Abstract: The application relates to a tube for being introduced into an object. The tube (1), which is preferentially a catheter, comprises a tube-like braid (2) made from electrically conductive strands (3), wherein ends (4) of the strands (3) are staggered in the longitudinal direction of the tube (1). Since the ends of the strands are staggered in the longitudinal direction of the tube, local radio frequency heat generated during a magnetic resonance imaging procedure is not concentrated at a single longitudinal location, but distributed along a staggered region in the longitudinal direction of the tube, in which the ends of the electrically conductive strands are staggered. This distribution of the radio frequency heat along the longitudinal direction of the tube reduces the maximum temperature produced by radio frequency heating and, thus, the likelihood of damaging the object, in which the tube is to be introduced, due to heat.

Abstract: A medical puncture needle includes an end portion including a needle tip; and a main body portion contiguous with the end portion, having a substantially circular cross-sectional outer shape. The end portion includes a first bevel formed by a curved surface, the bevel having an angle that gradually decreases toward the needle tip in an axial direction, in a cross-section orthogonal to the axial direction, relative to an imaginary plane that extends along an axis of the main body portion.

Abstract: An assembly for a drug delivery device is provided, the assembly having an actuator which is configured to perform a setting movement in a proximal direction in order to set a dose of a drug, and which is configured to perform a dispense movement in a distal direction in order to dispense a dose of a drug. The assembly further having a stop mechanism acting after a maximum amount of a drug has been delivered, which is configured to axially constrain the setting movement of the actuator such that the setting of a dose is inhibited, wherein a limited axial movement of the actuator is allowed.

Abstract: A liner (100) for use in a breast interface (70) comprises a front section (110) including a front wall part (112) defining a breast contact surface (118) and an opening (116b) provided in the breast contact surface. The breast contact surface (118) is configured to abut a woman's breast during use, while a nipple of the breast protrudes at least partially through the opening (116b). The breast interface further comprises a rear section (170), connected to the front section (140), that includes a tubular wall part (171) having a rear end opening. The front and rear sections (110, 170) together define a milk passage (190) that extends from the opening (116b) in the breast contact surface (118) to the rear end opening of the tubular wall part (171), wherein the milk passage slopes downwardly in the rearward direction.

Abstract: A microcatheter for delivery of embolic fluids includes an outer member dimensioned for insertion within a blood vessel adjacent an embolization site. The outer member defines a first longitudinal lumen, and an inner member is selectively positionable within the first longitudinal lumen of the outer member. The inner member defines a second longitudinal lumen and has a delivery port in fluid communication with the second longitudinal lumen for passage and delivery of embolic fluids toward the embolization site. A valve is disposed within the outer member. The valve is dimensioned to establish a substantial seal about the inner member, to minimize entry of the embolic fluids within the first longitudinal lumen of the outer member subsequent to delivery thereof toward the embolization site.

Abstract: A medicament delivery device is presented having a housing, and a medicament container holder arranged movable in a longitudinal direction in relation to the housing. The medicament container holder is arranged to accommodate a medicament container, is arranged as a multi-chamber container having a medicament and a diluent in different chambers, a plunger rod operably arranged to act on the medicament container, a retaining element capable of releasably retaining the plunger rod to the housing, actuation force elements capable of, upon activation, moving the medicament container holder in relation to the housing such that the plunger rod acts on the medicament container for mixing the medicament and the diluent.

Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.

Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

Abstract: A recoil reducing needle shield for covering a drug container with a needle includes an outer shell, including an upper portion, a lower portion, and at least one flexible interface positioned therebetween, defining a fulcrum. Radially inward flexing of the upper portion causes radially outward flexing of the lower portion about the flexible interface. An inner cover includes an open proximal end, a closed distal end, and a needle cavity defined therein for receiving a portion of the drug container including the needle. At least a portion of the inner cover is disposed within the outer shell. The open proximal end of the inner cover is coupled to the lower portion of the outer shell, such that radially outward flexing of the lower portion stretches the open proximal end of the inner cover, thereby reducing an initial pull-off force required to remove the needle shield from the drug container.

