Patents Examined by Ebenezer Sackey
-
Patent number: 10035770Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.Type: GrantFiled: April 6, 2017Date of Patent: July 31, 2018Assignee: Cytokinetics, IncorporatedInventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
-
Patent number: 10023564Abstract: Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.Type: GrantFiled: August 10, 2015Date of Patent: July 17, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Scott D. Larsen, Kristoff Homan, Helen Waldschmidt, John J. G. Tesmer
-
Patent number: 10023566Abstract: The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.Type: GrantFiled: May 26, 2015Date of Patent: July 17, 2018Assignee: EGIS GYOGYSZERGYAR ZRTInventors: Ede Laszlo Marvanyos, Attila Virag, Tamas Gregor, Balazs Volk, Maria Tothne Lauritz, Laszlo Pongo, Balazs Peregi, Gyula Lukacs, Zoltan Varga, Andras Dancso
-
Patent number: 10026905Abstract: A compound represented by Formula 1. An organic electric element includes a first electrode, a second electrode, and an organic material layer including the compound of Formula 1. The organic material layer include a light emitting layer, a hole transport layer including a compound represented by Formula 2, and an emission-auxiliary layer including the compound represented by Formula 1. When the organic electric element includes the compound in the organic material layer, luminous efficiency, color purity, and life span can be improved.Type: GrantFiled: January 14, 2013Date of Patent: July 17, 2018Assignee: DUK SAN NEOLUX CO., LTD.Inventors: Dongha Kim, Sunhee Lee, Yeonhee Choi, Soungyun Mun, Jungcheol Park, Yongwook Park, Heesun Ji, Junghwan Park, Bumsung Lee, Sunpil Hwang
-
Patent number: 10023569Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 10, 2016Date of Patent: July 17, 2018Assignee: Vertex Pharmaceuticals IncorporatedInventors: Gerald J. Tanoury, William Aloysius Nugent, Vadims Dvornikovs, Peter Jamison Rose
-
Patent number: 10016398Abstract: Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R5, R6, R8, R9, R11, X1, and X2 are as defined herein, as compounds for treatment and prevention of cancer and proliferative diseases and disorders.Type: GrantFiled: February 20, 2015Date of Patent: July 10, 2018Assignee: Frost Biologic, Inc.Inventor: Adam Siddiqui-Jain
-
Patent number: 10017477Abstract: The present invention provides kinase inhibitors, such as compounds of Formula (I) and Formula (II). The compounds may covalently or non-covalently bind a kinase (e.g., Janus kinase 3 (JAK3)). Also provided are pharmaceutical compositions, kits, methods, and uses that involve the compounds for reducing the activity of a kinase and/or treating and/or preventing a condition associated with aberrant activity of a kinase (e.g., a proliferative disease, inflammatory disorder, autoimmune disorder, painful condition, and/or viral infection).Type: GrantFiled: April 23, 2015Date of Patent: July 10, 2018Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Nathanael S. Gray, Li Tan
-
Patent number: 10016423Abstract: A solid form of Nilotinib hydrochloride, which exists as a co-crystal of nilotinib hydrochloride and levulinic acid having a molar ratio of nilotinib hydrochloride to levulinic acid of 1:2, and a process for the preparation of the co-crystal.Type: GrantFiled: October 15, 2015Date of Patent: July 10, 2018Assignee: Apotex Inc.Inventors: Matthew Pompili, David A. Stradiotto, Probal Kanti Datta
-
Patent number: 10004741Abstract: The present invention provides a solid form and composites thereof, which are useful as an inhibitor of EGFR kinases and which exhibit desirable characteristics for the same.Type: GrantFiled: January 9, 2017Date of Patent: June 26, 2018Assignee: Celgene CAR LLCInventor: Mei Lai
-
Patent number: 10005777Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.Type: GrantFiled: May 5, 2017Date of Patent: June 26, 2018Assignee: Rigel Pharmaceuticals, Inc.Inventors: Rajinder Singh, Matthew Duncton, Jing Zhang, Salvador Alvarez, Kin Tso, Sacha Holland, Rose Yen, Rao Kolluri, Thilo Heckrodt, Yan Chen, Esteban Masuda, Hui Li, Donald G. Payan, Ryan Kelley
-
