Patents Examined by Edward J. Webman
  • Patent number: 7316821
    Abstract: A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: January 8, 2008
    Assignee: Purdue Pharma, L.P.
    Inventors: Benjamin Oshlack, Mark Chasin, Frank Pedi, Jr.
  • Patent number: 7307043
    Abstract: An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one nitroimino- or nitroguanidino-compound in free form or in agrochemically useful salt form and a blend of the following components, by weight: a) 2-10% of a surface-active agent comprising a1) at least one anionic surfactant; b) 4-20% of at least one inorganic solid carrier; and c) 3-25% of at least one antifreeze agent. In one embodiment, the aqueous composition further comprises a fungicidally effective amount of at least one fungicidally active compound. The inventive composition is storage stable, ready-to-apply (RTA), ecologically and toxicologically favorable and has good fungicidal efficacy.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: December 11, 2007
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Christian Schlatter, Ravi Ramachandran
  • Patent number: 7244418
    Abstract: A composition for forming an antimicrobial artificial nail, a method for preparing the same, and a method for treating a microbial infection of a nail plate are provided. The composition comprises a binder component; a filler component which polymerizes to form an acrylic matrix subsequent to contact with the binder component; and an antimicrobial agent available for diffusion from the acrylic matrix.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: July 17, 2007
    Assignee: Woodward Laboratories, Inc.
    Inventors: David Dyer, Kenneth B. Gerenraich
  • Patent number: 7229630
    Abstract: The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: June 12, 2007
    Assignee: Novalar Pharmaceuticals, Inc.
    Inventors: Andrew X. Chen, Julius Knowles, Eckard Weber
  • Patent number: 7226615
    Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: June 5, 2007
    Assignee: CryoLife, Inc.
    Inventors: K. Ümit Yüksel, Ana T. Bird, Kirby S. Black
  • Patent number: 7202281
    Abstract: The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: April 10, 2007
    Assignee: Synthemed, Inc.
    Inventors: Daniel Cohn, Eli Pines, Anna Hotovely
  • Patent number: 7201923
    Abstract: A liquid encapsulant component which contains an active, sensitive encapsulant, such as a live microorganism or an enzyme dissolved or dispersed in a liquid plasticizer is admixed with a plasticizable matrix material. The matrix material is plasticizable by the liquid plasticizer and the encapsulation of the active encapsulant is accomplished at a low temperature and under low shear conditions. The active component is encapsulated and/or embedded in the plasticizable matrix component or material in a continuous process to produce discrete, solid particles. The liquid content of the liquid encapsulant component provides substantially all or completely all of the liquid plasticizer needed to plasticize the matrix component to obtain a formable, extrudable, cuttable, mixture or dough. Removal of liquid plasticizer prior to extrusion is not needed to adjust the viscosity of the mixture for formability.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: April 10, 2007
    Assignee: General Mills, Inc.
    Inventor: Bernhard H. van Lengerich
  • Patent number: 7192604
    Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: March 20, 2007
    Assignee: Ethicon, Inc.
    Inventors: Kelly R. Brown, Iksoo Chun, Joseph J. Hammer, Victor F. Janas, Jennifer Mandanas, Mora C Melican, Alireza Rezania, Mark C. Zimmerman
  • Patent number: 7192599
    Abstract: The present invention relates to cosmetic and pharmaceutical oil-in-water emulsions which have a mattifying effect when applied to the skin. The invention comprises a hydrophilic, non-organically modified magnesium aluminum silicate or a bentonite clay and a polyol in the water phase; and a volatile, skin-compatible, lipophilic solvent and a high melting point lipophilic plasticizer in the oil phase. A preferred surfactant system to stabilize the emulsion includes non-toxic metal alkyl sulfates and/or sucrose esters.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: March 20, 2007
    Assignee: MMP, Inc.
