Patents Examined by Elli Peseler
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Patent number: 4675392Abstract: An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --Halwherein Hal is chlorine, bromine or iodine, m is an integer of 2-20 inclusive and n is an integer of 1 to 10, inclusive, with the proviso that when n=1 and m=2, the aldose is different from glucose;An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --S--R--R'wherein n is an integer of from 1-10, inclusive, m is an integer of from 2-20, inclusive, R is selected from the group consisting of alkyl having at most 25 carbon atoms and aryl and R' is selected from the group consisting of H, CHO, CH(OR').sub.2, NO.sub.2, NH.sub.2, OH, SH, COOH, COOCH.sub.3, COOCH.sub.2 CH.sub.3, CONHNH.sub.2 and CON.sub.3, wherein R" is C.sub.1-4 -alkyl;A glycoconjugate having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.Type: GrantFiled: November 21, 1984Date of Patent: June 23, 1987Assignee: Svenska Sockerfabriks ABInventors: Jan Dahmen, Torbjorn Frejd, Goran Magnusson, Ghazi Noori
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Patent number: 4650790Abstract: The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. The composition comprises tiamulin hydrogen fumarate and an aminoglycoside antibiotic or a pharmaceutically acceptable salt thereof in a weight ratio of 5:1 to 1:5. The active components are admixed or diluted with a carrier, used in veterinary therapy, in a weight ratio of 1:1 to 1:50 and formulated for oral or parenteral application.Type: GrantFiled: March 28, 1985Date of Patent: March 17, 1987Assignee: Patentbureau DanubiaInventors: Ferenc Simon, Attila Romvary, Janos Varga, Laszlo Bozzay, Edit Bruckner nee Gabor
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Patent number: 4563445Abstract: The invention relates to substitution derivatives of trisaccharide 3-fucosyl-N-acetyl lactosamine and to the immunological applications of these derivatives and of the trisaccharide itself particularly as diagnostic reagent and in therapy.Type: GrantFiled: January 9, 1984Date of Patent: January 7, 1986Assignee: Choay S.A.Inventors: Ten Feizi, Hock C. Gooi, Pierre G. Sinay
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Patent number: 4554010Abstract: 5-Deoxy-3-O-arylmethyl or substituted aryl-methyl-1,2-O-substituted-alkylidene or cycloalkylidene-alpha-D-xylofuranose and 5-C-alkyl, alkylidenyl and alkenyl derivatives thereof. The compounds are useful as herbicides and plant growth regulators.Type: GrantFiled: December 7, 1983Date of Patent: November 19, 1985Assignee: Chevron Research CompanyInventor: William Loh
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Patent number: 4497649Abstract: 5-O-acyl-5-C-alkyl-3-O-substituted arylmethyl-1,2-O-alkylidene-.alpha.-D-gluco- and .beta.-L-ido-pentofuranoses. The compounds exhibit herbicidal activity and especially pre-emergence herbicidal activity against grasses.Type: GrantFiled: August 18, 1983Date of Patent: February 5, 1985Assignee: Chevron Research CompanyInventor: William Loh
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Patent number: 4481196Abstract: New phosphate derivatives represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are each hydroxy, alkoxy, alkanoylamino or protected hydroxy;A is lower alkylene;R.sup.4 is alkylammonio, cyclic ammonio or cyclic amino; andR.sup.5 is oxido anion or hydroxy;and pharmaceutically acceptable salt thereof, which exhibit antitumor activity.Type: GrantFiled: August 31, 1983Date of Patent: November 6, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Tsutomu Teraji, Eishiro Todo, Norihiko Shimazaki, Teruo Oku, Takayuki Namiki
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Patent number: 4479897Abstract: Actaplanin antibiotics (A4696) designated as C.sub.2a, D.sub.1, D.sub.2, K, L, M, N, and O are obtained by the partial acidic hydrolysis of known actaplanins at about pH 1.85 for 2.5 hours at about 90.degree. C. The new actaplanins, like the known actaplanins, are glycopeptides which possess antibacterial activity and, either alone or as a mixture with other actaplanins, improve the feed efficiency in ruminants, swine and poultry.Type: GrantFiled: April 27, 1983Date of Patent: October 30, 1984Assignee: Eli Lilly and CompanyInventors: Ann H. Hunt, Kurt E. Merkel
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Patent number: 4474948Abstract: Benzotriazoles are employed in phosphite triester oligonucleotide synthesis. The benzotriazoles also form phosphinedibenzazolides. Processes employing these reagents are also disclosed.Type: GrantFiled: April 8, 1982Date of Patent: October 2, 1984Assignee: BiosearchInventors: Derek Hudson, Ronald M. Cook
