Abstract: Soluble covalent HCV NS3-NS4A complexes comprising the catalytic domain of native HICV NS3 protease fused to an HCV NS4A cofactor, wherein the cofactor has been modified to prevent cleavage by the HCV NS3 protease.
Type:
Grant
Filed:
May 12, 1995
Date of Patent:
December 1, 1998
Assignee:
Schering Corporation
Inventors:
Bimalendu Dasmahapatra, Nancy J. Butkiewicz