Abstract: The present disclosure proposes a pen-like assembly of caps for cleaning and protecting needle-free iv-connectors, with an extended shelf life. An enhanced gas-tightness in sealing is arranged in-between successively arranged caps that are engaged together. A first approach is based on enhancing geometric compliance between striking surfaces, by contacting one or more material components that have different respective Shore hardness values. A second approach is based on meandering and extending a possible fluid communication route from a cavity inside a cap towards surroundings of the assembly. A third approach includes the provision of the fluid communication route with an adhesive or sealant to achieve a gas-tight sealing. A fourth approach includes circumferentially covering junctions with one or more covers that are substantially gas impermeable.

Abstract: A medicine liquid transfer device includes a double-chamber syringe, a dispensing needle assembly, and a syringe needle sealing assembly. The medicine liquid transfer device features an exquisite structural design and easy assembly, enables fully-closed medicine preparation and transfer, and allows automatic or manual adjustment and balance of the air pressure inside the medicine container in use, thereby minimizing the risk of medicine leakage and providing an excellent leakproof effect, while having advantages of low cost, high convenience of use, and the like.

Abstract: A drug delivery assembly comprising a magnetic indicator and a sensor system is provided. The indicator is arranged to rotate and move axially relative to a housing component and corresponding to a reference axis, the amount of rotation being indicative of the size of an expelled dose amount. The sensor system comprises a sensor component adapted to measure a property of the indicator indicative of a rotational position and/or a rotational movement of the indicator. The sensor component forms part of release assembly adapted to be moved into engagement with a release member to release a set dose, and subsequently to move axially together with indicator.

Abstract: An injection device includes an elongated housing extending along a longitudinal axis, a piston rod to operably engage with a piston of a cartridge filled with the medicament, a dose tracker selectively operably engageable with the piston rod, wherein the dose tracker is longitudinally displaceable relative to the housing from an initial position in a proximal direction towards at least a first activation position for setting of the dose and wherein the dose tracker is longitudinally displaceable relative to the housing in a distal direction from the at least first activation position towards the initial position for dispensing of the dose, a spring to urge the dose tracker in the proximal direction relative to the housing, an interlock to lock the dose tracker in the initial position relative to the housing, and a release member to release the interlock.

Abstract: The present invention relates to a perforated plate microstructure module, and more particularly, to a perforated plate microstructure module which can be used to deliver a drug into the skin.

Abstract: An autoinjector includes a case adapted to hold a medicament container having a needle telescopically coupled to the case and movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The autoinjector includes a plunger rotationally and slidably disposed in the case rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case engages the plunger to rotate the plunger from the first rotational position to the second rotational position when the needle shroud translates from the first extended position to the retracted position. The autoinjector includes a cap removably coupled to the case includes at least one compliant case beam adapted to releasably engage at least one aperture in the case.

Abstract: Drug delivery devices and associated heating and/or cooling devices are disclosed. In an example, a drug delivery device includes a housing, a container, a therapy layer, and a first adhesive layer. The housing includes a top wall and a bottom wall. The container is at least partially disposed within the housing. The container has an inner volume to contain a drug. The therapy layer have a first side and a second side. The first side faces the bottom wall and the second side faces away from the bottom wall. The first adhesive layer couples the first side of the therapy layer and the bottom wall. The therapy layer is adapted to at least one of heat or cool an area adjacent an injection site.

Abstract: A medicament delivery device for a mixing process to create a therapeutic substance for delivery within a multi-chambered cartridge, the delivery device includes a distal part with a dose setting mechanism having a housing, a dose setting knob, an injection button, a piston rod capable of moving axially along the longitudinal axis of the housing during dose delivery, and a return ring configured to reset the piston rod to a starting position. The delivery device also includes a proximal part including a cartridge holder configured to accept a multi-chambered cartridge, the cartridge holder including a screw driven sleeve configured for attachment to the distal part and rotation of the screw driven sleeve performing a medicament mixing process within the multi-chambered cartridge.

Abstract: A drug delivery assembly comprising a sensor system in combination with an indicator arranged to rotate, the amount of rotation being indicative of the size of an expelled dose amount. The sensor system comprises a sensor assembly adapted to measure a rotational position and/or a rotational movement of the indicator, the sensor assembly comprising a sensor element adapted to be operated at a non-constant sampling frequency. A processor is configured to determine on the basis of measured values from the sensor element rotational position(s) and/or amount of rotational movement of the indicator, as well as rotational speed of the indicator. To optimize energy consumption the processor is configured to dynamically control the sampling frequency in response to the determined rotational speed.

Abstract: Disclosed is an oral drug delivery device, comprising a tubular member, a drug holding part, a device cap and a turbulence-creating means. The tubular member has openings at both ends and an inner cavity; the opening at one end is a first opening and the opening at the other end is a second opening; the inner cavity communicates the first opening and the second opening. The turbulence-creating means comprises a step structure or a fold structure, and is disposed in the inner cavity and positioned between the second opening and the drug holding part. By using the oral drug delivery device of the present invention, turbulence can be generated during a normal sipping process, thereby providing ample mixing of drug-containing granules or multi-particulates with drinkable liquids. Moreover, the device is telescopic, which reduces the size and is convenient to carry.

