Patents Examined by Elli Peselev
  • Stevia extract or steviol for hair care
    Patent number: 8759405
    Abstract: Methods of enhancing the appearance of a mammal's hair/fur are provided by the administration of an oral nutraceutical or food composition comprising steviol or a steviol precursor, without chromene, for a time sufficient and in an amount effective to enhance the overall appearance of the mammal's hair/fur. The enhancement of the appearance of the mammal's hair/fur includes restoring hair/fur color, lessening hair loss, increasing the thickness of hair, counteracting age-associated hair thinning, and delaying the onset or severity of age-associated hair loss and thinning. A nutraceutical or food which includes steviol or a steviol precursor in an amount sufficient to enhance the overall appearance of a mammal's hair/fur is also provided.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: June 24, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Regina Goralczyk, Annis O. Mayne-Mechan, Jenny Piussi, Henry Rieger, Hasan Mohajeri
  • Antibacterial compounds, methods of making them, and uses thereof
    Patent number: 8754054
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: June 17, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: Grant J. Carr, David D. Manning, Zhicai Yang, Cheng Guo, Jun-Ho Maeng, Peter C. Michels, Matthew W. Chase
  • Polysaccharide derivative and hydrogel thereof
    Patent number: 8748409
    Abstract: Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: June 10, 2014
    Assignee: Teijin Limited
    Inventors: Hiroaki Kaneko, Masaya Ito
  • Antibacterial 4,6-substituted 6?, 6? and 1 modified aminoglycoside analogs
    Patent number: 8742078
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: June 3, 2014
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Michael T. Migawa, Xiaojing Wang, Eric E. Swayze, Richard H. Griffey
  • Compositions and methods for feeding poultry
    Patent number: 8741854
    Abstract: Feed supplements for poultry raised using a rapid growth regimen are disclosed herein. The supplements include D-ribose in an amount effective to improve the resistance to cardiomyopathy in the poultry. Methods for feeding poultry are also disclosed herein.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: June 3, 2014
    Assignee: Bioenergy, Inc.
    Inventors: John A. St. Cyr, Raj Khankari, Paul B. Addis
  • Treatments for actinic keratoses
    Patent number: 8741857
    Abstract: A composition of gentamicin and colchicine in a dermatologically acceptable cream base provided improved clearance of actinic keratoses following topical application for 1 to 3 months. The composition provides improved clearance of recalcitrant actinic keratoses. Furthermore, the treatment causes less pain and irritation than other topical treatments for actinic keratoses.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: June 3, 2014
    Inventor: Lawrence Moy
  • Fungicide composition for agriculture and horticulture and method for preventing plant diseases
    Patent number: 8741859
    Abstract: The present invention provides a composition in which a fungicidal effect against a cultivated crop infected by a plant disease is stable and highly active. An excellent agricultural or horticultural fungicide composition for controlling a plant disease is provided by using (a) at least one imidazole compound represented by formula (I): wherein R represents a C1-6 alkyl group or a C1-6 alkoxy group; and n represents an integer of 1 to 5 and (b) polyoxins as active ingredients; by combination as compared to a single use of each compound, and a plant disease is thereby controlled.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: June 3, 2014
    Assignee: Ishihara Sangyo Kaisha, Ltd
    Inventors: Shigeru Mitani, Koji Sugimoto, Yasuko Takii
  • Oligomer-nucleoside phosphate conjugates
    Patent number: 8741858
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble, non-peptidic oligomer. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: June 3, 2014
    Inventors: Zhongxu Ren, Jennifer Riggs-Sauthier, Timothy A. Riley, Laurie A. VanderVeen, Aaron S. Hammons
  • Avermectins and milbemycins for the treatment, prevention or amelioration of flavivirus infections
    Patent number: 8741856
    Abstract: Avermectin and milbemycin compounds, particularly the substance ivermectin, for preparing an antiviral medicament for the treatment, prevention or amelioration of a Flavivirus infection, such as those caused by YFV (yellow fever virus), DENV (Dengue virus), JEV (Japanese encephalitis virus), TBEV (tick-borne encephalitis virus) or MODV (Modoc virus) are provided. The antiviral compositions of the present invention are suitable for oral administration to a Flavivirus-infected subject or a subject at risk of a infection, such as a human or other mammal.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: June 3, 2014
    Assignees: Consiglio Nazionale Delle Ricerche, Aix-Marseille Universite', Katholieke Universiteit Leuven-K.U. Leuven R&D
    Inventors: Mario Milani De Mayo De Mari, Eloise Mastrangelo, Martino Bolognesi, Xavier De Lamballerie, Boris Pastorino, Johan Neyts, Suzanne Kaptein