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Patent number: 4462992Abstract: Compounds of the formula: ##STR1## wherein W is selected from the group consisting of ##STR2## Wherein Q is hydrogen or --CH.sub.2 OR.sup.1 ;Z is hydrogen or --OR.sup.1 ;n is 1 or 2;wherein R.sup.1 are the same or different radicals selected from the group consisting of hydrogen, and ##STR3## where R.sup.2 is lower alkyl, aryl, or aralkyl; wherein the bond at positions 2' and 3' of structure I may be single or double; or it may be a C-nucleoside attached at 3' position of the sugar; X and Y are the same or different selected from the group consisting of hydrogen, an electron withdrawing group, and a group wherein X and Y taken together form a 6-membered carbocylic aromatic ring, are useful as radiosensitizing agents during x-ray radiotherapy of tumor cells.Type: GrantFiled: February 8, 1982Date of Patent: July 31, 1984Assignee: Research CorporationInventors: Krishna C. Agrawal, Masakazu Sakaguchi
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Patent number: 4459280Abstract: This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.Type: GrantFiled: July 23, 1982Date of Patent: July 10, 1984Assignee: G. D. Searle & Co.Inventors: John A. Colliopoulos, David B. Paul, James G. Young
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Patent number: 4438260Abstract: The invention relates to sisomicin derivatives of formula (I) and methods for their preparation. Also included in the invention are compositions containing said sisomicin derivatives and the use of said derivatives and compositions for the treatment of bacterial infections.Type: GrantFiled: December 24, 1981Date of Patent: March 20, 1984Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Peter Stadler, Oswald Lockhoff, Hans-Joachim Zeiler, Karl G. Metzger
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Patent number: 4433139Abstract: N-Acetyl-.beta.-D-glucosaminides produced from 1-chloro-1-deoxy-2,3,4,6-tetraacetyl-.alpha.-D-glucosamine and indicators for titration as the aglycons useful as substrates in kits for diagnostic aid, with which N-acetyl-.beta.-D-glucosaminidase activity can be determined colorimetrically in high sensitivity, precisely, and quickly.Type: GrantFiled: March 11, 1982Date of Patent: February 21, 1984Assignee: Shionogi & Co., Ltd.Inventors: Yasunao Ogawa, Akira Noto, Sachio Mori, Mitsuru Yoshioka
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Patent number: 4429122Abstract: The separation of mono- or disaccharides such as glucose or maltose from polysaccharides such as starch may be effected by passing a mixture of these saccharides through an ultra-filtration membrane whereby the glucose or maltose is separated from the starch. The ultra-filtration membranes which are employed for this purpose will comprise a cross-linked polyurethane composited on a support. As an example of the type of membrane which may be employed, an amine-modified polyepihalohydrin such as epichlorohydrin which has been cross-linked with toluene diisocyanate is composited on a polysulfone. This type of ultra-filtration membrane will permit the use of a relatively high flux with a good separation efficiency.Type: GrantFiled: April 20, 1982Date of Patent: January 31, 1984Assignee: UOP Inc.Inventor: Joseph J. Zupancic
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Patent number: 4425336Abstract: Cardiac contractility agents are provided which are 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamin e cyclodextrin complexes.Type: GrantFiled: May 24, 1982Date of Patent: January 10, 1984Assignee: Key Pharmaceuticals, Inc.Inventor: Ronald R. Tuttle
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Patent number: 4424209Abstract: Cardiac contractility agents are provided which are 3,4-di-isobutyryloxy-N-?3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl!-beta- phenethylamine, preferably orally deliverable forms which are cyclodextrin complexes.Type: GrantFiled: June 21, 1982Date of Patent: January 3, 1984Assignee: Key Pharmaceuticals, Inc.Inventor: Ronald R. Tuttle
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Patent number: 4418192Abstract: Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)- (1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.Type: GrantFiled: April 20, 1982Date of Patent: November 29, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Hiroshi Tanaka, Takeo Yoshioka, Yasutaka Shimauchi, Toshikazu Oki, Tomoyuki Ishikura, Tomio Takeuchi, Hamao Umezawa