Abstract: A delivery system for the delivery of embolic agents to a patient includes a control valve assembly interconnecting first, second, third and fourth conduits, wherein the control valve assembly selectively moves between first, second, and third states under the control of a medical professional. In the first state, the first conduit communicates with the second conduit for transmitting a solution of embolic agents between a first syringe secured to the first conduit and a second syringe secured to the second conduit. In the second state, the second conduit communicates with the third conduit for transmitting the solution of embolic agents from the second syringe to a delivery catheter secured to the third conduit. In the third state, the third conduit communicates with the fourth conduit for flushing the delivery catheter via a third syringe, which is filled with saline, connected to the fourth conduit.

Abstract: A fluid injector system for use in administering to a patient a fluid in an injection protocol in connection with a diagnostic imaging procedure includes at least one display and a control device. The control device is programmed to determine, for each of the injection protocols performed by the fluid injector system, a component status for the at least one disposable component. The component status indicates whether use of the at least one disposable component was compliant with instructions for use applicable to the at least one disposable component. The control device is further programmed to enable the at least one display to display a compliance report. The compliance report includes one or more visual indicators providing visual feedback about compliance with the instructions for use based on the component status determined for each of the injection protocols performed using the fluid injector system.

Abstract: An apparatus includes a catheter, an introducer, and an actuator. A distal end portion of the introducer is configured to be coupled to a peripheral intravenous line. The introducer defines an inner volume having a first portion that defines an axis parallel to and offset from an axis defined by a second portion. A first portion of the actuator is movably disposed in the first portion of the inner volume. A second portion of the actuator is movably disposed in the second portion of the inner volume and coupled to the catheter movably disposed in the second portion of the inner volume. The actuator moves the catheter between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least a portion of the catheter is disposed within the peripheral intravenous line.

Abstract: Disclosed are compositions and methods for microneedle patches comprising copolymer designed for glucose triggered insulin delivery. In one aspect, disclosed herein are microneedle patches comprising insulin loaded copolymers; wherein the insulin dissociates from the microneedle in an hyperglycemic environment; wherein the copolymer comprises poly(N-vinylpyrrolidone-co-2-N(dimethylamino)ethyl acrylate-co-3-(acrylamido)phenylboronic acid and methods of their use.

Abstract: The present disclosure is generally directed to an attachment mechanism suitable for attaching for example a module to an object that is cylindrical or polygonal in cross section, e.g. to a portion of a drug delivery device. Further, the disclosure is directed to an electronic system, e.g. an electronic add-on module, which is configured to be, e.g. releasably, attached to a drug delivery device as well as an assembly comprising the electronic add-on module as well as the drug delivery device. The attachment mechanism may comprise a housing, a gripping portion with an elastically deformable sleeve and an actuator for operating the gripping portion between an open condition and a clamping condition. The actuator is configured to be operated to rotate the distal end and the proximal end of the sleeve relative to each other, thereby operating the gripping portion between the open condition and the clamping condition.

Abstract: An arrangement of drug delivery devices is provided with interchangeable members and non-interchangeable members.

Abstract: The present disclosure is directed to an electronic add-on module configured for attachment to a drug delivery device and to an assembly comprising a drug delivery device and an electronic add-on module. The electronic add-on module may comprise a first portion with a main housing defining a longitudinal axis. The module comprises a gripping mechanism allowing attachment to drug delivery device dose dial user interfaces, e.g., a dial grip, and/or drug delivery device injection user interfaces, e.g., a dose button of varying diameters and shapes. The first portion comprises on an inner side of the main housing at least two elastically deformable arms each having a clamping section which is configured to be elastically deflected radially outwards with respect to the longitudinal axis from a unstressed, nominal position to a strained, deflected position.

Abstract: An injection delivery device involves a body, a medication-containing vial within at least a portion of the body, the medication-containing vial having an open end and a closed end opposite the open end. The open end of the vial includes a seal that prevents medication contained therein from exiting the vial until delivery of the medication to a target injection site is desired. The injection delivery device also includes a plunger positioned near the open end of the vial and a needle having a passage therethrough, wherein the needle, plunger and vial are positioned relative to each other such that, during delivery of an injection, a portion of the passage will be within the plunger, and the plunger and needle will remain stationary relative to each other while the vial moves relative the plunger in a direction towards the target injection site.

Abstract: A data collection device for attachment to an injection device and for collecting medicament dosage information therefrom.

Abstract: A needleless injector configured to inject an injection intended substance to an injection target region, by injecting the injection intended substance includes a nozzle portion and a pressing portion, and a predetermined gap is formed between the nozzle portion and the pressing portion. The nozzle portion is formed to have a portion of the distal end portion that comes into contact with the injection target region and has a width (a) falling within a range from 3.5 mm to 5.5 mm, and a ratio (b/a) defined by an inner diameter (b) of a portion of a distal end portion of the pressing portion that comes into contact with the injection target region by the width (a) falls within a range from 1.5 to 5.0. A part of the injection target region is received in the predetermined gap when the pressing portion presses the injection target region.