Assignee:
Eli Lilly and Company
Inventors:
Robert Jan Benschop, Julian Davies, Angela Jeannine Okragly, Chetankumar Natvarlal Patel, Stephanie Marie Truhlar
Abstract: The present invention refers to a fluorescent fusion polypeptide capable of changing its localization within the cell from the cell cytoplasmic membrane to the retention vesicles, upon an increase in the concentration of second messengers within the cell cytoplasm, comprising a membrane localization peptide, a second messenger transduction protein binding peptide, a reticulum retention signal and a fluorescent peptide wherein: a. the membrane localization peptide is located at the N-terminus of the fluorescent fusion polypeptide and is physically bound, optionally through a linker, to the fluorescent peptide, which in turn is physically bound, optionally through a linker, to the second messenger transduction protein binding peptide; and b. the second messenger transduction protein binding peptide is physically bound, optionally through a linker, to the reticulum retention signal, which in turn is located at the C-terminus of the fluorescent fusion polypeptide.
Type:
Grant
Filed:
September 19, 2017
Date of Patent:
January 5, 2021
Assignee:
INNOVATIVE TECHNOLOGIES IN BIOLOGICAL SYSTEMS S.L.
Abstract: Provided herein are interleukin-13 receptor ?2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need thereof interleukin-13 receptor ?2 peptide-based brain cancer vaccines. Also provided herein are regimens comprising interleukin-13 receptor ?2 peptides and at least one additional peptide and/or immunostimulant.
Type:
Grant
Filed:
May 28, 2015
Date of Patent:
December 29, 2020
Assignee:
University of Pittsburgh—Of the Commonwealth System
Abstract: The present invention refers to a fluorescent fusion polypeptide capable of changing its localization within the cell from the cell cytoplasmic membrane to the retention vesicles, upon an increase in the concentration of second messengers within the cell cytoplasm, comprising a membrane localization peptide, a second messenger transduction protein binding peptide, a reticulum retention signal and a fluorescent peptide wherein: a. the membrane localization peptide is located at the N-terminus of the fluorescent fusion polypeptide and is physically bound, optionally through a linker, to the fluorescent peptide, which in turn is physically bound, optionally through a linker, to the second messenger transduction protein binding peptide; and b. the second messenger transduction protein binding peptide is physically bound, optionally through a linker, to the reticulum retention signal, which in turn is located at the C-terminus of the fluorescent fusion polypeptide.
Type:
Grant
Filed:
September 19, 2017
Date of Patent:
December 29, 2020
Assignee:
INNOVATIVE TECHNOLOGIES IN BIOLOGICAL SYSTEMS S.L.
Abstract: Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
Type:
Grant
Filed:
October 5, 2018
Date of Patent:
December 29, 2020
Inventors:
Adrian Hayday, Kai Krohn, Annamari Ranki, Part Peterson, Kai Kisand, Edward Stuart, Annalisa Macagno, Shimobi Onuoha
Abstract: Provided is an anti-IL 17 A/F antibody that binds to both IL-17A and IL-17F and inhibits the activities of both 1L-17A and IL-17F. The antibody comprises heavy chain CDRs 1-3 represented by SEQ ID NOs: 1-3 respectively and light chain CDRs 1-3 represented by SEQ ID NOs:4-6 respectively. The use of the antibody in the manufacture of a medicament for treating diseases associated with IL-17A and/or IL-17F in a subject, and the pharmaceutical composition comprising the antibody are also provided.
Abstract: The present invention relates to the identification of certain biomarkers for use in identifying patients who have, or are likely to develop an IL-33 mediated disease or disorder and who are more likely to respond to therapy with an IL-33 antagonist. The invention also relates to methods of treatment of an IL-33-mediated disease or disorder in a patient by administering an IL-33 antagonist to the patient in need thereof and monitoring the effectiveness of therapy using the biomarkers described herein. Also provided are methods for decreasing the level of at least one biomarker in a subject suffering from an IL-33-mediated disease or disorder, and methods for treating such diseases or disorders according to the expression levels of one or more biomarkers. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-33 antagonist.
Type:
Grant
Filed:
May 21, 2018
Date of Patent:
December 1, 2020
Assignee:
Regeneron Pharmaceuticals, Inc.
Inventors:
Jamie M. Orengo, Jeanne Allinne, Wen Fury, Yu Bai
Abstract: The invention is concerned with a fusion protein comprising interleukin 10 and interleukin 4, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein. The fusion protein or a gene therapy vector encoding the fusion protein may be used in the prevention or treatment of osteoarthritis, chronic pain, a condition characterized by local or systemic inflammation, immune activation, and/or lymphoproliferation.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
December 1, 2020
Assignee:
Synerkine Pharma B.V.
Inventors:
Joel Adrianus Gijsbert Van Roon, Sarita Aimee Yvonne Hartgring, Cornelis Erik Hack, Christina Louws, Floris Paulus Jacobus Gerardus Lafeber
Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
November 17, 2020
Assignee:
AnaptysBio, Inc.
Inventors:
Robert A. Horlick, David J. King, Andrew John McKnight
Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
November 10, 2020
Assignee:
Merck Patent GmbH
Inventors:
Heidi Rommelaere, Joost Alexander Kolkman, Michael John Scott Saunders, Ann Union, Yolande Chvatchko, Amanda E. I. Proudfoot, Alain Vicari, Denis Bruniquel, Laurent Chevalet, Olivier Leger
Abstract: Fusion proteins including an IL-17 receptor with a multimerization domain, or an IL-23 receptor and a multimerization domain, and recombinant viral vectors encoding such fusions, are described. The fusion proteins and vectors encoding such fusions, alone or in combination, can be used in methods for modulating the IL-17 and IL-23 signaling pathways and for treating or preventing diseases mediated by interleukin-17 and interleukin-23, such as immune-related and inflammatory diseases.