Abstract: Compositions and methods comprising ampicillin or salts and derivative thereof for the treatment of delaying the onset of type I diabetes are provided.
Abstract: Provided are: a capsule for non-ferrous metal collection that can collect a non-ferrous metal; and a method for collecting a non-ferrous metal using same. The capsule for non-ferrous metal collection comprises capsule contents and a covering section covering the capsule contents, and collects a non-ferrous metal within the capsule for non-ferrous metal collection by means of the capsule for non-ferrous metal collection being immersed in a solution containing a non-ferrous metal.
Abstract: The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.
Abstract: Provided are methods of preparing a biocompatible textured surface on a thermoplastic material comprising treating the material with a plasma and subsequently shrinking the substrate to induce formation of textures. The textured surfaces are useful in one aspect, to align cells such as stem cells.
Type:
Grant
Filed:
October 17, 2012
Date of Patent:
September 27, 2016
Assignee:
The Regents of the University of California
Inventors:
Michelle Khine, Ronald A. Li, Cheng-Wei Chen
Abstract: The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for example, but not limited to G-CSF), to mobilize hematopoietic progenitor cells for transplant or other purposes. The methods of the invention may be particularly advantageous as applied to improve the stem cell yield in so-called “poor mobilizing” patients.
Type:
Grant
Filed:
September 24, 2014
Date of Patent:
September 13, 2016
Assignee:
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: Described herein are compositions, vaccines, and methods that include use of a mutated Bordetella strain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.
Type:
Grant
Filed:
November 2, 2012
Date of Patent:
August 16, 2016
Assignees:
Institut National de la Sante et de la Recherche Medicale, Institut Pasteur de Lille, National University of Singapore
Abstract: A method of damaging cell structure of an aquatic substance includes: providing an aquatic substance raw material, where the aquatic substance raw material includes an aquatic substance; adjusting a water content in the aquatic substance raw material to form an aquatic substance slurry to be processed; placing the aquatic substance slurry to be processed in a pressure container; introducing a compressed gas into the pressure container to enable the compressed gas and the water in the aquatic substance slurry to be processed to form an acidic fluid, and making the cell structure of the aquatic substance hydrolyzed and damaged by the acidic fluid; and performing a depressurizing step to separate the compressed gas.
Type:
Grant
Filed:
November 26, 2014
Date of Patent:
August 16, 2016
Assignee:
METAL INDUSTRIES RESEARCH & DEVELOPMENT CENTRE
Abstract: The present invention aims to provide a DPP-4 inhibitor that is obtained by using a food as a raw material and that is suitable for oral ingestion from the viewpoints of flavor and absorbability, and a composition for the prevention and/or amelioration of diabetes which contains the DPP-4 inhibitor. The present invention provides a DPP-4 inhibitor obtained by treating an azuki bean or a kidney bean with a microorganism or a proteolytic enzyme produced by the microorganism. In particular, a preferable DPP-4 inhibitor can be obtained by hydrolyzing an azuki bean with a koji mold or a proteolytic enzyme derived from the koji mold to fragment a protein in the azuki bean.
Abstract: Described herein are methods and compositions for high efficiency transfection of siRNA into a cell population. Such methods and compositions utilize a low voltage pre-conditioning pulse to modulate the efficiency of siRNA transfection. In some embodiments, the methods and compositions permit spatial and temporal control of siRNA transfection efficiency within a population of cells. The disclosed methods and compositions, in some embodiments, are amenable to high throughput applications such as siRNA library-based phenotypic screening.
Type:
Grant
Filed:
September 25, 2013
Date of Patent:
July 26, 2016
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The present invention relates dry granulated cell culture media which do not comprise peptones or tryptones, especially to dry granulated cell culture media formulations that support the growth of mammalian, and/or insect and/or plant cells. The present invention further relates to the production of these dry granulated cell culture media and their use.
Type:
Grant
Filed:
November 18, 2011
Date of Patent:
July 26, 2016
Assignee:
MERCK PATENT GMBH
Inventors:
Michael Howard Rayner-Brandes, Xiaojian (David) Zhao
Abstract: A method of treating ulcerative colitis or Crohn's disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of adherent cells from a placenta or adipose tissue, thereby treating the ulcerative colitis or Crohn's disease.
