Patents Examined by Elizabeth Kemmerer
  • Candida albicans gene, integrin-like protein, antibodies, and methods of use
    Patent number: 6774219
    Abstract: An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: August 10, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Cheryl A. Gale, Kathleen Kendrick
  • Methods of identifying or screening for agents that binds the Ob-Re
    Patent number: 6770444
    Abstract: This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for detecting nucleic acid encoding a polypeptide, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a polypeptide, nonhuman transgenic animals which express DNA encoding a normal or a mutant polypeptide, methods of isolating a polypeptide, methods of treatment eating disorders as well as methods of determining binding of compounds to polypeptides.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: August 3, 2004
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Nika Adham, Beth Borowsky, Nigel Levens, Radek Ctirad Skoda
  • Peptides with wound healing activity
    Patent number: 6767891
    Abstract: A number of peptides of from 28 to 44 amino acids, including therein a sequence of L-K-E-K-K (SEQ ID NO: 1), have a physiological activity that can be wound healing activity, immunostimulant activity, or growth factor activity. The peptides can be linear or circular, and, if linear, its amino terminus can be optionally acetylated. The invention also includes nucleic acids encoding these peptides, vectors incorporating these nucleic acid sequences, and host cells transfected with these vectors, as well as methods for producing these peptides by culturing these host cells and purifying the peptides. The invention further includes pharmaceutical compositions and methods for using these peptides.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: July 27, 2004
    Inventor: Chanda Zaveri
  • Receptor kinase, BIN1
    Patent number: 6765085
    Abstract: A novel plant steroid receptor, BIN1, is provided, as well as polynucleotides encoding BIN1. The function of BIN1, an extracellular steroid-binding receptor, is provided as well as its primary binding affinity with brassinolide. BIN1 polypeptide is useful in promoting increased plant yield and/or increased plant biomass.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 20, 2004
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joanne Chory, Jianming Li
  • Methods of use of fibroblast growth factor, vascular endothelial growth factor and related proteins in the treatment of acute and chronic heart disease
    Patent number: 6759386
    Abstract: Disclosed herein is a rational, multi-tier approach to the administration of growth factor proteins in the treatment of heart disease. Also disclosed is a method to evaluate the effectiveness of the administration of growth factor proteins comprising the clinical assay of CPK-MB levels in a patient undergoing treatment with growth factor proteins. In addition, there is disclosed a method for treatment of heart disease comprising administration of a therapeutically effective amount of a growth factor protein by oral inhalation therapy.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: July 6, 2004
    Inventor: Wayne P. Franco
  • Functionalized TGF-&bgr; fusion proteins
    Patent number: 6756215
    Abstract: This disclosure relates to TGF-&bgr; family protein fusions that display substantial native TGF-&bgr; family protein function while also having an additional functionality conveyed by the addition of a functionalizing peptide domain. Such functionalizing peptide domain can be a tag peptide (e.g., an epitope tag, a purification tag, a molecular size differentiation tag, etc.) or a passenger or targeting protein. Also provided are methods of making these fusions, as well as methods of using them for diagnosis and diagnosis of various conditions, in measuring and monitoring levels of the fusion molecule in experimental systems and subjects, and in measuring and detecting receptor proteins.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: June 29, 2004
    Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
    Inventors: Lawrence A. Wolfraim, John J. Letterio
  • Screening methods using ligands of the neutropeptide receptor HFGAN72
    Patent number: 6750026
    Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: June 15, 2004
    Assignees: SmithKline Beecham Corporation, Board of Regents The University of Texas System
    Inventors: Derk J. Bergsma, David P. Brooks, Miklos Gellai, Shelagh Wilson, Masashi Yanagisawa
  • Progesterone receptor-regulated gene expression and methods related thereto
    Patent number: 6750015
    Abstract: Disclosed are expression profiles of genes that are regulated by progesterone receptors, and particularly by progesterone receptor isoforms PR-A and PR-B. Methods for using such genes to identifying progesterone receptor agonist and antagonist ligands are described. Also described are methods for identifying isoform-specific progesterone receptor ligands, for identifying tissue-specific progesterone receptor ligands, and for determining the profile of genes regulated by progesterone receptors in a breast tumor sample. In addition, pluralities of polynucleotides from genes that are regulated by progesterone receptors are disclosed, as are pluralities of antibodies that selectively bind to proteins encoded by such genes.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: June 15, 2004
    Inventors: Kathryn B. Horwitz, Jennifer Richer
  • Modulated release particles for lung delivery
    Patent number: 6749845
    Abstract: A polymeric construct is disclosed. The construct comprises a polysaccharide polymer having a selected medicament associated therewith. The medicament thus present is provided in a slow release form.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: June 15, 2004
    Assignee: Aeropharm Technology, Inc.
