Patents Examined by Erik B Crawford
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Patent number: 10451630Abstract: Methods, devices, and systems are disclosed for performing high throughput analysis of conformational change in biological molecules or other biological entities using surface-selective nonlinear optical detection techniques.Type: GrantFiled: April 27, 2018Date of Patent: October 22, 2019Assignee: BIODESY, INC.Inventors: Joshua Salafsky, Louis J. Dietz, Ray Hebert, Dar Bahatt
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Patent number: 10449283Abstract: A cell processing system includes at least one processor connectable to a source container filled with a biological fluid, the at least one processor including a spinning membrane configured to receive and separate target cells from the biological fluid, the target cells exiting at a first outlet, one or more containers selectively connected to the first outlet; and, and a magnet. The system also includes a controller coupled to the at least one processor and configured to operate the spinning membrane to receive biological fluid from the source container and to direct the target cells to one of the one or more containers, to pause to permit magnetic particles to be associated with the target cells, and to operate the spinning membrane to receive the contents of one of the one or more containers with the magnet applied to the target cells associated with the magnetic particles.Type: GrantFiled: April 27, 2017Date of Patent: October 22, 2019Assignee: Fenwal, Inc.Inventors: Christopher J. Wegener, Bret M. Olson, Alaina Schlinker, Steven Binninger, Avnie A. Kadakia, Kyle Thompson, Kyle Wolok, Melanie Hamilton
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Patent number: 10436784Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.Type: GrantFiled: September 15, 2015Date of Patent: October 8, 2019Assignees: Meso Scale Technologies, LLC, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
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Patent number: 10429382Abstract: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. an enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.Type: GrantFiled: November 10, 2016Date of Patent: October 1, 2019Assignee: Roche Diagnostics Operations, Inc.Inventor: Juergen Klepp
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Patent number: 10422799Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: GrantFiled: December 19, 2017Date of Patent: September 24, 2019Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
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Patent number: 10422790Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventors reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventors surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: GrantFiled: December 22, 2017Date of Patent: September 24, 2019Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
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Patent number: 10422798Abstract: A problem of the present invention is to provide an immunochromatographic test strip avoiding agglutination of colloidal gold while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a hemagglutinating agent and the colloidal gold conjugates as a detection reagent, and to provide immunochromatography using the test strip. To solve the problem, the present inventors reviewed the composition of the existing reagent itself from a completely different viewpoint rather than the selection of type or amount of polyanions, and as a result of extensive study on each element, the inventors surprisingly found that agglutination of colloidal gold may be suppressed by using a particular additive without neutralization by polyanions.Type: GrantFiled: December 16, 2014Date of Patent: September 24, 2019Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Keigo Kohno, Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Marie Asami
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Patent number: 10416156Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: GrantFiled: November 29, 2016Date of Patent: September 17, 2019Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
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Patent number: 10408835Abstract: A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In some preferred embodiments, bimodal methods and devices determine if an infection is bacterial and/or viral. A dual use two strip sample analysis device includes a first lateral flow chromatographic test strip to detect MxA and a low level of C-reactive protein and a second lateral flow chromatographic test strip to detect high levels of C-reactive protein. In some preferred embodiments, the sample is a fingerstick blood sample.Type: GrantFiled: December 2, 2015Date of Patent: September 10, 2019Assignee: Rapid Pathogen Screening, Inc.Inventors: Robert P. Sambursky, Robert W. VanDine, Uma Mahesh Babu, Peter Condon
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Patent number: 10393662Abstract: A method for forming a surface-enhanced fluorescence spectroscopy (SEFS) apparatus may include depositing a plurality of surface-enhanced spectroscopy (SES) elements onto respective tips of a plurality of nano-fingers, wherein the nano-fingers are arranged in sufficiently close proximities to each other to enable the tips of a group of adjacent nano-fingers to come into sufficiently close proximities to each other to enable the SES elements on the tips to trap fluorescent probe molecules that are to bind with target molecules when the nano-fingers are partially collapsed.Type: GrantFiled: July 10, 2017Date of Patent: August 27, 2019Assignee: Hewlett-Packard Development Company, L.P.Inventors: Zhang-Lin Zhou, Lihua Zhao, Steven J. Barcelo, Zhiyong Li
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Patent number: 10393664Abstract: The present invention relates to a test system or assay system (detection system) and to a test method, preferably in use in the point-of-care (PoC) field.Type: GrantFiled: June 24, 2016Date of Patent: August 27, 2019Assignee: DST DIAGNOSTISCHE SYSTEME & TECHNOLOGIEN GMBHInventors: Lars Von Olleschik-Elbheim, Mark Hunken, Marc Dangers
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Patent number: 10386276Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.Type: GrantFiled: September 20, 2016Date of Patent: August 20, 2019Assignee: International Business Machines CorporationInventors: Stacey M. Gifford, Gustavo A. Stolovitzky, Benjamin H. Wunsch
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Patent number: 10379121Abstract: A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In some preferred embodiments, bimodal methods and devices determine if an infection is bacterial and/or viral. A dual use two strip sample analysis device includes a first lateral flow chromatographic test strip to detect MxA and a low level of C-reactive protein and a second lateral flow chromatographic test strip to detect high levels of C-reactive protein. In some preferred embodiments, the sample is a fingerstick blood sample.Type: GrantFiled: May 25, 2016Date of Patent: August 13, 2019Assignee: Rapid Pathogen Screening, Inc.Inventors: Robert P. Sambursky, Robert W. VanDine, Uma Mahesh Babu, Peter Condon
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Patent number: 10376886Abstract: Biological activity in holding pens in a micro-fluidic device can be assayed by placing in the holding pens capture objects that bind a particular material of interest produced by the biological activity. The biological material of interest that binds to each capture object can then be assessed, either in the micro-fluidic device or after exporting the capture object from the micro-fluidic device. The assessment can be utilized to characterize the biological activity in each holding pen. The biological activity can be production of the biological material of interest. Thus, the biological activity can correspond to or arise from one or more biological cells. Biological cells within a holding pen can be clonal cell colonies. The biological activity of each clonal cell colony can be assayed while maintaining the clonal status of each colony.Type: GrantFiled: December 15, 2017Date of Patent: August 13, 2019Assignee: Berkeley Lights, Inc.Inventors: Kevin T. Chapman, Daniele Malleo, J. Tanner Nevill, Steven W. Short, Mark P. White, M. Jimena Loureiro
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Patent number: 10371699Abstract: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.Type: GrantFiled: October 21, 2016Date of Patent: August 6, 2019Assignees: President and Fellows of Harvard College, United Kingdom Research and InnovationInventors: Andrew David Griffiths, David A. Weitz, Darren Roy Link, Keunho Ahn, Jerome Bibette
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Patent number: 10371701Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.Type: GrantFiled: October 13, 2017Date of Patent: August 6, 2019Assignee: abaxis, inc.Inventors: Rajesh K. Mehra, Kenneth P. Aron
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Patent number: 10359439Abstract: Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing biosample identification and analysis data, and a wireless communication interface for transferring the data to and from the biosample plate. In one embodiment, the biosample plate comprises a base for receiving a biosample, a memory component coupled to the base for storing identification and analysis information related to the biosample, and a wireless communication interface coupled to the memory component for transferring the information to and from the memory component. The wireless communication interface may include an electromagnetic device.Type: GrantFiled: July 19, 2016Date of Patent: July 23, 2019Assignee: International Business Machines CorporationInventors: Nils Haustein, Thorsten Krause, Anna W. Topol, Daniel J. Winarski
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Patent number: 10345299Abstract: The object is to provide a lysis method, lysis treatment solution, detection method using an immunochromatographic device, and detection kit comprising an immunochromatographic device for detecting whether causative bacteria of mastitis are coliform bacteria or not by using milk of a livestock animal. There is provided a method for lysing coliform bacteria, which comprises the step of mixing a lysis agent containing a lytic enzyme, and at least one kind of anionic surfactant, and preferably further containing at least one kind of nonionic surfactant, with milk obtained form a livestock animal to lyse coliform bacteria existing in the milk. The lytic enzyme is preferably lysozyme.Type: GrantFiled: December 17, 2014Date of Patent: July 9, 2019Assignee: ASAHI KASEI KABUSHIKI KAISHAInventors: Koji Maehana, Kenji Matsuyama
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Patent number: 10345303Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.Type: GrantFiled: June 16, 2016Date of Patent: July 9, 2019Assignee: Theranos IP Company, LLCInventors: Elizabeth A. Holmes, Chinmay Pangarkar, Timothy Smith, Karan Mohan, Samartha Anekal, Daniel Young, James Wasson
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Patent number: 10344258Abstract: A sorting device is provided. The sorting device includes: a carrier substrate; an input unit disposed on the carrier substrate for inputting a biological sample into the sorting device; a porous material disposed on the carrier substrate and adjacent to the input unit, wherein the porous material contains antigen molecules having specificity to a target biological analyte; a driving module generating at least one driving force in the porous material so as to sort the biological sample based on the affinity for the antigen and the driving force; and an output unit disposed on the carrier substrate and adjacent to the porous material for collecting the sorted target biological analyte. A sorting method is also provided.Type: GrantFiled: March 25, 2016Date of Patent: July 9, 2019Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Chih-Chen Chen, Yi-Hsing Hsiao