Patents Examined by Eric Linnell
  • Liposome targeting using receptor specific ligands
    Patent number: 5258499
    Abstract: Delivery vehicle formulations comprise active agents encapsulated within liposomal vesicles to which are attached protein hormones (ligands) such as interleukin-2. The ligands are capable of showing affinity for specific cell receptors resulting in delivery of the encapsulated active agent to target cells, enabling delivery of active agents to particular cell populations in the treatment of conditions such as immune system disorders.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: November 2, 1993
    Assignee: Vestar, Inc.
    Inventors: Paula J. Konigsberg, Leroy L. Richer, Paul G. Schmidt, Joseph A. Uliana
  • Inhibitors of farnesyl protein transferase
    Patent number: 5238922
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: August 24, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Samuel L. Graham, S. Jane deSolms, Victor M. Garsky