  • Use of compounds extracted from L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
    Patent number: 8722634
    Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: May 13, 2014
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
    Inventors: Yang Ye, Minjia Tan, Changqiang Ke, Tong Chen, Xiqiang Li, Edward Kraegen, Jiming Ye, David James, Gregory Cooney
  • Methods and compositions for inhibiting progression to chronic cardiac failure
    Patent number: 8710018
    Abstract: Provided herein are methods and formulations for preventing or ameliorating progression to chronic heart failure subsequent to cardiac stress, including as a consequence of myocardial infarction (MI), coronary artery disease, hypertension, cardiomyopathy, myocarditis, valvular regurgitation, severe lung disease, and/or severe anemia of chronic disease, by administration of one or more rate-limiting precursors to the synthesis of ATP. In one embodiment the ATP precursor is a pentose selected from one or more of ribose, D-ribose, ribulose, xylitol, xylulose, and a 5-carbon precursor of ribose.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: April 29, 2014
    Inventor: John E. Foker
  • Topical antibiotic composition for the prevention of Lyme disease
    Patent number: 8710019
    Abstract: The invention relates to topical pharmaceutical compositions and methods related to Borrelia burgdorferi toxins, in particular, the present invention provides compositions and methods for the treatment of infections caused by Borrelia burgdorferi and in particular for the prevention of Lyme disease.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: April 29, 2014
    Assignee: Ixodes AG
    Inventors: Gustave Huber, Uta Hüttenes, Caroline Roosens-von Bidder
  • Pharmaceutical powder compositions
    Patent number: 8710028
    Abstract: A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: April 29, 2014
    Assignee: Archimedes Development Limited
    Inventors: Peter James Watts, Yu-Hui Cheng, Alan Smith, Jonathan Castile
  • Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof
    Patent number: 8703737
    Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: April 22, 2014
    Assignee: Abbott Laboratories
    Inventors: Rachael Buck, Geralyn O. Duska-McEwen, Joseph P. Schaller
  • Compositions and methods of treating viral infections
    Patent number: 8697670
    Abstract: The present invention relates to the field of nutraceuticals, and in particular to nutraceuticals comprising sulfated polysaccharides, Astragalus polysaccharides, resveratrol, and combinations thereof. These compositions find use in inducing physiological responses such, decreasing body fat, increasing lean body mass, alleviating the symptoms of colds, preventing the onset of colds, increasing energy, increasing the feeling of well-being in subjects, and improving skin tone and appearance.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: April 15, 2014
    Assignee: Life Science Nutrition AS
    Inventor: Jan Remmereit
  • Chlorination of carbohydrates and carbohydrate derivatives
    Patent number: 8691797
    Abstract: Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n?1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 8, 2014
    Assignee: Lexington Pharmaceuticals Laboratories, LLC
    Inventors: William Randal Erickson, Stephen Craig Fields
  • Compositions and methods for reducing the risk of agent-induced liver toxicity
    Patent number: 8685956
    Abstract: The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: April 1, 2014
    Assignees: The Board of Trustees of The University of Illinois, The Board of Trustees of The Leland Stanford Junior University
    Inventors: Hong-Hsing Liu, Gary Allen Peltz, Guochun Liao, Timothy Alan Garrow
  • Polymeric artificial tear system
    Patent number: 8685945
    Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: April 1, 2014
    Assignee: Alcon Research, Ltd.
    Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
  • Stabilized formulation for oral administration of therapeutic agents and related methods
    Patent number: 8673866
    Abstract: Stable formulations for the oral administration of therapeutic agents, methods for administering therapeutic agents using the formulations, and methods for treating conditions and diseases using the formulations.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 18, 2014
    Assignee: The University of British Columbia
    Inventors: Kishor M. Wasan, Ellen K. Wasan
  • Use of nifuratel to treat infections caused by species
    Patent number: 8673886
    Abstract: The present invention is directed to the use of nifuratel, or a physiologically acceptable salt thereof, to treat infections caused by Atopobium species. The invention is further directed to the use of nifuratel to treat bacteriuria, urinary tract infections, infections of external genitalia in both sexes, as well as bacterial vaginosis, or mixed vaginal infections in women, when one or more species of the genus Atopobium are among the causative pathogens of those infections.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: March 18, 2014
    Assignee: Polichem SA
    Inventor: Federico Mailland