Patents Examined by Elli Peseler
  • Patent number: 4675392
    Abstract: An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --Halwherein Hal is chlorine, bromine or iodine, m is an integer of 2-20 inclusive and n is an integer of 1 to 10, inclusive, with the proviso that when n=1 and m=2, the aldose is different from glucose;An O-glycoside having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.m --S--R--R'wherein n is an integer of from 1-10, inclusive, m is an integer of from 2-20, inclusive, R is selected from the group consisting of alkyl having at most 25 carbon atoms and aryl and R' is selected from the group consisting of H, CHO, CH(OR').sub.2, NO.sub.2, NH.sub.2, OH, SH, COOH, COOCH.sub.3, COOCH.sub.2 CH.sub.3, CONHNH.sub.2 and CON.sub.3, wherein R" is C.sub.1-4 -alkyl;A glycoconjugate having the general formula:(sugar).sub.n --O--(CH.sub.2).sub.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: June 23, 1987
    Assignee: Svenska Sockerfabriks AB
    Inventors: Jan Dahmen, Torbjorn Frejd, Goran Magnusson, Ghazi Noori
  • Patent number: 4650790
    Abstract: The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. The composition comprises tiamulin hydrogen fumarate and an aminoglycoside antibiotic or a pharmaceutically acceptable salt thereof in a weight ratio of 5:1 to 1:5. The active components are admixed or diluted with a carrier, used in veterinary therapy, in a weight ratio of 1:1 to 1:50 and formulated for oral or parenteral application.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: March 17, 1987
    Assignee: Patentbureau Danubia
    Inventors: Ferenc Simon, Attila Romvary, Janos Varga, Laszlo Bozzay, Edit Bruckner nee Gabor
  • Patent number: 4563445
    Abstract: The invention relates to substitution derivatives of trisaccharide 3-fucosyl-N-acetyl lactosamine and to the immunological applications of these derivatives and of the trisaccharide itself particularly as diagnostic reagent and in therapy.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: January 7, 1986
    Assignee: Choay S.A.
    Inventors: Ten Feizi, Hock C. Gooi, Pierre G. Sinay
  • Patent number: 4554010
    Abstract: 5-Deoxy-3-O-arylmethyl or substituted aryl-methyl-1,2-O-substituted-alkylidene or cycloalkylidene-alpha-D-xylofuranose and 5-C-alkyl, alkylidenyl and alkenyl derivatives thereof. The compounds are useful as herbicides and plant growth regulators.
    Type: Grant
    Filed: December 7, 1983
    Date of Patent: November 19, 1985
    Assignee: Chevron Research Company
    Inventor: William Loh
  • Patent number: 4497649
    Abstract: 5-O-acyl-5-C-alkyl-3-O-substituted arylmethyl-1,2-O-alkylidene-.alpha.-D-gluco- and .beta.-L-ido-pentofuranoses. The compounds exhibit herbicidal activity and especially pre-emergence herbicidal activity against grasses.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: February 5, 1985
    Assignee: Chevron Research Company
    Inventor: William Loh
  • Patent number: 4481196
    Abstract: New phosphate derivatives represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are each hydroxy, alkoxy, alkanoylamino or protected hydroxy;A is lower alkylene;R.sup.4 is alkylammonio, cyclic ammonio or cyclic amino; andR.sup.5 is oxido anion or hydroxy;and pharmaceutically acceptable salt thereof, which exhibit antitumor activity.
    Type: Grant
    Filed: August 31, 1983
    Date of Patent: November 6, 1984
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tsutomu Teraji, Eishiro Todo, Norihiko Shimazaki, Teruo Oku, Takayuki Namiki
  • Patent number: 4479897
    Abstract: Actaplanin antibiotics (A4696) designated as C.sub.2a, D.sub.1, D.sub.2, K, L, M, N, and O are obtained by the partial acidic hydrolysis of known actaplanins at about pH 1.85 for 2.5 hours at about 90.degree. C. The new actaplanins, like the known actaplanins, are glycopeptides which possess antibacterial activity and, either alone or as a mixture with other actaplanins, improve the feed efficiency in ruminants, swine and poultry.
    Type: Grant
    Filed: April 27, 1983
    Date of Patent: October 30, 1984
    Assignee: Eli Lilly and Company
    Inventors: Ann H. Hunt, Kurt E. Merkel
  • Patent number: 4474948
    Abstract: Benzotriazoles are employed in phosphite triester oligonucleotide synthesis. The benzotriazoles also form phosphinedibenzazolides. Processes employing these reagents are also disclosed.
