Patents Examined by Ernst V. Arnold
  • Method of treating spinal disk
    Patent number: 10279080
    Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: May 7, 2019
    Assignee: SpineOvations, Inc.
    Inventors: Stuart Young, Neville Alleyne, Nicholas John Manesis
  • Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity
    Patent number: 10272156
    Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: April 30, 2019
    Assignee: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
  • Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine and an alkaline agent, sterilized with heat
    Patent number: 10272181
    Abstract: The object of the present invention is a method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine hydrochloride and an alkaline agent, sterilized with heat, having hyaluronic acid concentration and flow properties, equivalent to those of the corresponding hydrogel based on hyaluronic acid not containing any lidocaine hydrochloride. The present invention also relates to various uses of the aforementioned hydrogel.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: April 30, 2019
    Assignee: ANTEIS S.A.
    Inventor: Samuel Gavard Molliard
  • Natural mosquito larvicide
    Patent number: 10264787
    Abstract: Larvicide and pupicide formulation and methods of administration thereof, harmless for humans and other animals, able to kill all the instars larval stages and pupae in about two hours and fifteen minutes, respectively, with no impact on the environment. Larvicide/pupicide formulation and methods of administration thereof for killing larvae and pupae of Anopheles gambiae and An. stephensi, main vectors of malaria, and Aedes aegypti and Ae. albopictus, main vectors of dengue, Zika virus, chikungunya and yellow fever.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: April 23, 2019
    Assignee: BIOVECBLOK s.r.l.
    Inventors: Claudia Damiani, Aurelio Serrao, Matteo Valzano, Vincenzo Cuteri, Riccardo Arigoni
  • Compositions and methods for treating epithelial cancer
    Patent number: 10265294
    Abstract: The present invention provides the eutomeric isomer of the compound of formula (I), or a salt or solvate thereof, which can be used to treat epithelial cancer in a subject. In certain embodiments, the compound of formula (I) can be used in combination with AICAR and/or cisplatin.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: April 23, 2019
    Assignee: Yale University
    Inventors: Gil G. Mor, Ayesha Alvero
  • Hydrogel formulation comprising oxidative reductive potential water
    Patent number: 10265341
    Abstract: The present invention relates to a hydrogel formulation containing an oxidative reduction potential (ORP) water solution and a gelling agent. The invention further provides a method for treating or preventing a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a hydrogel formulation comprising an oxidative reductive potential solution and a gelling agent. A method for promoting wound healing in a patient is also provided.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 23, 2019
    Assignee: Sonoma Pharmaceuticals, Inc.
    Inventor: Robert Northey
  • N-methyl-N-acylglucamine-containing composition
    Patent number: 10265253
    Abstract: The invention relates to a clear composition which contains at least one anionic surfactant, a betaine surfactant, an N-methyl-N-acylglucamine, a triglyceride oil, a solvent and optionally an additive. The invention also relates to a method for producing the composition. The invention further relates to the use of the composition for the treatment or care of skin or hair, or for use as a shampoo, face cleaner, liquid cleaner or shower gel.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: April 23, 2019
    Assignee: Clariant International Ltd.
    Inventors: Peter Klug, Carina Mildner
  • Dose-dumping resistant controlled release dosage form
    Patent number: 10265308
    Abstract: The present invention provides a simple and improved dosage form that provides a controlled release of methylphenidate contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to methylphenidate. The dosage form exhibits improved resistance to alcohol-related dose dumping.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: April 23, 2019
    Assignee: OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT
    Inventors: Hernan D. Benedetti, Cristian R. Franco, Guido S. Bigatti, Joaquina Faour, Ana C. Pastini
  • Immobilized bioactive hydrogel matrices as surface coatings
    Patent number: 10265436
    Abstract: The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 23, 2019
    Assignee: Pioneer Surgical Technology, Inc.
    Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
  • Product and method for temporary shaping of keratin-containing fibers
    Patent number: 10258558
    Abstract: Cosmetic products and methods for temporarily shaping keratin-containing fibers using the cosmetic products are provided herein. A cosmetic product for temporarily shaping keratinic fibers includes a cosmetic preparation. The cosmetic preparation contains at least one copolymer a1) that is constructed from at least the following monomer units: (meth)acrylic acid, (meth)acrylic acid alkyl ester, and (meth)acrylic acid hydroxy alkyl ester. The cosmetic preparation further contains at least one copolymer a2) that is constructed from at least the following monomer units: styrene, and at least one of acrylic acid or methacrylic acid. The proportion by weight of copolymers a1) and a2) with respect to the total weight of the cosmetic preparation is about 1.0 to about 10 wt %.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: April 16, 2019
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thorsten Knappe, Pamela Kaftan, Maria Catalina Bermudez Agudelo, Tim Bethge
  • Oily cosmetics
    Patent number: 10258545
    Abstract: Oily cosmetics which exhibit sufficient filling properties of viscosity and fluidity during the heating and melting steps of manufacture, significantly ameliorate the problems associated with the aggregation of powder, and have excellent usability characteristics, contain coated powder obtained by subjecting base material powder to composite treatment using at least alkylsilane and phospholipid through a wet method. The oily cosmetics contain 5 to 65 mass % of powder component, 0 to 40 mass % of solid oil, and 25 to 95 mass % of liquid oil, in which the content of the coated powder in the powder component is 0.1 to 65 mass % based on the total amount of the oily cosmetics.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: April 16, 2019