Abstract: A drug delivery device for dispensing a dose of a medicament may include an elongated housing extending in an axial direction to accommodate a cartridge containing a medicament to be dispensed, wherein the housing being further adapted to detachably support a needle assembly at a distal end thereof, a drive mechanism comprising a piston rod to operably engage with a piston of the cartridge, a protecting sleeve slidably attached to the distal end of the housing to enclose the needle assembly in a distal stop position and to expose the needle assembly in a retracted proximal stop position, and an interlocking member operably engaged with the protecting sleeve and being axially displaceable relative to the housing between a locking position, in which the protecting sleeve is locked to the housing, and a release position, in which the protecting sleeve is axially displaceable relative to the housing.

Abstract: A new process of manufacturing a hybrid cannula may include creating a first part with at least two components, overmolding at least two components of a second part to a channel in each component of the first part, and fixing the components of the first part together. The second part may include various types of features such as thick/thin dams, squirt membranes, and/or duck bill dams inside the hybrid cannula. Each dam may have any number, shape, orientation, and length of slits/openings. The slits/openings may allow passage of an instrument while the dam(s) may prevent fluid from passing through the hybrid cannula. A third part may optionally be overmolded to at least a portion of the first part, at least a portion of the second part, or both. The third part may provide an extension, a flange, or a combination thereof at a distal end of the hybrid cannula.

Abstract: This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Abstract: A catheter insertion device includes a hollow needle having a distal skin-piercing end opposite a proximal base end, and an insertable catheter that is extended by a spring loaded plunger. A housing for the catheter insertion device includes a slot which extends from a slot open end to a slot closed end with a slot turn there between. At least a portion of the slot extending from the slot open end to the slot turn is non-linear with respect to a longitudinal axis of the hollow needle. A plunger moves with a button and a portion of the button is configured to be movable within the slot between a stored position, an armed position and an extended position. The plunger is configured to rotate about the longitudinal axis of the needle as the portion of the button passes through the non-linear portion of the slot.

Abstract: An assembly for a drug delivery device is provided, the assembly comprising an actuator which is configured to perform a setting movement in a proximal direction in order to set a dose of a drug, and which is configured to perform a dispense movement in a distal direction in order to dispense a dose of a drug. The assembly further comprises stop mechanism acting after a maximum amount of a drug has been delivered, which is configured to axially constrain the setting movement of the actuator such that the setting of a dose is inhibited, wherein a limited axial movement of the actuator is allowed.

Abstract: Actuators for steerable medical devices are disclosed that not only deflect or steer a portion of a medical device (e.g., a distal portion of a catheter shaft), but also include mechanisms for actively returning the deflected portion of the medical device to an initial configuration (e.g., straight or substantially straight). These active return-to-straight mechanisms may return a catheter shaft from a deflected configuration to a substantially straight configuration throughout a medical procedure, may employ one or more tension members extending along the catheter shaft, and may comprise a gross return actuator and a fine return actuator. For example, the gross return actuator may be configured to partially reverse the deflection of the distal portion of the catheter; and the fine return actuator may be configured to continue reversing the deflection. The gross return actuator may automatically trigger or actuate (mechanically or electromechanically) the fine return actuator.

Abstract: Several embodiments disclosed herein relate to the delivery of therapeutic nucleic acids to an ocular tissue in order to provide a therapeutic effect to reduce symptoms of or otherwise alleviate an ocular disorder. In particular embodiments, plasmid DNA is delivered to the cells of the trabecular meshwork in order to ameliorate increasing intraocular pressure. Devices and systems to accomplish this delivery are also disclosed.

Abstract: A medical device, such as a Huber-type device, includes a structure that enhances operator safety by reducing the likelihood that a needle will accidentally injure an operator. In one embodiment, the device includes a collapsible structure that can move from a use position to a non-use position. The device includes first and second wing portions and a channel for covering the needle as it is extracted from the patient. The structure enables the operator to leverage applied pressure for a smooth removal of the needle into the device for safe disposal.

Abstract: A catheter has a deflection beam and a single continuous puller wire to effectuate bi-directional deflection. A joint between a catheter body and a deflectable distal section effectively transmits torque from a control handle. The joint includes two open-shaped brackets, each affixed to a respective side of the flat deflection beam to form a closed-shaped hollow body that bridges and circumferentially encircles the beam. Each bracket has through-holes into which thermoplastic material of the catheter body and the deflectable distal section can melt and migrate to form interlocking nodes.

Abstract: A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal.

Abstract: The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.