Abstract: A method for extracting a carious lesion area from sound regions of a tooth. In one embodiment, the method includes generating a digital image of the tooth; identifying tooth regions; extracting a suspicious lesion area by using a marker-controlled watershed algorithm or by using a morphological bottom-hat based method along with a multi-resolution surface reconstruction method; and removing false positives. In another embodiment, the method includes generating a digital image of the tooth comprising obtaining a fluorescence image of the tooth, obtaining a reflectance image of the tooth, and combining image data for the fluorescence and reflectance images; identifying tooth regions; extracting suspicious lesion areas; and removing false positives.

Abstract: The present invention uses a microprocessor, a memory storage device, and a segmentation program comprising a plurality of program modules containing computer-readable instructions that cause the microprocessor to measure the spatial offsets between all pairs of scans in an m-mode image of a blood vessel with a cross-correlation function, convert the spatial offsets to a relative wall motion waveform through a global optimization procedure, and then translate the relative wall motion waveform to an absolute wall motion waveform by interpolation over the m-mode image. The resulting detailed absolute wall distension waveform may be beneficially rendered (e.g., superimposed) on the m-mode ultrasound image for display (e.g., on a printer and/or video monitor) and diagnostic purposes, and has enormous potential for enhancing existing techniques for identifying and studying vascular biomarkers, such as vessel wall strain and compliance.

Abstract: A method of aggregating and using medical device data from a plurality of remote institutions. The system and method electronically receives at a central computer system a plurality of established medical device data, each of the plurality of established medical device data being received from a respective medication delivery system, each of the respective medication delivery systems having a respective plurality of medical devices within the respective remote institution, such as medication delivery pumps, associated therewith and utilized therein. The system and method electronically combines and stores the plurality of established medical device data from each of the plurality of remote institutions within a memory, and electronically provides a remote client computer access to at least one of a central reporting application adapted for providing summary information to the remote client computer about the medical device data, and/or other applications.

Abstract: Unfilled prescriptions are submitted to a registry comprising pre-qualified pharmacies for a “reverse auction” in which the pharmacies bid for the opportunity to fill the prescription. The pharmacies or a network of pharmacies on behalf of the pharmacies are allowed to bid based on price and/or offering ancillary services. The auction may also be used to bid on supplying specified pharmaceutical cognitive services. The method may also include obtaining cost comparisons with generic substitutes or similar alternative pharmaceutical products. The system may further comprise automatically requesting a review by the prescriber for a list of similar substitutes or prior-authorization for third-party payers. The winner of the reverse auction is selected by the customer.

Abstract: A method of aggregating and using medical device data from a plurality of remote institutions. The system and method electronically receives at a central computer system a plurality of established medical device data, each of the plurality of established medical device data being received from a respective medication delivery system, each of the respective medication delivery systems having a respective plurality of medical devices within the respective remote institution, such as medication delivery pumps, associated therewith and utilized therein. The system and method electronically combines and stores the plurality of established medical device data from each of the plurality of remote institutions within a memory, and electronically provides a remote client computer access to at least one of a central reporting application adapted for providing summary information to the remote client computer about the medical device data, and/or other applications.

Abstract: A method for determining the legitimacy of an insurance claim includes the steps of receiving codes that identify a service for which payment is requested from an insurance provider. Services that might have been upcoded or miscoded to the claimed service are also identified. An insured, a patient or a family member or care giver can be queried about the occurrence of observable aspects of the service that is billed as well as a service that might have been upcoded to what is billed. Responses to the queries suggest the legitimacy or illegitimacy of the claim.

Abstract: An evaluative software tool to support the assessment of health care-related technologies during development to facilitate making critical decisions for an optimized research, development and commercialization plan is provided. The software tool includes the ability to measure, weight, and integrate the critical factors that come into play in the development of a risk/benefit profile of a technology relative to its competitors, benchmarked around clinical trial measures, in order to determine its development and commercialization success.

Abstract: A method for analyzing a tissue specimen that includes obtaining a first digital tissue sample image and a second digital tissue sample image showing a first and a second tissue sample, respectively. The first tissue sample and the second tissue sample are stained for a first biomarker and a second biomarker, respectively. Both digital tissue sample images are analyzed to identify portions of the first tissue sample positive for the first biomarker and for the second biomarker, respectively. A co-expression analysis to create a biomarker co-expression profile. The co-expression analysis identifies at least a portion of the tissue specimen positive for both the first biomarker and the second biomarker, at least a portion of the tissue specimen positive for only the first biomarker, and at least a portion of the tissue specimen positive for only the second biomarker. The biomarker co-expression profile is displayed.

Abstract: A method is provided for determining whether a third party is authorized to access information representative of genetic data. This information representative of genetic data is associated with a physical sample and is provided in an accessible format. A set or access rights is received that define which third parties can access the information and how the information can be used. A third party requests to access the information for the purposes of performing a test. The request is compared to the access rights. If the third party is authorized, the test is performed on the information. If, however, the third party is not authorized, access is denied.