    Assignee: TOKIWA CORPORATION
    Inventors: Shunsuke Togashi, Kazunori Ogino
  • Composition for hair frizz reduction
    Patent number: 10258555
    Abstract: The present invention is directed to a shampoo composition for hair frizz reduction comprising from about 0.1% to about 20% of a moisture control material or mixture of moisture control materials wherein the moisture control material is selected from one or more of the following: wherein R? is —COOY, sulfonic acid, or C?CH—COOY, Y is hydrogen or a metal ion, R1, R2, R3, R4, R5 is hydrogen, methyl, ethyl, propyl, vinyl, allyl, methoxy, ethoxy, hydroxyl, halogen, sulfate, sulfonate, nitro, or —CH?CH—COOR, and wherein the moisture control material is an acidic material and further wherein the moisture control material has a % Protein binding higher than 20 and Molecular Volume lower than 500 and Partition coefficient octanol to water (log P) lower than 3 and hydrogen binding higher than 10 and pKa lower than 5.0.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: April 16, 2019
    Assignee: The Procter and Gamble Company
    Inventors: Supriya Punyani, Brian Xiaoqing Song, Jennifer Mary Marsh, Tiffany Tien-Yun Yang
  • Pharmaceutical compositions of goserelin sustained release microspheres
    Patent number: 10258572
    Abstract: A composition of goserelin sustained release microspheres is provided. The microspheres comprise goserelin, at least one poly (lactide-co-glycolide) and poloxamer or PEG. The sustained release microspheres have comparatively high bioavailability, which promotes the drug taking its full effect and have entrapment efficiency over 90%.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 16, 2019
    Assignee: Shandong Luye Pharmaceutical Co., Ltd.
    Inventors: Wei Sun, Xuemei Zhang, Tao Wang, Guangyi Leng, Kaoxiang Sun, Youxin Li, Wanhui Liu
  • Nanocapsule containing a bioactive compound, and a method of reducing toxicity resulting from cancer therapy
    Patent number: 10251842
    Abstract: Nanocapsules of bioactive compounds derived from natural products as an adjunct treatment for cancer. Nanocapsules of bioactive compounds showed synergy in the treatment of cancer therapy-induced toxicity.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 9, 2019
    Assignee: King Abdulaziz University
    Inventors: Amna Ali Nasser Saddiq, Shaker Ahmad Mousa, Deena Shaker Mousa
  • Method of treating diseases
    Patent number: 10238709
    Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 26, 2019
    Assignee: Chiasma, Inc.
    Inventors: Roni Mamluk, Sam L. Teichman
  • Composite powder in which jade powder particles are impregnated in porous polymer, cosmetic composition containing same and manufacturing method for same
    Patent number: 10238583
    Abstract: The present invention relates to a composite powder of jade powder and a porous polymer, and more specifically relates to a composite powder (jade sphere) in which jade powder particles are impregnated in a porous polymer, the composite powder being produced by spraying, in one step, a dispersion in which jade powder has been dispersed in a solution that dissolves porous polymers, and to a cosmetic composition containing the composite powder, and to a manufacturing method for the composite powder.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: March 26, 2019
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Hyun Suk Lee, Dong-Hyun Paik, Ga Young Cho, Hyoung June Kim, Hae Jin Jung, Dong Hyuk Jang, Yong Jin Kim, Lee Kyoung Kwon, John Hwan Lee, Sung-Wook Choi
  • Agent and method for the temporary deformation of keratin-containing fibers
    Patent number: 10231918
    Abstract: A cosmetic agent for the temporary deformation of keratinous fibers and a method for the temporary deformation of keratinous fibers using the cosmetic agent are provided. The cosmetic agent comprises: a) a cosmetic preparation containing a1) at least one copolymer composed at least of the following monomer units: styrene acrylic acid and/or methacrylic acid; a2) at least one copolymer composed at least of the following monomer units: N-tert-butylacrylamide acrylic acid ethyl acrylate, wherein the weight fraction of copolymers a1) and a2) in the total weight of the cosmetic preparationis about 1.0 to about 10% by weight.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 19, 2019
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thorsten Knappe, Pamela Kaftan, Maria Catalina Bermudez Agudelo, Tim Bethge
  • Enteric soft capsule compositions
    Patent number: 10226432
    Abstract: Described herein are enteric soft capsules comprising gastric resistant polymers and gelatin and methods for manufacturing the same. The enteric soft capsules described herein have enhanced enteric and elastic properties and are simpler to manufacture and produce.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 12, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Helena Maria de Albuquerque Ferreira Teles, Henricus Marinus Gerardus Maria van Duijnhoven, Mélanie Françoise Géraldine Bayarri
  • Method of attenuating reactions to skin irritants
    Patent number: 10226476
    Abstract: The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 12, 2019
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: S. Brian Wilson, Glenn Dranoff, Silke Gillessen
  • Nanosuspension of natural materials and preparation method thereof
    Patent number: 10213382
    Abstract: The present disclosure relates to a method for the preparation of a nanosuspension of at least one natural material, wherein the method comprises the steps of (a) providing at least one natural material having a particle size (D90) of less than 320 ?m; (b) dispersing said at least one natural material of step (a) in a solvent; and (c) milling the dispersion of step (b) to a particle size (D90) of below 1000 nm. The nanosuspension is useful for the preparation of a medicament.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: February 26, 2019
    Assignee: APURANO PHARMACEUTICALS GMBH
    Inventor: Werner Brand