Patents Examined by Elilzabeth C. Weimar
  • Peptides and antibodies that inhibit platelet adhesion
    Patent number: 5114842
    Abstract: A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPPIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: May 19, 1992
    Assignee: The Scripps Research Institute
    Inventors: Edward F. Plow, Mark H. Ginsberg