Abstract: A method of aggregating and using medical device data from a plurality of remote institutions. The system and method electronically receives at a central computer system a plurality of established medical device data, each of the plurality of established medical device data being received from a respective medication delivery system, each of the respective medication delivery systems having a respective plurality of medical devices within the respective remote institution, such as medication delivery pumps, associated therewith and utilized therein. The system and method electronically combines and stores the plurality of established medical device data from each of the plurality of remote institutions within a memory, and electronically provides a remote client computer access to at least one of a central reporting application adapted for providing summary information to the remote client computer about the medical device data, and/or other applications.

Abstract: The disclosure presents a system and method for efficiently capturing, tracking, analyzing, and providing continuous quality improvement in an integrated manner in relation to errors which occur in the distribution of medication to patients through a multi-store pharmacy operation. The system and method include receiving error event data for a pharmacy error event through a first input device at a pharmacy through an input interface, transmitting the error event data to a pharmacy error event database associated with a pharmacy error event computer and storing the error event data in the pharmacy error event database.

Abstract: The present invention provides a method of determining a treatment program for a subject. The method includes obtaining subject data representing the subject's condition. The subject data is used together with a model of the condition, to determine system values representing the condition. These system values are then used to determining one or more trajectories representing the progression of the condition in accordance with the model. From this, it is possible to determine a treatment program in accordance with the determined trajectories.

Abstract: Unfilled prescriptions are submitted to a registry comprising pre-qualified pharmacies for a “reverse auction” in which the pharmacies bid for the opportunity to fill the prescription. The pharmacies are allowed to bid based on price and/or offering ancillary services. The auction may also be used to bid on supplying specified pharmaceutical cognitive services. The method may also include obtaining cost comparisons with generic substitutes or similar alternative pharmaceutical products. The system may further comprise automatically requesting a review by the prescriber for a list of similar substitutes or prior-authorization for third-party payers. The winner of the reverse auction is selected by the customer. A prescription benefits manager may offer options of a reverse auction, or non-auction fulfillment of the unfilled prescription in accordance with a benefit plan design.

Abstract: Computerized methods in a clinical computing environment for predicting mortality in critically ill patients, that is, patients admitted to Intensive Care Units, are provided. In accordance with embodiments hereof, at least two distinctly different mortality prediction models (e.g., the Acute Physiology and Chronic Health Evaluation (APACHE®) model and the Mortality Probability Model at Admission (MPM0) are utilized in a multi-stage fashion to determine, with better accuracy than may be provided by either mortality prediction model alone, the probability of mortality for critically ill adult patients.

Abstract: A system is implemented to collect data from a plurality of different sources. The data comprises information about episodes experienced by a plurality of consumers. The system is configured to receive a cost estimate request from a user for a specified episode. The may access the data to determine a plurality of service items for the specified episode and the associated cost of each service item. An episode may be associated with one or many service items. The network-based service may generate a response to the cost estimate request. The response may include the plurality of service items determined for the specified episode and the associated cost information. The system may send the response to the user.

Abstract: Methods and apparatus enabling organizations with a need to communicate with healthcare providers regarding health-related issues affecting patient health to notify healthcare providers of a health-related issue affecting patient health are disclosed. An electronic notification of the health-related issue is transmitted by one of the organizations to a healthcare notification network, which may include a healthcare website, for transmission to a healthcare provider, where the electronic notification includes a mechanism for obtaining an acknowledgement indicating that the healthcare provider has received and opened the electronic notification. Healthcare related information, such as drug recalls and medication warnings to healthcare providers from content providers, along with other services, is provided at the healthcare website. Healthcare related information may also be provided through other websites, such as electronic prescription and electronic medical/health records websites.

Abstract: Unfilled prescriptions are submitted to a registry comprising pre-qualified pharmacies for a “reverse auction” in which the pharmacies bid for the opportunity to fill the prescription. The pharmacies are allowed to bid based on price and/or offering ancillary services. The auction may also be used to bid on supplying specified pharmaceutical cognitive services. The method may also include obtaining cost comparisons with generic substitutes or similar alternative pharmaceutical products. The system may further comprise automatically requesting a review by the prescriber for a list of similar substitutes or prior-authorization for third-party payers. The winner of the reverse auction is selected by the customer.

Abstract: A method for providing insurance coverage to a subscriber comprises offering an insurance policy to the subscriber wherein the insurance policy comprises providing allowances to pay for one or more expenses covered by the insurance policy and providing monetary credits to the subscriber for any unused portion of a given allowance where the monetary credits can be used to cover the cost of a subsequent allowed expense. The insurance policy may be a pharmacy benefits plan. The covered expenses may be pharmacy expenses. The allowed expenses may be medical expenses which qualify under Section 213 of the US Internal Revenue Code for payment by an employer without the subscriber having to declare the payment as taxable income.

Abstract: Interactive information regarding a product in a package is provided. A unique identifier is received. The unique identifier identifies a package containing a product. Use information is generated based at least partially on stored user information regarding past use of the product.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.