Patent number: 10000480Abstract: Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition.Type: GrantFiled: October 10, 2016Date of Patent: June 19, 2018Assignee: Bristol-Myers Squibb CompanyInventors: Ryan M. Moslin, David S. Weinstein, Stephen T. Wrobleski, John S. Tokarski, Amit Kumar, Douglas G. Batt, Shuqun Lin, Chunjian Liu, Steven H. Spergel, Yanlei Zhang, Qingjie Liu
-
Patent number: 9968606Abstract: The invention provides novel chemical compounds useful for treating cancer or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.Type: GrantFiled: May 18, 2017Date of Patent: May 15, 2018Assignee: NeuForm Pharmaceuticals, Inc.Inventors: Chaoran Huang, Changfu Cheng
-
Patent number: 9969687Abstract: The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).Type: GrantFiled: December 22, 2014Date of Patent: May 15, 2018Assignee: Norgine B.V.Inventors: Rajagopal Bakthavatchalam, Manas Kumar Basu, Ajit Kumar Behera, Chandregowda Venkateshappa, Christopher Alexander Hewson, Sanjay Venkatachalapathi Kadnur, Sarkis Barret Kalindjian, Bheemashankar Kulkarni, Rohit Saxena, Juluri Suresh, Vellarkad Viswanathan, Mohd Zainuddin, Akila Parvathy Dharshinis, Rajenda Kristam
-
Patent number: 9968599Abstract: The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.Type: GrantFiled: November 20, 2015Date of Patent: May 15, 2018Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Said M. Sebti, Nicholas J. Lawrence, James Turkson
-
Patent number: 9966540Abstract: A condensed cyclic compound is represented by Formula 1. An organic light-emitting device includes the condensed cyclic compound represented by Formula 1. X, Y1, Y2, A, B, and R1 of Formula 1 are described herein. An organic light-emitting device including an organic layer including the condensed cyclic compound may have low driving voltage, high efficiency, high brightness, and long lifespan.Type: GrantFiled: July 22, 2014Date of Patent: May 8, 2018Assignees: Samsung Display Co., Ltd., Pusan National University Industry-University Cooperation FoundationInventors: Jae-Hong Kim, Myeong-Suk Kim, Sung-Wook Kim, Jin-Soo Hwang, Hong-Suk Suh
-
Patent number: 9920015Abstract: The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.Type: GrantFiled: March 11, 2014Date of Patent: March 20, 2018Assignees: NUTRICHEM COMPANY LIMITED, SHANGYU NUTRICHEM CO., LTD.Inventors: Jianwei Chen, Wenjun Wang, Jianhong Chi, Yongchang Zhao, Xufang Deng, Long Wang, Wentao Jin, Guobin Chen
-
Patent number: 9920041Abstract: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.Type: GrantFiled: February 22, 2017Date of Patent: March 20, 2018Assignee: Rigel Pharmaceuticals, Inc.Inventors: Hui Li, Thilo J. Heckrodt, Yan Chen, Darren John McMurtrie, Vanessa Taylor, Rajinder Singh, Pingyu Ding, Rose Yen
-
Patent number: 9853229Abstract: A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X1 and X2 are selected from alkyl, cycloalkyl, alkoxy, amino, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof; X1 and X2 are independently bonded to *C by an atom selected from C, N, O, S, and P; X1 and X2 are optionally joined to form a ring; and Y is selected halide, alkyl, cycloalkyl, alkoxy, amino, phosphine, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof. A formulation containing compound having a structure according to formula (I), and a device with an organic layer comprising disposed between an anode and a cathode, that includes a compound having a structure according to formula (I) are also described.Type: GrantFiled: September 5, 2014Date of Patent: December 26, 2017Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Mark E. Thompson, Peter I. Djurovich, Valentina Krylova
-
Patent number: 8399469Abstract: The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.Type: GrantFiled: April 26, 2007Date of Patent: March 19, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takuji Bando, Satoshi Aoki, Junichi Kawasaki, Makoto Ishigami, Youichi Taniguchi, Tsuyoshi Yabuuchi, Kiyoshi Fujimoto, Yoshihiro Nishioka, Noriyuki Kobayashi, Tsutomu Fujimura, Masanori Takahashi, Kaoru Abe, Tomonori Nakagawa, Koichi Shinhama, Naoto Utsumi, Michiaki Tominaga, Yoshihiro Ooi, Shohei Yamada, Kenji Tomikawa
-
Patent number: RE43596Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: GrantFiled: April 23, 2007Date of Patent: August 21, 2012Assignee: G.D. Searle LLCInventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw