Abstract: Described herein are methods and culture medium, useful for inducing polarization in multipotent stem cells. Additionally, described herein are multipotent cells produced by the methods and culture medium of this disclosure that are useful therapeutic agents. Also described herein are extracellular vesicles and factors secreted by multipotent cells that are produced by the methods and culture medium of this disclosure that are useful as therapeutic agents.
Type:
Grant
Filed:
September 28, 2018
Date of Patent:
April 2, 2024
Assignee:
SanBio, Inc.
Inventors:
Aline M. Betancourt, Ruth S. Waterman, Thomas F. Isett