Patents Examined by Erinne R Dabowski
  • Patent number: 10738080
    Abstract: Provided herein are compounds that inhibit a binding interaction between a ? integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 11, 2020
    Inventor: Xiaoping Du
  • Patent number: 9914753
    Abstract: The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: March 13, 2018
    Assignees: Eastern Virginia Medical School, Children's Health Foundation, Inc., Eriko Life Sciences Ventures, LLC
    Inventors: Neel K. Krishna, Kenji Cunnion