Abstract: An I.V. flush syringe assembly includes a barrel having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end including a distal wall with an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with the chamber. A plunger having an elongate body portion and a stopper slidably positioned in fluid-tight engagement with the inside surface of the barrel is provided. Anti-reflux structure in said barrel is provided for controlling stopper deflection when fluid has been delivered from the chamber and the stopper is in contact with structure on the distal wall.

Abstract: Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

Abstract: The invention relates to a device for adjustably displacing the distal end of a flexible catheter tube (1). Said device comprises a spring-elastic guide wire (2) with a spiral end section (2?) which can be displaced inside the tube (1) until the desired angle of displacement is obtained.

Abstract: A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.

Abstract: A device for positioning a bore needle into a specific position within a vein includes a first body defining proximal and distal ends. A first needle extends from the distal end, establishing fluid communication through the first body from the distal to the proximal end. A second body co-axially supports the bore needle for rotational orientation in the specific position, and has a distal end with an aperture that defines an angle relative to the longitudinal axis of the bore needle. The first and second bodies are respectively mounted to first and second opposed sides of a web body that defines an angle between the first needle and the bore needle when the bore needle is received in the second body, for positioning the aperture of the bore needle in the specific position in alignment with the first needle and opening substantially in the longitudinal direction of the first needle.

Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).

Abstract: In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors which are sold or distributed filled and with the springs tensed have to be provided with a needle protecting cap to ensure the sterility of the injection needle. When such a needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container comprising the injection needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve which accommodates the active agent container. When the auto-injector is placed onto a person's skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange and, thus, freeing the travel path for needle movement.

Abstract: An injector for liquid medicine comprises a cylindrical body 1, first and second gasket 2, 3 contained in a lumen of cylindrical body 1. The cylindrical body 1 is provided with a fluid inlet 13 and a fluid outlet 14 in opposite sides of the cylindrical body 1 with respect to the longitudinal axis thereof. Second gasket 3 is spaced from the first gasket 2 to form a fluid chamber 4 between them. The first gasket 2 is adapted to be moved by sliding along the inner wall of the cylindrical body 1 from a first position to the distal end 11 of cylindrical body 1 via a second position. The fluid inlet 13 is opened at a position closer to the distal end 11 of the cylindrical body 1 than the outlet 14 is. The first gasket 2 is stopped at a second position where the fluid chamber 4 is communicated with the fluid outlet 14 but prevented from fluid-communication with the fluid inlet 13.

Abstract: An outlet portion for nasal rinsers includes an outlet end, a connection end and a nozzle shaped channel, showing a restriction and an expanded outlet, in between.

Abstract: A syringe assembly having a retractable needle, the syringe assembly being rendered unusable after a single injection and having a hollow syringe body, a retraction mechanism with a spring disposed in the front portion of the syringe and an inner head, a continuous retainer member surrounding the inner head, and a bridging portion disposed between the continuous retainer member and the inner head, wherein the bridging portion couples the continuous retainer member and the inner head to form a fluid seal between a fluid passageway and the barrel prior to retraction, and a plunger reciprocally disposed inside the barrel and forming a variable chamber between the plunger and the needle holder prior to and during retraction, wherein the continuous retainer member is releasable from the inner head of the needle holder when the plunger is further depressed inside the barrel following injection.

Abstract: The present invention relates to an implantable drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump or valve, and a drug delivery control means. The control means in accordance with the invention is configured to initially clear a first, or old, drug from the device based on the content of the Current Profile data containing a first, or old, delivery profile. After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.

Abstract: An improved ambulatory infusion device for dispensing a fluid into a patient includes a flexible bladder enclosure including a sheath of flexible material having a first open end a closed second end. The first open end of the sheath is affixed to a rigid closure, and a bladder support is secured in fixed position relative to the closure. An elastic bladder is mounted on the bladder support and positioned inside the sheath for holding fluid to be dispensed. The closed second end of the sheath is free to conform to the body of the patient so that the device is comfortable when worn. In other aspects, a flow restrictor and a pressure regulator are provided.

Abstract: The present invention discloses a medical injector and medicament loading system for use therewith. The medicament loading system includes cap for a medicament cartridge. The cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper. The medical injector according to the present invention includes the medicament loading system, i.e., a cartridge assembly, a needle free syringe assembly, and a power pack assembly.

Abstract: An air-bubble-monitoring medication assembly includes a drug infusion subassembly having a tube for administering therein a liquid to a patient, a bubble-size determinator which is positioned to sense an air bubble entrained in the liquid in the tube and which determines the volume of the air bubble, and an analyzer. The analyzer logs the time the detector senses an air bubble and the volume of the air bubble, calculates a running sum of a total air volume of all air bubbles sensed over a time interval, compares the running sum with a preselected limit, and generates an output when the running sum exceeds the preselected limit. The medical system additionally includes a controller assembly which determines a delivery schedule for administering the liquid and which controls the drug infusion subassembly to administer the liquid in accordance with the determined delivery schedule. The method performs the analyzer functions.

Abstract: An implantable medical device for delivering a therapeutic substance to a delivery site in a patient. A reservoir holds a supply of the fluid therapeutic substance. A catheter has a proximal end, a delivery region and a lumen extending from the proximal end to the delivery region. The proximal end of the catheter is operatively coupled to the reservoir. The delivery region of the catheter is adapted to be placed proximate the delivery site in the patient. The therapeutic substance is adapted to be delivered through the lumen to the patient. A sensing device is operatively coupled with the lumen of the catheter being capable of detecting a pressure of the therapeutic substance in the lumen. A controller is operatively coupled to the sensing device, the controller being capable of taking an action in response to the pressure in the lumen.

Abstract: An administering apparatus with a dosage display, including a casing, a reservoir for a fluid product, a driven device which acts on the product, a dosing means for selecting a product dosage to be delivered which includes a dosage scale including a number of dosage marks axially spaced from each other, and a drive device coupled to the driven device for driving the driven device, the drive device performing a delivery stroke from an initial position, in a drive direction, to a delivery stopper, the length of the delivery stroke counter to the drive direction being limited by selecting the product dosage using the dosing means, wherein the casing is transparent at least in an area overlapping the dosage scale, and wherein the drive device forms an indicator to the dosage scale in order to indicate the initial position of the drive device.

Abstract: An administering apparatus for delivering a dosage of product including a casing with a reservoir for the product, a conveying device, a dosage setting member mechanically coupled to the conveying device and a stopper for the dosage setting member. The conveying device is formed by a driven device and a drive device. The driven device, a piston rod in one embodiment, is mounted by the casing such that it performs a delivery movement in the form of a delivery stroke in an advancing direction along a translational axis to deliver a product dosage selected using the dosage setting member. The delivery movement of the driven device is effected with the drive device, the drive device and the driven device being coupled.

Abstract: A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.

Abstract: An intravenous catheter introducer assembly having a safety feature to prevent accidental needle sticks. The introducer assembly includes a needle assembly having a groove disposed on its outer surface. The introducer includes a protector made of a hollow member having an open distal end and an inwardly disposed resilient flange or a clip disposed thereon. The protector is coaxially slidably disposed around the needle with the flange abutting the outer surface of the needle and adapted to engage the groove when a catheter assembly is removed from the needle.

Abstract: A device for the transport of fluids through a biological barrier includes a number of microneedles projecting from the front face of a substrate. A conduit is associated with each of the microneedles to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle. Each of the microneedles is configured to provide a penetrating tip, and each conduit terminates at an opening which is proximal with respect to the microneedle tip. Also described are microneedle-based devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.