Patents Examined by Einar Stoce
  • Lipoprotein associated phospholipase A.sub.2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 5981252
    Abstract: The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: November 9, 1999
    Assignee: SmithKline Beecham
    Inventors: Colin Houston MacPhee, David Graham Tew
  • Methods of modulating melanin synthesis
    Patent number: 5962417
    Abstract: Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence encoding a peptide, that modulates the protein kinase C-beta-mediated activation of tyrosinase, the rate-limiting enzyme in melanogenesis.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: October 5, 1999
    Assignee: Trustees of Boston University
    Inventors: Barbara A. Gilchrest, Hee-Young Park
  • Rhodospirillum rubrum poly-.beta.-hydroxyalkanoate synthase
    Patent number: 5849894
    Abstract: Isolated DNA fragments encoding a Rhodospirillum rubrum (ATCC 25903) polyhydroxyalkanoate (PHA) synthase, or biologically functional equivalents thereof, are provided. Also provided is the deduced amino acid sequence of the R. rubrum PHA synthase. These molecules are useful in the production of PHAs in bacteria and plants.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: December 15, 1998
    Assignee: Monsanto Company
    Inventors: Thomas E. Clemente, Ganesh M. Kishore, Timothy A. Mitsky, David M. Stark