Abstract: A cell preparation containing mesenchymal stem cells whose immunosuppression ability is maintained is produced by means of a serum-free or low-serum culture. A method for producing a cell preparation containing mesenchymal stem cells, comprising the steps of: (A) proliferating mesenchymal stem cells in a serum-free medium “A” containing an FGF, a PDGF, a TGF-?, an HGF, an EGF, at least one phospholipid, and at least one fatty acid; and (B) screening mesenchymal stem cells whose immunosuppression ability is maintained or improved, from the mesenchymal stem cells thus proliferated in the step (A).
Abstract: Several mutated strains of Scheffersomyces stipitis are generated by repetitive culturing of the parent strain on two types of concentrated hydrolyzates and with ethanol-challenged xylose-fed continuous culture. Isolates collected from various enriched populations are screened and ranked based on relative xylose uptake rate and ethanol yield. Ranking on hydrolyzates with and without nutritional supplementation is used to identify those isolates with best performance across diverse conditions.
Type:
Grant
Filed:
January 29, 2014
Date of Patent:
March 29, 2016
Assignees:
The United States of America, as represented by the Secretary of Agriculture, Board of Trustees of Michigan State University
Inventors:
Patricia J. Slininger, Stephanie R. Thompson, Venkatesh Balan, Leonardo Da Costa Sousa, Bruce Dale, Maureen A. Shea-Andersh, Bruce S. Dien
Abstract: The invention relates to a process for obtention of myofibroblasts. According to this process: (a) a sample of cells essentially comprising fibroblasts is prepared; and (b) this sample of cells is cultured in a serum-free culture medium. The main purpose addressed by the invention is to obtain a population of myofibroblasts, the characteristics whereof facilitate any study of these cells, and in particular as pure as possible a population of myofibroblasts. Some examples of application of the invention are: identification of biomarkers of myofibroblasts, identification of therapeutic targets, identification and validation of anticancer compounds, and an in vitro model for the screening of pharmaceutical or cosmetic compounds.
Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce an intermediate or product, e.g., by fermentation.
Abstract: Methods, systems, and articles for selective three dimensional (3D) biopatterning are disclosed. A biological target may be imaged and a selected area of the image may define a desired pattern for guiding the emission of EM radiation into the biological target. Two or more groups of photosensitive elements responsive to different activation wavelengths may be provided. The photosensitive elements may be selectively activated on or within the biological target based on location and activation wavelength in order to guide cell differentiation, adhesion of growth factors to a scaffold, release of growth factors, and/or deletion of cells.
Abstract: The present invention relates to the application of a platelet gel for augmenting or restoring the volume of a soft tissue, particularly breast tissue, to biological implants comprising said gel, to a kit for preparing said implants and to a process for preparing said implants.
Type:
Grant
Filed:
June 11, 2010
Date of Patent:
December 1, 2015
Assignees:
Banc De Sang I Teixits, Fundacio Institut EN Ciencies De La Salut Germains Trias I Pujol, Universitat Autonoma De Barcelona
Inventors:
Juan Francisco Julián Ibáñez, Jorge Navinés López, Joan Ramon Grífols Ronda
Abstract: Disclosed are methods of preparing multi-cellular three-dimensional tissue constructs, that include fibroblasts, endothelial cells, lymphocytes and epithelial cells. The present methods may include embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins to form a cell containing matrix that is then added to a bioreactor and exposed to epithelial cells and activated lymphocytes as the cell cultures. Also provided are the tissue constructs formed from such methods, a matrix enriched with gut basement membrane proteins and kits that include the same. Further provided are methods of measuring toxicity of a pathogen or commensal organisms, chemosensitivity of tissues to a toxic material and inflammatory conditions, which use the present multi-cellular three-dimensional tissue constructs.
Abstract: Methods, compositions and kits are provided for generating inner ear cells in vitro. These methods find use a number of applications, such as in preparing inner ear cells for in vitro screening for agents that are toxic to inner ear cells, for in vitro screening for agents that prevent against, mitigate, or reverse the toxic effects of such agents, and for in vitro screening for agents that promote otoregeneration.
Type:
Grant
Filed:
January 23, 2012
Date of Patent:
October 13, 2015
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Stefan Heller, Mohammad Ronaghi, Kazuo Oshima