Patents Examined by Donna Wright
  • TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RAR&agr; RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY
    Patent number: 6620963
    Abstract: Compounds of the formula where the variables have the meaning defined in the specification, which bind specifically or selectively to to RAR&agr; retinoid receptors.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: September 16, 2003
    Assignee: Allergan, Inc.
    Inventors: Tien T. Duong, Richard Beard, Roshantha A. Chandraratna
  • Methods for the preparation of 4-hydroxy benzothiophene
    Patent number: 6437144
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I comprising cyclocarbonylation of a compound of formula II wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: August 20, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig