Patents Examined by Edward Webman
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Patent number: 7361362Abstract: The present invention is an emulsified composition comprising (a) 0.01-5 wt % polysiloxane-polyoxyalkylene copolymer, (b) 0.05-1 wt % nonionic surfactant, (c) 10-30 wt % humectant, and (d) 1-50 wt % urea. The present invention provides an emulsified formulation of a urea-containing emulsified composition that has a superior emulsifying ability even with a lowered blend ratio of the surfactant, suppresses tingling due to urea, and is good feeling of use without stickiness even with a high blend ratio of the humectant.Type: GrantFiled: March 13, 2001Date of Patent: April 22, 2008Assignee: Shiseido Company, Ltd.Inventor: Takaaki Bamba
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Patent number: 6592891Abstract: Plaster for topical use having an analgesic activity and at the same time being able to re-absorb haematomas, comprising: a substrate layer; an adhesive layer in the form of a hydrogel matrix containing a pharmaceutically acceptable diclofenac salt, heparin or a heparinoid; a protective film which can be removed at the moment of use.Type: GrantFiled: April 14, 2000Date of Patent: July 15, 2003Assignee: Altergon S.A.Inventors: Elisabetta Donati, Irina Rapaport
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Patent number: 5470568Abstract: Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival.Type: GrantFiled: February 13, 1992Date of Patent: November 28, 1995Assignee: Arch Development CorporationInventor: Raphael C. Lee
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Patent number: 5346703Abstract: Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.Type: GrantFiled: August 31, 1992Date of Patent: September 13, 1994Assignee: Mediventures, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
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Patent number: 5338549Abstract: Psyllium husk-containing powdered drink mix compositions comprising a free radical scavenging antioxidant material to reduce the incidence of vacuum generation in air tight containers and of off-odors.Type: GrantFiled: December 21, 1992Date of Patent: August 16, 1994Assignee: The Procter & Gamble CompanyInventors: Lee A. Hord, Robert E. Barron
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Patent number: 5334390Abstract: Method for alleviating symptoms of nicotine withdrawal employing calcium carbonate.Type: GrantFiled: November 5, 1992Date of Patent: August 2, 1994Inventors: Neil Solomon, Theodore C. Solomon, Allen J. Freed
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Patent number: 5334392Abstract: The invention relates to a matrix tablet for the sustained release of indapamide which ensures a continuous and uniform release of the active principle after oral administration.Type: GrantFiled: June 9, 1992Date of Patent: August 2, 1994Assignee: Adir et CompagnieInventors: Alain Cuine, Bruno H. de Barochez, David Guez
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Patent number: 5326555Abstract: A clear hair spray composition exhibiting low drying times and low tack during use consisting essentially of, by weight of the composition,(a) 0-10% of a fixative resin that is a linear homopolymer or random copolymer including a monomer selected from the group consisting of a vinyl monomer and an acrylate monomer,(b) 0.01-10% of a hydrolyzed crosslinked maleic anhydride-C.sub.1 -C.sub.5 alkyl vinyl ether copolymer,(c) 10-99.99% water, and(d) 0-80% alcohol.Type: GrantFiled: March 22, 1993Date of Patent: July 5, 1994Assignee: ISP Investments Inc.Inventors: Eugene E. Hardy, Edward W. Walls, Jr.
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Patent number: 5316772Abstract: An oral pharmaceutical composition comprises a core containing a drug, a first inner layer coating on the core which contains a drug, and a second inner layer coating on the first inner layer coating which also contains drug. This oral pharmaceutical composition is used especially for treating intestinal diseases.Type: GrantFiled: December 2, 1991Date of Patent: May 31, 1994Assignee: Solvay & Cie, S.A. (Societe Anonyme)Inventors: Raymond W. Jurgens, Jr., Roger D. Graben, Adnan S. Sabir
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Patent number: 5316774Abstract: A composition for the controlled release of an active substance comprises a polymeric particle matrix, where each particle defines a network of internal pores. The active substance is entrapped within the pore network together with a blocking agent having physical and chemical characteristics selected to modify the release rate of the active substance from the internal pore network. In an exemplary embodiment, drugs may be selectively delivered to the intestines using an enteric material as the blocking agent. The enteric material remains intact in the stomach but will degrade under the pH conditions of the intestines. In another exemplary embodiment, the sustained release formulation employs a blocking agent which remains stable under the expected conditions of the environment to which the active substance is to be released.Type: GrantFiled: December 9, 1991Date of Patent: May 31, 1994Assignee: Advanced Polymer Systems, Inc.Inventors: Robert P. Eury, Rajesh Patel
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Patent number: 5316773Abstract: The solid preparation of the invention is prepared by dissolving 3-[3-(6-Benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl]-1-ethoxymethyl-5- fluorouracil (hereinafter referred to as "BOF-A2") and a water-soluble polymer in a organic solvent completely, followed by forming preparation of amorphous powder prepared by removing the organic solvent.The solid preparation is useful to enhance solubility of BOF-A2 and to accomplish rapid absorption of BOF-A2 through the alimentary canal.Type: GrantFiled: March 16, 1992Date of Patent: May 31, 1994Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Toru Nishibayashi, Yoshihiro Ishizue, Kozo Ishida, Masanori Kubo
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Patent number: 5306501Abstract: Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.Type: GrantFiled: November 8, 1991Date of Patent: April 26, 1994Assignee: Mediventures, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Robert S. Levinson
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Patent number: 5306490Abstract: A cyanoacrylate adhesive is applied to the skin areas prone to blistering prior to blister formation.Type: GrantFiled: April 20, 1992Date of Patent: April 26, 1994Assignee: Medlogic, Inc.Inventor: Leonard V. Barley, Jr.
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Patent number: 5304381Abstract: A polyprenyl compound having formula (1) is stabilized by a tocopherol, an organic acid, a neutral amino acid or a basic amino acid: ##STR1## in which n is an integer of 1 to 3.Type: GrantFiled: March 2, 1990Date of Patent: April 19, 1994Assignee: Eisai Co., Ltd.Inventors: Keizo Uesugi, Nobutaka Noda, Michiru Tanaka, Masanori Kayano
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Patent number: 5302371Abstract: A fluorescent organosilicon compound derived from the reaction of an aminofunctional organopolysiloxane and a fluorescent labeling reagent in which the fluorescent labeling reagent is incorporated into the molecule of the aminofunctional organopolysiloxane by means of a sulfonamide linkage. A method of treating hair is also disclosed in which the fluorescent organosilicon compound is applied to hair and the treated hair is examined for fluorescence under ultraviolet light in order to determine the extensiveness of deposition of the fluorescent organosilicon compound.Type: GrantFiled: August 10, 1992Date of Patent: April 12, 1994Assignee: Dow Corning CorporationInventors: Jo A. Lamb, Maris J. Ziemelis
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Patent number: 5300295Abstract: Aqueous gel drug delivery compositions and medical devices, useful for treating an eye condition, having hyperosmotic, iso-osmotic or hypo-osmotic characteristics in the gel state, are obtained by calculating the osmolality required in the liquid state to reach a desired osmotic force in the gelled state by assuming that a polyoxyalkylene block copolymer does not contribute to the osmolality in the gel state.Type: GrantFiled: September 13, 1991Date of Patent: April 5, 1994Assignee: Mediventures, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Robert S. Levinson
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Patent number: 5300286Abstract: A silicone oil-in-water emulsion composition and a method of topically treating human skin with the composition. The emulsion constitutes water, a silicone oil, and at least two nonionic emulsifiers. Each nonionic emulsifier is a solid at room temperature. One nonionic emulsifier has an HLB value less than 8.0, while the other nonionic emulsifiers has an HLB value greater than 15.0.Type: GrantFiled: July 14, 1992Date of Patent: April 5, 1994Assignee: Dow Corning CorporationInventor: Ronald P. Gee
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Patent number: 5298259Abstract: A polymer composition having a biopolymer subunit entrapped in a swellable polymer matrix is described. The composition may be supplied in a disposable cartridge, for use in delivering a solution of the subunit in an automated biopolymer synthesis operation.Type: GrantFiled: November 5, 1991Date of Patent: March 29, 1994Assignee: Applied Biosystems, Inc.Inventors: David H. Lloyd, Robert J. DeFranco
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Patent number: 5298260Abstract: Iso-osmotic, hyperosmotic, or hypo-osmotic, pH balanced, thermoreversible gels are ideal medical devices or vehicles for drug delivery to the skin of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the measured osmolality in the liquid state.Type: GrantFiled: June 9, 1992Date of Patent: March 29, 1994Assignee: Mediventures, Inc.Inventors: Tacey X. Viegas, Lorraine E. Reeve, Robert S. Levinson
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Patent number: 5296228Abstract: Sustained release pharmaceutical compound delivery compositions and methods for their production are disclosed wherein ion exchange resin particles are loaded with releasably bound pharmaceutical compounds and incorporated in an aqueous reversibly gelling polymeric solution. The pores of the ion exchange resin are sufficiently small to lock in the pharmaceutical compound without exposure to the large polymer molecules. The pharmaceutical compound remains bound within the pores of the ion exchange resin particles until after administration to a target tissue site where small ions migrate into the pores and initiate an exchange reaction.Type: GrantFiled: March 13, 1992Date of Patent: March 22, 1994Assignee: Allergan, Inc.Inventors: Nienyuan J. Chang, Kenneth J. Himmelstein