Patents Examined by Evelyn Rabin
  • Detecting and treating heart failure
    Patent number: 5733728
    Abstract: Methods are disclosed for detecting and treating heart failure which are based on the down-regulatory activity of the cytoplasmic RNA-binding polypeptide, AUF1 (A+U-rich element RNA-binding/degradation Factor) toward .beta.-adrenergic receptors. Methods are disclosed for detecting pharmacologicals that inhibit the down-regulatory activity of AUF1 polypeptide for .beta.-adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 gene.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: March 31, 1998
    Assignees: Regents of the University of Colorado, Wake Forest University
    Inventors: J. David Port, Gary Brewer
  • GC1q receptor, HIV-1 gp120 region binding thereto, and related peptides and targeting antibodies
    Patent number: 5728814
    Abstract: Disclosed are immunogens and peptides based on the binding site of gC1q-R for HIV-1 gp120, and immunogens and peptides based on the binding site of HIV-1 gp120 for gC1q-R. The sequence of the gC1q-R binding site for gp120 is shown in SEQ D NO.: 2. The sequence of the HIV-1 gp120 binding site for gC1q-R is shown in SEQ ID NO.: 3. Also disclosed are antibodies and binding molecules to all such immunogens and peptides, and inducing the endogenous production of such antibodies.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: March 17, 1998
    Assignee: Tanox Biosystems, Inc.
    Inventors: Michael S. C. Fung, Bill N. C. Sun, Cecily R. Y. Sun, Young Woo Kim, Liming Yu
  • Expression and export technology of proteins as immunofusins
    Patent number: 5726044
    Abstract: Disclosed are DNAs produced by recombinant techniques for inducing the expression and subsequent secretion of a target protein. The DNAs encode, in their 5' to 3' direction, a secretion cassette, including a signal sequence and an immunoglobulin Fc region, and a target protein. The DNAs can be transfected into a host cell for the expression, production and subsequent secretion of the target protein as a fusion protein. The secreted protein can be collected from the extracellular space, and further purified as desired. The secreted fusion protein additionally can be proteolytically cleaved to release the target protein from the secretion cassette.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: March 10, 1998
    Assignee: Fuji ImmunoPharmaceuticals Corp.
    Inventors: Kin-Ming Lo, Yukio Sudo, Stephen D. Gillies
  • Monoclonal antibody to human glicentin, hybridoma for producing said antibody and assay method for human glicentin using said antibody
    Patent number: 5712105
    Abstract: The present invention describes a monoclonal antibody which recognizes the C-terminal region of human glicentin. The antibody is useful for assaying for the presence of glicentin in a sample.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: January 27, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Noboru Yanaihara, Takeya Sato, Kiyoshi Fukuchi
  • Binding compositions for mammalian T cell antigens and related reagents
    Patent number: 5686257
    Abstract: T cell surface antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: November 11, 1997
    Assignee: Schering Corporation
    Inventors: Jacqueline Kennedy, J. Fernando Bazan, Albert Zlotnik