Patents Examined by Erinne Dabkowski
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Patent number: 9878004Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.Type: GrantFiled: September 25, 2014Date of Patent: January 30, 2018Assignee: Axcella Health Inc.Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
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Patent number: 9827181Abstract: The present disclosure relates to a method and a pharmaceutical composition for hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to an interest.Type: GrantFiled: March 10, 2014Date of Patent: November 28, 2017Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
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Patent number: 9827182Abstract: The present disclosure relates to a method of applying a pharmaceutical composition for promoting hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to an interest.Type: GrantFiled: December 1, 2015Date of Patent: November 28, 2017Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
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Patent number: 9815884Abstract: The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.Type: GrantFiled: March 20, 2015Date of Patent: November 14, 2017Assignee: Cognosci, Inc.Inventors: Michael P. Vitek, Dale J. Christensen
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Patent number: 9815883Abstract: The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis.Type: GrantFiled: April 29, 2015Date of Patent: November 14, 2017Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), UNIVERSITE DE LORRAINEInventors: Sebastien Gibot, Marc Derive
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Patent number: 9809623Abstract: The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of ?4?7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against ?4?1 binding, and have high stability under gastrointestinal conditions.Type: GrantFiled: October 1, 2015Date of Patent: November 7, 2017Assignee: Protagonist Therapeutics, Inc.Inventors: Ashok Bhandari, Dinesh V. Patel, Genet Zemede, Larry C. Mattheakis, David Liu
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Patent number: 9809640Abstract: The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.Type: GrantFiled: October 6, 2015Date of Patent: November 7, 2017Assignee: Cognosci, Inc.Inventors: Michael P. Vitek, Dale J. Christensen
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Patent number: 9701732Abstract: There is provided a fusion protein comprising albumin and retinol-binding protein (RBP), which can be used for preventing or treating fibrotic diseases. The fusion protein, in which albumin and RBP are bound together, is incorporated into stellate cells and induces phenotypic reversion from myofibroblast-like cells to quiescent fat-storing phenotype. Therefore, the fusion protein can be effectively used in preventing or treating fibrotic diseases occurring in the liver, pancreas, lung, or other organs.Type: GrantFiled: January 20, 2016Date of Patent: July 11, 2017Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventor: Jun Seo Oh
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Patent number: 9670265Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.Type: GrantFiled: November 12, 2014Date of Patent: June 6, 2017Assignee: University Health NetworkInventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
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Patent number: 9636299Abstract: Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.Type: GrantFiled: March 15, 2013Date of Patent: May 2, 2017Assignee: XAVIER UNIVERSITY OF LOUISIANAInventor: Partha S. Bhattacharjee
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Patent number: 9624289Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.Type: GrantFiled: November 12, 2014Date of Patent: April 18, 2017Assignee: University Health NetworkInventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
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Patent number: 9617307Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: GrantFiled: June 11, 2015Date of Patent: April 11, 2017Assignees: UNIVERSITE PAUL SABATIER (TOULOUSE III), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
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Patent number: 9610318Abstract: The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on promoting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.Type: GrantFiled: March 25, 2011Date of Patent: April 4, 2017Assignees: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SOOKMYUNG WOMEN'S UNIVERSITY, IL-YANG PHARM CO., LTD., SAMSUNG LIFE PUBLIC WELFARE FOUNDATIONInventors: Dae Ho Cho, Sa Ik Bang, Jeong Min Park, Sun Young Yoon, Sang Yoon Kim, Ha Rum Lee, Yoo Rim Park, Juah Son
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Patent number: 9605025Abstract: Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.Type: GrantFiled: July 6, 2012Date of Patent: March 28, 2017Assignee: Universite de Reims Champagne ArdenneInventors: Stéphane Dedieu, Nicolas Floquet, Laurent Martiny, Christophe Schneider, Albin Jeanne, Emilie Sick, Manuel Dauchez
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Patent number: 9597370Abstract: The present disclosure relates to a method of applying a pharmaceutical composition for promoting hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to a party of interest.Type: GrantFiled: December 1, 2015Date of Patent: March 21, 2017Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
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Patent number: 9586995Abstract: Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.Type: GrantFiled: August 1, 2014Date of Patent: March 7, 2017Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Yumei Feng, Tianxin Yang
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Patent number: 9573976Abstract: Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression of Crw2, or variants thereof, in a host plant or plant cell to increase resistance to an insect pest in a plant such as maize. Methods are also provided for identifying variants of Crw2 that when incorporated into a plant via transgenic or traditional breeding means increase resistance to an insect pest in a plant such as maize. Also provided are methods for increasing resistance by overexpressing Crw1 and Crw2.Type: GrantFiled: September 18, 2013Date of Patent: February 21, 2017Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventor: Yumei Feng
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Patent number: 9572861Abstract: The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.Type: GrantFiled: April 8, 2016Date of Patent: February 21, 2017Assignee: Massachusetts Institute of TechnologyInventors: Ram Sasisekharan, Karthik Viswanathan, Venkataramanan Soundararajan, S. Raguram, Viswanathan Sasisekharan, Vidya Subramanian
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Patent number: 9567367Abstract: Disclosed are peptides and methods for the treatment of bacterial infections and associated inflammation. Effective doses and treatment protocols are disclosed.Type: GrantFiled: January 16, 2013Date of Patent: February 14, 2017Assignee: ATOX BIO LTD.Inventors: Anat Shirvan, Dan Teleman, Gila Arad, Raymond Kaempfer
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Patent number: 9562255Abstract: The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a Mitrecin A polypeptide. The target bacteria can be selected from the group consisting of a Gram-positive bacterium, a Gram-negative bacterium, or both. In one embodiment, the present invention is drawn to a polynucleotide encoding a Mitrecin A polypeptide, a vector comprising the polynucleotide, a host cell comprising the polynucleotide, or a composition comprising the Mitrecin A polypeptide, the polynucleotide, the vector, or the host cell.Type: GrantFiled: August 17, 2015Date of Patent: February 7, 2017Assignee: The MITRE CorporationInventor: Michael Heath Farris