    Type: Grant
    Filed: April 8, 1982
    Date of Patent: October 2, 1984
    Assignee: Biosearch
    Inventors: Derek Hudson, Ronald M. Cook
  • Patent number: 4462992
    Abstract: Compounds of the formula: ##STR1## wherein W is selected from the group consisting of ##STR2## Wherein Q is hydrogen or --CH.sub.2 OR.sup.1 ;Z is hydrogen or --OR.sup.1 ;n is 1 or 2;wherein R.sup.1 are the same or different radicals selected from the group consisting of hydrogen, and ##STR3## where R.sup.2 is lower alkyl, aryl, or aralkyl; wherein the bond at positions 2' and 3' of structure I may be single or double; or it may be a C-nucleoside attached at 3' position of the sugar; X and Y are the same or different selected from the group consisting of hydrogen, an electron withdrawing group, and a group wherein X and Y taken together form a 6-membered carbocylic aromatic ring, are useful as radiosensitizing agents during x-ray radiotherapy of tumor cells.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: July 31, 1984
    Assignee: Research Corporation
    Inventors: Krishna C. Agrawal, Masakazu Sakaguchi
  • Patent number: 4459280
    Abstract: This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.
    Type: Grant
    Filed: July 23, 1982
    Date of Patent: July 10, 1984
    Assignee: G. D. Searle & Co.
    Inventors: John A. Colliopoulos, David B. Paul, James G. Young
  • Patent number: 4438260
    Abstract: The invention relates to sisomicin derivatives of formula (I) and methods for their preparation. Also included in the invention are compositions containing said sisomicin derivatives and the use of said derivatives and compositions for the treatment of bacterial infections.
    Type: Grant
    Filed: December 24, 1981
    Date of Patent: March 20, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Peter Stadler, Oswald Lockhoff, Hans-Joachim Zeiler, Karl G. Metzger
  • Patent number: 4433139
    Abstract: N-Acetyl-.beta.-D-glucosaminides produced from 1-chloro-1-deoxy-2,3,4,6-tetraacetyl-.alpha.-D-glucosamine and indicators for titration as the aglycons useful as substrates in kits for diagnostic aid, with which N-acetyl-.beta.-D-glucosaminidase activity can be determined colorimetrically in high sensitivity, precisely, and quickly.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: February 21, 1984
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasunao Ogawa, Akira Noto, Sachio Mori, Mitsuru Yoshioka
  • Patent number: 4429122
    Abstract: The separation of mono- or disaccharides such as glucose or maltose from polysaccharides such as starch may be effected by passing a mixture of these saccharides through an ultra-filtration membrane whereby the glucose or maltose is separated from the starch. The ultra-filtration membranes which are employed for this purpose will comprise a cross-linked polyurethane composited on a support. As an example of the type of membrane which may be employed, an amine-modified polyepihalohydrin such as epichlorohydrin which has been cross-linked with toluene diisocyanate is composited on a polysulfone. This type of ultra-filtration membrane will permit the use of a relatively high flux with a good separation efficiency.
    Type: Grant
    Filed: April 20, 1982
    Date of Patent: January 31, 1984
    Assignee: UOP Inc.
    Inventor: Joseph J. Zupancic
  • Patent number: 4425336
    Abstract: Cardiac contractility agents are provided which are 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamin e cyclodextrin complexes.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: January 10, 1984
    Assignee: Key Pharmaceuticals, Inc.
    Inventor: Ronald R. Tuttle
  • Patent number: 4424209
    Abstract: Cardiac contractility agents are provided which are 3,4-di-isobutyryloxy-N-?3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl!-beta- phenethylamine, preferably orally deliverable forms which are cyclodextrin complexes.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: January 3, 1984
    Assignee: Key Pharmaceuticals, Inc.
    Inventor: Ronald R. Tuttle
  • Patent number: 4418192
    Abstract: Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)- (1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.
    Type: Grant
    Filed: April 20, 1982
    Date of Patent: November 29, 1983
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Hiroshi Tanaka, Takeo Yoshioka, Yasutaka Shimauchi, Toshikazu Oki, Tomoyuki Ishikura, Tomio Takeuchi, Hamao Umezawa