    Inventors: Michel F. Mercier, Paul Thau, John A. Chase
  • Patent number: 7189413
    Abstract: Degradable blend of polycaprolactone and crystallization modifier especially suitable for use in the controlled release of biologically active proteins
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: March 13, 2007
    Assignee: Genzyme Corporation
    Inventors: Pericles Calias, Robert J. Miller, James R. Olson
  • Patent number: 7189414
    Abstract: The invention relates to synchronous drug delivery composition comprising a polymeric matrix which comprises hydrogel blended with a hydrophobic polymer, so as to form an erodible matrix, a drug, and, optionally, an agent which enhances intestinal drug absorption and/or an agent which inhibits intestinal drug degradation, wherein erosion of the erodible matrix, permits synchronous release of the drug, the hydrogel and the intestinal drug absorption agent and/or the agent which inhibits intestinal drug degradation.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: March 13, 2007
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Abraham Rubinstein, Michael Friedman, Muhammad Baluom, Boaz Tirosh
  • Patent number: 7172770
    Abstract: The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: February 6, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ying Ma, Kenneth J. Balkus, Jr.
  • Patent number: 7169411
    Abstract: A composition for facilitating delivery of biological agents, comprising a therapeutic or diagnostic agent and a supramolecular complex, the latter comprising (i) a block copolymer, having at least one nonionic, water soluble segment and at least one polyionic segment, and (ii) at least one charged surfactant having hydrophobic groups. The charge of the surfactant is opposite to the charge of the polyionic segment of the block copolymer. The constituents of the supramolecular complex are bound by interaction between the opposite charges thereof and between surfactant hydrophobic groups. The therapeutic or diagnostic agent may be an ionic substance, in which case the ionic substance has a net charge opposite to that of the block copolymer, the net charge being no more than 10.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: January 30, 2007
    Assignees: The University of Nebraska Board of Regents, McGill University, The Moscow State University
    Inventors: Alexander V. Kabanov, Adi Eisenberg, Victor A. Kabanov
  • Patent number: 7163699
    Abstract: The invention concerns a progestin co-micronized with a surfactant and a pharmaceutical composition comprising said gestagenic. The invention also concerns methods for preparing same.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: January 16, 2007
    Assignee: Laboratories Besins International
    Inventor: Jerome Besse
  • Patent number: 7160557
    Abstract: A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: January 9, 2007
    Assignee: Acusphere, Inc.
    Inventors: Howard Bernstein, Donald Chickering, Sarwat Khattak, Julie Straub
  • Patent number: 7153522
    Abstract: Percutaneous sorbefacients comprising hexylene glycol and 1-menthol, more particularly, percutaneous sorbefacients for female hormones or derivatives thereof; and preparations for percutaneous absorption which comprise a styrene/isoprene/styrene block copolymer and/or polyisobutylene, a softener and a tackifier as the base components, hormones, in particular, follicle hormone and/or luteal hormone as the drug component and hexylene glycol and 1-menthol as a sorbefacient.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: December 26, 2006
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Yasuhiro Ikeura, Masayoshi Maki
  • Patent number: 7153518
    Abstract: Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: December 26, 2006
    Assignee: Regeneration Technologies, Inc.
    Inventors: John F. Wironen, Chris Seid, Rebecca Jaw, Thien Doan, Gregg Ritter, Russell S. Donda
  • Patent number: 7150881
    Abstract: Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: December 19, 2006
    Assignee: Mylan Technologies, Inc.
    Inventors: Sharad K. Govil, Ludwig J. Weimann
  • Patent number: 7138133
    Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: November 21, 2006
    Assignee: The Procter & Gamble Company
    Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Francis Joseph David Bealin-Kelly, Jayant Eknath Khanolkar, Benoit Maurice Mullet, Shane Michael DE LA Harpe, Brian James Robbins
  • Patent number: 7138106
    Abstract: Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellulose acetate butyrate, nitrocellulose and copolymers of urethane/carbonate and copolymers of styrene/maleic acid.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: November 21, 2006
    Assignee: Mirco Therapeutics, Inc.
    Inventors: Scott Evans, Richard J. Greff, James I. Wright