Abstract: A particulate co-processed unattrited microcrystalline cellulose:hydrocolloid composition wherein the respective components are present in a weight ratio of from about 99:1 to 70:30. The composition is useful as a spheronizing agent for producing spheroids of uniform size and sphericity and having high drug loadings. The composition is produced by drying a slurry of the microcrystalline cellulose in an aqueous solution of the hydrocolloid. The preferred hydrocolloid is methylcellulose.
Type:
Grant
Filed:
September 26, 1994
Date of Patent:
March 10, 1998
Assignee:
FMC Corporation
Inventors:
David F. Erkoboni, Scott A. Fiore, Thomas A. Wheatley