Patents Examined by Erinne Dabkowski
  • Patent number: 9878004
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: January 30, 2018
    Assignee: Axcella Health Inc.
    Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
  • Patent number: 9827181
    Abstract: The present disclosure relates to a method and a pharmaceutical composition for hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to an interest.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: November 28, 2017
    Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
  • Patent number: 9827182
    Abstract: The present disclosure relates to a method of applying a pharmaceutical composition for promoting hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to an interest.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 28, 2017
    Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
  • Patent number: 9815883
    Abstract: The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: November 14, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), UNIVERSITE DE LORRAINE
    Inventors: Sebastien Gibot, Marc Derive
  • Patent number: 9815884
    Abstract: The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: November 14, 2017
    Assignee: Cognosci, Inc.
    Inventors: Michael P. Vitek, Dale J. Christensen
  • Patent number: 9809623
    Abstract: The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of ?4?7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against ?4?1 binding, and have high stability under gastrointestinal conditions.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: November 7, 2017
    Assignee: Protagonist Therapeutics, Inc.
    Inventors: Ashok Bhandari, Dinesh V. Patel, Genet Zemede, Larry C. Mattheakis, David Liu
  • Patent number: 9809640
    Abstract: The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention comprise at least two ApoE mimetic domains and can comprise one or more protein transduction domains. Methods of treating various conditions, such as cancer, inflammatory conditions, and neurodegenerative diseases, by administering the pharmaceutical compositions of the invention are also disclosed.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 7, 2017
    Assignee: Cognosci, Inc.
    Inventors: Michael P. Vitek, Dale J. Christensen
  • Patent number: 9701732
    Abstract: There is provided a fusion protein comprising albumin and retinol-binding protein (RBP), which can be used for preventing or treating fibrotic diseases. The fusion protein, in which albumin and RBP are bound together, is incorporated into stellate cells and induces phenotypic reversion from myofibroblast-like cells to quiescent fat-storing phenotype. Therefore, the fusion protein can be effectively used in preventing or treating fibrotic diseases occurring in the liver, pancreas, lung, or other organs.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: July 11, 2017
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventor: Jun Seo Oh
  • Patent number: 9670265
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9636299
    Abstract: Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 2, 2017
    Assignee: XAVIER UNIVERSITY OF LOUISIANA
    Inventor: Partha S. Bhattacharjee
  • Patent number: 9624289
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 18, 2017
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 9617307
    Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: April 11, 2017
    Assignees: UNIVERSITE PAUL SABATIER (TOULOUSE III), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
  • Patent number: 9610318
    Abstract: The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on promoting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: April 4, 2017
    Assignees: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SOOKMYUNG WOMEN'S UNIVERSITY, IL-YANG PHARM CO., LTD., SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Dae Ho Cho, Sa Ik Bang, Jeong Min Park, Sun Young Yoon, Sang Yoon Kim, Ha Rum Lee, Yoo Rim Park, Juah Son
  • Patent number: 9605025
    Abstract: Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: March 28, 2017
    Assignee: Universite de Reims Champagne Ardenne
    Inventors: St├ęphane Dedieu, Nicolas Floquet, Laurent Martiny, Christophe Schneider, Albin Jeanne, Emilie Sick, Manuel Dauchez
  • Patent number: 9597370
    Abstract: The present disclosure relates to a method of applying a pharmaceutical composition for promoting hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to a party of interest.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 21, 2017
    Assignees: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Shan Chang Chueh, Ching Huai Ko, Nien Tzu Chou, Cheng Ming Chuong, Chih Chiang Chen
  • Patent number: 9586995
    Abstract: Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: March 7, 2017
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Yumei Feng, Tianxin Yang
  • Patent number: 9572861
    Abstract: The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: February 21, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Karthik Viswanathan, Venkataramanan Soundararajan, S. Raguram, Viswanathan Sasisekharan, Vidya Subramanian
  • Patent number: 9573976
    Abstract: Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression of Crw2, or variants thereof, in a host plant or plant cell to increase resistance to an insect pest in a plant such as maize. Methods are also provided for identifying variants of Crw2 that when incorporated into a plant via transgenic or traditional breeding means increase resistance to an insect pest in a plant such as maize. Also provided are methods for increasing resistance by overexpressing Crw1 and Crw2.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: February 21, 2017
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Yumei Feng
  • Patent number: 9567367
    Abstract: Disclosed are peptides and methods for the treatment of bacterial infections and associated inflammation. Effective doses and treatment protocols are disclosed.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: February 14, 2017
    Assignee: ATOX BIO LTD.
    Inventors: Anat Shirvan, Dan Teleman, Gila Arad, Raymond Kaempfer
  • Patent number: 9562255
    Abstract: The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a Mitrecin A polypeptide. The target bacteria can be selected from the group consisting of a Gram-positive bacterium, a Gram-negative bacterium, or both. In one embodiment, the present invention is drawn to a polynucleotide encoding a Mitrecin A polypeptide, a vector comprising the polynucleotide, a host cell comprising the polynucleotide, or a composition comprising the Mitrecin A polypeptide, the polynucleotide, the vector, or the host cell.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: February 7, 2017
    Assignee: The MITRE Corporation
    Inventor: Michael Heath Farris