    Inventors: Yaping Zhu, Simon G. Stefanos, Lukeysha Kline, Akwete L. Adjei
  • Keratinocyte growth factor-2 products
    Patent number: 6743422
    Abstract: The present invention concerns variants and chemical derivates of keratinocyte growth factor-2 (KGF-2) protein. Also disclosed are nucleic acid molecules encoding such variants, as well as methods for using such variants and chemical derivates to stimulate epithelial cell proliferation.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: June 1, 2004
    Assignee: Amgen, Inc.
    Inventors: Linda Owers Narhi, Timothy David Osslund
  • Cytokine receptor and nucleic acids encoding the same
    Patent number: 6740520
    Abstract: The present invention is directed to novel cytokine receptors having sequence similarity to AF18497_1 and to nucleic acid molecules encoding those cytokine receptors. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: May 25, 2004
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Follicle stimulating hormone-glycosylation analogs
    Patent number: 6737515
    Abstract: The invention provides recombinant native and mutein forms of human follicle stimulating hormone beta subunit (FSH beta) with characteristic glycosylation patterns which are influential in the metabolic activity of the protein. The invention also provides recombinant mutant forms of the human alpha subunit common to FSH, LH, CG, and TSH, to obtain hormones which also have unique glycosylation patterns. Also provided are recombinant materials to produce these subunits separately or together to obtain complete heterodimeric hormones of regulated glycosylation pattern.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: May 18, 2004
    Assignee: Washington University
    Inventors: Irving Boime, Martin M. Matzuk, Jeffrey L. Keene
  • Non-nuclear effects of thyroid hormone
    Patent number: 6730472
    Abstract: Truncated thyroid hormone receptors &Dgr;TR&agr;1 and &Dgr;TR&agr;2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of &Dgr;TR&agr;1 and &Dgr;TR&agr;2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: May 4, 2004
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Alan P. Farwell
  • Recombinant proteins from HGF and MSP
    Patent number: 6730657
    Abstract: Recombinant proteins derived by recombination of structural domains obtained from alpha and beta subunits of HGF and/or MSP growth factors. These recombinant proteins contain domains selected from HGF and MSP, and are useful to protect cells, including differentiated cell elements of liver, kidney, and mucosa of the gastorenteral tract, from death (i.e., apoptosis) induced by chemotherapeutics.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: May 4, 2004
    Assignee: Dompe' S.p.A.
    Inventors: Enzo Medico, Paolo Michieli, Chiara Colessi, Gianfranco Caselli, Paolo Comoglio
  • MCP-1 receptor antibodies
    Patent number: 6730301
    Abstract: Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: May 4, 2004
    Assignee: The Regents of the University of California
    Inventors: Israel R. Charo, Shaun R. Coughlin
  • Bone resorption inhibitors
    Patent number: 6723696
    Abstract: A leukocyte activating protein factor or a substance originating therein having an effect of inhibiting bone resorption; and novel medicinal utilization thereof. Use of these novel substances with the bone resorption inhibitory effect makes it possible to provide therapeutic methods efficacious against hypercalcemia, osteoporosis, etc.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: April 20, 2004
    Assignee: Japan as represented by Secretary of National Institute of Infectious Diseases
    Inventors: Kazuo Suzuki, Satoshi Yamagoe, Tooru Yamakawa
  • Antibodies that bind chemokine teck
    Patent number: 6723520
    Abstract: Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 20, 2004
    Assignee: Schering Corporation
    Inventors: Wei Wang, Kurt C. Gish, Thomas J. Schall, Alain Vicari, Albert Zlotnik
  • Luciferase reporter bioassay of parathyroid hormone compounds
    Patent number: 6720153
    Abstract: This invention is directed to a bioassay for determining the functionality of parathyroid hormone compounds. More particularly, this invention is directed to a bioassay wherein the compound to be tested is added to a culture of parathyroid hormone receptor expressing cells bearing a reporter gene under the transcriptional control of multiple c-AMP responsive elements.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: April 13, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Richard F. Labaudiniere, Kin T. Yu, Gregg R. Crumley, Clarence C. Morse
  • Nucleic acid molecule encoding homer 1B protein
    Patent number: 6720175
    Abstract: A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: April 13, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
  • Tendon-inducing compositions
    Patent number: 6719968
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 13, 2004
    Assignee: Genetics Institute, LLC.
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton