Abstract: The present invention provides a method for determining whether a patient will respond to treatment with a myostatin pathway inhibitor, the method comprising: (a) determining a level of myostatin and/or activin type II receptor (ActRII) and/or follistatin in at least one muscle biopsy obtained from a treatment target muscle in a subject having or suspected of having muscle atrophy or a muscle wasting condition; and (b) determining a level of myostatin and/or follistatin in a systemic sample obtained from the patient, wherein if: (i) the level of myostatin in the systemic sample is higher than a threshold and/or if the level of follistatin in the sample is lower than a threshold; and (ii) the level of myostatin and/or ActRII receptor in the at least one biopsy sample is higher than a threshold level and/or if the level of follistatin in the at least one biopsy sample is lower than a threshold level, the patient will respond to treatment.
Type:
Grant
Filed:
March 12, 2018
Date of Patent:
July 4, 2023
Assignee:
UCL Business Ltd.
Inventors:
Thomas Voit, Julie Dumonceaux, Virginie Mariot
Abstract: The present invention relates to anti-OPG antibodies, and to methods of treatment, uses and pharmaceutical compositions comprising such antibodies, for example in the treatment and prevention of PAH.
Type:
Grant
Filed:
January 26, 2018
Date of Patent:
June 20, 2023
Assignee:
KYMAB LIMITED
Inventors:
Joana De Abreu Carvalho, Steve Holmes, Allan Lawrie
Abstract: The invention relates to the field of medical biotechnology. Specifically, the present invention relates to a fusion protein containing an anti-interleukin-17 antibody and a tumor necrosis factor receptor extracellular region, a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and the use of the fusion protein for the treatment, prevention, and/or diagnosis of a related disease in an individual.
Type:
Grant
Filed:
November 6, 2018
Date of Patent:
June 6, 2023
Assignees:
BEIJING BEYOND BIOTECHNOLOGY CO., LTD, HANGZHOU POLYMED BIOPHARMACEUTICALS, INC.
Abstract: Disclosed are compositions and methods comprising the administration of pulsed dendritic cells and an immunoregulator molecule inhibitor for the treatment of cancer.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
May 30, 2023
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., VACCINEX, INC.
Inventors:
Brian Czerniecki, Krithika N. Kodumudi, Elizabeth Evans
Abstract: The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are provided which comprise a GDF8-specific binding protein and an Activin A-specific binding protein. For example, the invention includes compositions comprising an anti-GDF8 antibody and an anti-Activin A antibody. In other embodiments, antigen-binding molecules are provided which comprise a GDF8-specific binding domain and an Activin A-specific binding domain. For example, the invention includes bispecific antibodies that bind GDF8 and Activin A. The compositions of the present invention are useful for the treatment of diseases and conditions characterized by reduced muscle mass or strength, as well as other conditions which are treatable by antagonizing GDF8 and/or Activin A activity.
Abstract: The present disclosure relates to a polypeptide including an Fc-gamma receptor mutant. The Fc-gamma receptor mutant of the present disclosure is optimized by substituting a part of an amino acid sequence of an Fc-gamma receptor with a different amino acid sequence, so as to provide an excellent selective binding ability to immunoglobulins. Therefore, it can be usefully used for increasing in vivo half-life of drugs, detecting and purifying immunoglobulins, inhibiting organ transplant rejections, or preventing or treating autoimmune diseases.
Type:
Grant
Filed:
September 13, 2018
Date of Patent:
May 16, 2023
Assignee:
KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
Inventors:
Sang Taek Jung, Migyeong Jo, Sanghwan Ko, Bora Hwang
Abstract: The invention relates to treating or preventing anaemia in a subject, such as a mammal or human. In particular, the invention addresses moderate to severe anaemia. Additionally, the invention provides means for sparing administration of erythropoiesis stimulating agents (ESAs) to subjects.
Type:
Grant
Filed:
June 1, 2017
Date of Patent:
May 16, 2023
Assignee:
Kymab Limited
Inventors:
Volker Germaschewski, Igor Theurl, Martin Yateman, Jasper Clube, Steve Arkinstall
Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Type:
Grant
Filed:
February 28, 2020
Date of Patent:
May 9, 2023
Assignee:
ACCELERON PHARMA INC.
Inventors:
Ravindra Kumar, Rajasekhar Naga Venkata Sai Suragani
Abstract: The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric anti-bodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine anti-bodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
Type:
Grant
Filed:
February 19, 2020
Date of Patent:
April 25, 2023
Assignee:
Julius-Maxmilians-Universitat Wurzburg
Inventors:
Jörg Wischhusen, Markus Junker, Tina Schäfer, Dirk Pühringer
Abstract: In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications. The disclosure also provides methods of using a GDF/BMP antagonist to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. The disclosure further provides methods of using a GDF/BMP antagonist to reduce right ventricular systolic pressure in a subject in need thereof.
Abstract: Provided herein are therapeutic methods of treatment using agonist leptin receptor (LEPR) antibodies, antigen-binding fragments thereof, or compositions comprising the LEPR antibodies or antigen-binding fragments thereof. Such therapeutic methods include treatment for conditions related to metabolic dysfunction, including for example, lipodystrophy, adiposity or obesity, reducing body weight, non-alcoholic fatty liver disease, hyperphagia, hyperglycemia, insulin resistance, dyslipidemia, hepatic steatosis, and infertility.
Type:
Grant
Filed:
April 5, 2019
Date of Patent:
March 21, 2023
Assignee:
REGENERON PHARMACEUTICALS, INC.
Inventors:
Jesper Gromada, Panayiotis Stevis, Judith Altarejos, Andrew J. Murphy
Abstract: The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.
Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis and psoriatic arthritis.
Type:
Grant
Filed:
July 30, 2020
Date of Patent:
February 7, 2023
Assignee:
The Medical College of Wisconsin, Inc.
Inventors:
Brian F. Volkman, Anthony E. Getschman, Sam T. Hwang, Yasutomo Imai, Francis C. Peterson
Abstract: Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; M1F:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.
Type:
Grant
Filed:
December 17, 2019
Date of Patent:
February 7, 2023
Assignee:
Colgate-Palmolive Company
Inventors:
Camille Zenobia, Harsh Mahendra Trivedi, Ying Yang
Abstract: The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10), or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical compositions comprising said polypeptides.
Type:
Grant
Filed:
May 17, 2019
Date of Patent:
February 7, 2023
Assignee:
CAMBRIDGE ENTERPRISE LIMITED
Inventors:
Nicholas W. Morrell, Wei Li, Paul D Upton
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
Type:
Grant
Filed:
August 15, 2019
Date of Patent:
January 31, 2023
Assignee:
Pfizer Inc.
Inventors:
Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
Abstract: The present invention provides methods and compositions for the use of IL-22 for treating conditions of intestinal injury and inflammatory conditions such as graft vs. host disease. Specifically, IL-22 can be used to increase Intestinal Stem Cell (ISC) recovery and for enhancing immune reconstitution following allogeneic hematopoietic transplantation. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22, including a dimeric form of IL-22, in therapeutic compositions for treating graft vs. host disease, including hepatic, thymic, gastrointestinal, or other graft vs. host disease in hematopoietic stem cell transplant patients and in patients with inflammatory intestinal conditions.
Type:
Grant
Filed:
December 23, 2019
Date of Patent:
January 31, 2023
Assignees:
MEMORIAL SLOAN-KETTERING CANCER CENTER, EVIVE BIOTECHNOLOGY (SHANGHAI) LTD
Inventors:
Marcel Van Den Brink, Alan Hanash, Caroline Lindemans, Tom Tang
Abstract: A reference standard set for BNP measurement, including a plurality of reference standards including BNP-32 and proBNP, wherein the ratio BNP-32/proBNP (mole ratio) differs between the reference standards, and when a reference standard having a high mole ratio and a reference standard having a low mole ratio are compared, the BNP concentration, which is the sum total of the BNP-32 concentration and the proBNP concentration, is lower in the reference standard having a high mole ratio than in the reference standard having a low mole ratio.
Abstract: The described invention provides methods for treating an inflammatory brain disease, disorder or condition and for treating a traumatic brain injury having an inflammatory component in a subject in need thereof using isolated erythropoietin (EPO)-derived oligopeptides.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
January 24, 2023
Assignees:
United States Government As Represented By The Department of Veterans Affairs, Rutgers, The State University of New Jersey
Inventors:
Peter C. Dowling, Bo Wang, Rui Rong Yuan, Wei Lu
Abstract: A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.
Type:
Grant
Filed:
April 20, 2018
Date of Patent:
January 24, 2023
Assignee:
YUHAN CORPORATION
Inventors:
Byung Hyun Choi, In Hwan Lim, Jun Young Park, Jin Hyoung Lee, Ki Hong Kim, Hae Yong Jo, Jun Hwan Kim, Moo Young Song, Jong Gyun Kim