Patents Examined by Eric Olson
  • Patent number: 11684608
    Abstract: The present invention relates to furazidin for vaginal use in the treatment of a bacterial vaginal infection. Preferably, the bacterial vaginal infection is caused by Gardnerella vaginalis and/or Atopobium vaginae bacteria.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: June 27, 2023
    Assignee: ADAMED PHARMA S.A.
    Inventors: Sylwia Berdzik-Kalarus, Daniel Sulikowski
  • Patent number: 11684630
    Abstract: A synthetic composition for use in improving one or more co-morbid mental disorder symptoms of a patient with IBS, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: June 27, 2023
    Assignee: GLYCOM A/S
    Inventors: Bruce McConnell, Emma Elison, Louise Kristine Vigsnæs
  • Patent number: 11685761
    Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 27, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Brian M. Andresen, Frank Bennett, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Jongwon Lim, Min Lu, Benjamin Wesley Trotter, Wen-Lian Wu
  • Patent number: 11660347
    Abstract: The present disclosure provides a siRNA for inhibiting the expression of apolipoprotein C3 (ApoC3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: May 30, 2023
    Inventors: Hongyan Zhang, Shan Gao, Daiwu Kang
  • Patent number: 11660312
    Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing ?-1-6-glucan as an effective ingredient, a probiotic strain producing ?-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: May 30, 2023
    Inventors: Sin-Hyeog Im, Ravi Verma, Changhon Lee
  • Patent number: 11655311
    Abstract: This specification discloses process for obtaining maltodextrin having DE between 17 and 19.9 and the maltodextrins obtained from the process. The disclosed maltodextrins can be provided as a powder or in shelf stable liquid form. The disclose maltodextrins have a polysaccharide profile similar to those observed for prior art maltodextrins, but make maltodextrin solutions having a high solids content, but reduced viscosity compared to prior art maltodextrins, on equivalent solids-in-solution basis. The process combines adds an alpha-amylase and a pullulanase enzyme to a polysaccharide mixture during a saccharification step. The disclosed maltodextrins make solutions at 50° C. and greater than 65% on a solids dry solids basis having a viscosity between 5,000 and 12,000 cP and having a water activity of less than 0.80.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 23, 2023
    Assignee: Corn Products Development, Inc.
    Inventors: Laercio Arnoni, Jose Bertoli, Walter Yamamoto
  • Patent number: 11608387
    Abstract: The present application belongs to a technical field of modifying natural polymer materials, provides a high-viscosity lithium carboxymethyl cellulose and preparation method therefor and application thereof. Raw materials are fed into a reactor, and the high-viscosity lithium carboxymethyl cellulose is prepared through an alkalization reaction, an etherification reaction, an acidification reaction and a substitution reaction. The prepared high-viscosity lithium carboxymethyl cellulose can be used for preparing a negative electrode plate of a lithium-ion battery. Compared with the existing lithium carboxymethyl cellulose, the high-viscosity lithium carboxymethyl cellulose provided by the present application can not only reduce an application amount in preparing a negative electrode plate of a lithium-ion battery so as to save a using cost, but also promote an electrochemical performance of the material in combination with a sodium lignin sulfonate.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: March 21, 2023
    Assignee: Chongqing Lihong Fine Chemicals Co., Ltd
    Inventors: Zhenzhen Nie, Yinfeng Xia, Youqi Li, Haitao Zhang, Kun Du, Qing Yu, Zilai Zhou, Wei Liu, Yuming He, Jing Zhang
  • Patent number: 11608385
    Abstract: A method is provided for the post-treatment of nanoporous celluloses with an eye to scale up to plant operation wherein recycling and recovery of reagents is crucial in the efficient and cost effective operation of a full-scale plant. The instant method includes diminishing the alkali (e.g., sodium hydroxide) concentration of the treatment solution by converting it to a salt (e.g., a sodium salt).
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 21, 2023
    Inventors: Rajai H. Atalla, Rowan S. Atalla
  • Patent number: 11591410
    Abstract: A cellulose derivative having a long-chain organic group having 5 or more carbon atoms and a short-chain organic group having 4 or less carbon atoms which are introduced by use of hydroxy groups of a cellulose, and including a crystal structure derived from a cellulose derivative portion to which the short-chain organic group is linked, wherein an average number of hydroxy groups per glucose unit is of 1.0 or less.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: February 28, 2023
    Inventors: Kiyohiko Toyama, Masatoshi Iji, Shukichi Tanaka
  • Patent number: 11591594
    Abstract: Recent advancements in LNA oligonucleotides include the use of amine linkers to link an LNA antisense oligonucleotide to a conjugate group. For example please see WO2014/I18267. The present invention originates from the identification of a problem when de-protecting LNA oligonucleotides which comprise an aliphatic amine group and DMF protected LNA G nucleoside, which results in the production of a +28 Da impurity. This problem is solved by using acyl protection groups on the exocyclic nitrogen of the LNA-G residue, rather than the standard DMF protection group.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 28, 2023
    Assignee: Roche Innovation Center Copenhagen A/S
    Inventors: Dennis Jul Hansen, Joerg Hoernschemeyer, Jacob Ravn, Christoph Rosenbohm
  • Patent number: 11584803
    Abstract: A fine cellulose fiber in which when the fine cellulose fiber is formed into a dispersion, the dispersion has very high light transmittance and viscosity, and a method for producing the fine cellulose fiber. The fine cellulose fiber has a fiber width of 1 to 200 nm. A part of hydroxy groups of the cellulose fiber are substituted with a predetermine functional group to introduce an ester of phosphorus-oxo acid, and the introduction amount of the functional group is more than 2.0 mmol per 1 g of the cellulose fiber. For producing the fine cellulose fiber, to cellulose fiber is added a solution having a pH of less than 3.0 and including an additive (A) containing at least one of a phosphorus-oxo acid and a phosphorus-oxo acid metal salt and an additive (B) containing at least one of urea and a urea derivative, and the mixture is heated to perform fibrillation.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: February 21, 2023
    Assignee: Daio Paper Corporation
    Inventor: Ikko Matsusue
  • Patent number: 11584956
    Abstract: Selectively controllable cleavable linkers include electrochemically-cleavable linkers, photolabile linkers, thermolabile linkers, chemically-labile linkers, and enzymatically-cleavable linkers. Selective cleavage of individual linkers may be controlled by changing local conditions. Local conditions may be changed by activating electrodes in proximity to the linkers, exposing the linkers to light, heating the linkers, or applying chemicals. Selective cleaving of enzymatically-cleavable linkers may be controlled by designing the sequences of different sets of the individual linkers to respond to different enzymes. Cleavable linkers may be used to attach polymers to a solid substrate. Selective cleavage of the linkers enables release of specific polymers from the solid substrate. Cleavable linkers may also be used to attach protecting groups to the ends of growing polymers. The protecting groups may be selectively removed by cleavage of the linkers to enable growth of specific polymers.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 21, 2023
    Inventors: Karin Strauss, Bichlien Hoang Nguyen
  • Patent number: 11572381
    Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 7, 2023
    Assignee: The University of Montana
    Inventors: David Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab
  • Patent number: 11566042
    Abstract: Compositions and compounds of nucleoside phosphoramidites and modified oligonucleotides, each comprising one or more charge-neutralizing moieties according to the formula V The nucleoside phosphoramidites permit facile attachment of the neutralizing moieties on the backbones of the modified oligonucleotides. The modified oligonucleotides can be used as therapeutic agents (i.e., oligotherapeutics) for the treatment of cancer, autoimmune disorders, genetic diseases, infectious diseases, neurological diseases, inflammatory diseases, metabolic diseases and others.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: January 31, 2023
    Assignee: ZATA Pharmaceuticals, Inc
    Inventors: David R. Tabatadze, Ivan B. Yanachkov
  • Patent number: 11564897
    Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: January 31, 2023
    Assignees: ALIOPHARM S.R.L., Consiglio Nazionale delle Ricerche
    Inventors: Gian Luigi Russo, Fabrizio Tarricone, Idolo Tedesco
  • Patent number: 11549133
    Abstract: The disclosure relates to a preparation method of a amylodextrin and belongs to the technical field of starch chemical modification. According to the method, de-clustering and complexation effects of ultrasonic waves are used to achieve de-clustering of a starch chain and complexation of an amorphous region and an emulsifier, and then ?-amylase and pullulanase are used to achieve complex enzymolysis. Because the amorphous region and the emulsifier form a complex which is resistant to enzymolysis, the amorphous region is prevented from being destroyed. Finally, dextrins of different molecular weights are separated by a membrane separation method, so as to obtain a amylodextrin product with low polydispersity coefficient and narrow molecular weight distribution, and the starch comprehensive utilization efficiency is increased to 70% or above.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: January 10, 2023
    Assignee: Jiangnan University
    Inventors: Yaoqi Tian, Xintian Wang, Rongrong Ma, Jinling Zhan
  • Patent number: 11548910
    Abstract: The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. The oligonucleotide production method includes a step of subjecting a nucleoside or oligonucleotide having a pseudo solid phase-protecting group in at least one location selected from the group consisting of 2?-position, 3?-position, 5?-position and a nucleobase moiety and having a 5?-hydroxyl group or a 3?-hydroxyl group, to H-phosphonation to convert the 5?-hydroxyl group or the 3?-hydroxyl group into an H-phosphonated form.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 10, 2023
    Inventor: Yudai Sugawara
  • Patent number: 11542294
    Abstract: Methods for cleaving oligonucleotides from a solid support are described as are methods for synthesizing an oligonucleotide on a solid support and subsequently cleaving the oligonucleotide from the solid support. In the methods, the 3? nucleoside of the oligonucleotide attached to the solid support is a LNA nucleoside. The method entail treating the bound oligonucleotide with a concentrated ammonium hydroxide solution for about 30 minutes to about 6 hours.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: January 3, 2023
    Assignee: Roche Innovation Center Copenhagen A/S
    Inventors: Michael Meldgaard, Marianne B. Mogensen, Dennis Jul Hansen
  • Patent number: 11542290
    Abstract: The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 3, 2023
    Inventors: David A. Bumcrot, Alfica Sehgal, Donald L. Hertzog
  • Patent number: 11524976
    Abstract: A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: December 13, 2022
    Assignee: C S Bio Co.
    Inventors: Dario Slavazza, Heng Wei Chang, Yoheng Hanson Chang