Patents Examined by Evelyn Y Pyla
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Patent number: 11957719Abstract: The present invention relates to substantially homogenous populations of human retinal progenitor cells having the following positive surface markers: SSEA4, CD73, PTK7 and PSA-NCAM. The invention also relates to method for preparing such substantially homogeneous cell populations from human tissue using cell sorting techniques.Type: GrantFiled: March 19, 2020Date of Patent: April 16, 2024Assignee: The Schepens Eye Research InstituteInventors: Michael J. Young, Petr Y. Baranov
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Patent number: 11944667Abstract: The present invention provides a method of making a wound treatment composition, wherein the method comprises; i) fractionating a whole blood sample into multiple samples including a platelet rich plasma (PRP) sample, a platelet poor plasma (PPP) sample and a erythrocyte sample, wherein the PRP sample has a haematocrit level of 1-10%, ii) processing a portion of the PPP and/or PRP sample to facilitate cleavage of autologous pro-thrombin present in the PPP and/or PRP to produce autologous thrombin, and iii) combining the PRP sample with a portion of the PPP sample and a portion of the thrombin produced in step (ii) to produce the wound treatment composition; wherein step ii) is performed at less than 15° C. In preferred embodiments the PRP has a haematocrit level of 2 or 8%. Wound treatment compositions produced by the methods are also provided as are compositions for use in treating chronic and acute wounds.Type: GrantFiled: March 13, 2020Date of Patent: April 2, 2024Assignee: Biotherapy Services LimitedInventor: Janet Hadfield
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Patent number: 11932874Abstract: The present invention relates to a method of culturing mesenchymal stem cells using gamma-irradiated serum, and more particularly to a method for culturing mesenchymal stem cells, which can improve the adhesion and proliferation rate of stem cells using a medium containing gamma-irradiated serum and an antioxidant. The method for culturing mesenchymal stem cells according to the present invention can restore the adhesion and proliferation rate of stem cells when culturing the stem cells using gamma-irradiated FBS, which is safe from contamination sources but reduces the efficiency of adhesion and proliferation of the cells. Thus, the inventive method is useful for the production of stem cells for cell therapy.Type: GrantFiled: May 24, 2019Date of Patent: March 19, 2024Assignees: R BIO CO., LTD., NATURECELL CO., LTD.Inventors: Jeong Chan Ra, Sung Keun Kang, Eun-Young Kim
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Patent number: 11912924Abstract: The present invention provides a composition for antifreezing including a gold (Au) nanostructure in which at least a portion thereof is concave, thereby it is possible to increase a survival rate of cells due to having excellent effect of inhibiting ice recrystallization when cryopreservation of the cells, and maintain a texture of food even when using in the freezing of food.Type: GrantFiled: December 3, 2019Date of Patent: February 27, 2024Assignee: Korea University Research and Business FoundationInventors: Dong June Ahn, Sang Yup Lee, Yong Ho Cho
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Patent number: 11903975Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.Type: GrantFiled: November 30, 2016Date of Patent: February 20, 2024Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center CorporationInventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
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Patent number: 11903974Abstract: Therapeutic chondrisome compositions and related methods are described.Type: GrantFiled: November 30, 2016Date of Patent: February 20, 2024Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center CorporationInventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
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Patent number: 11898167Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.Type: GrantFiled: October 26, 2020Date of Patent: February 13, 2024Assignees: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of CaliforniaInventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
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Patent number: 11898127Abstract: This disclosure describes methods for growing cells in a controlled environment in a growing room, transporting the cells to a harvest room, and removing the cells from the controlled environment in the harvest room. The disclosed method can limit exposure of cells to contaminants by maintaining a controlled environment through cell growth and additional processing. For instance, the cells may be washed and cooled within the controlled environment. The cells are transferred to a harvest room where they are harvested and removed from the controlled environment.Type: GrantFiled: September 26, 2022Date of Patent: February 13, 2024Assignee: Upside Foods, Inc.Inventors: Matthew Leung, Konrad Müller-Auffermann
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Patent number: 11873508Abstract: There is provided a polymeric microsphere comprising a thermally responsive monomer crosslinked with a functional group monomer, wherein the functional group monomer comprises at least one of a carboxylic acid functional group or an amine functional group. The thermally responsive monomer is preferably N-isopropylacrylamide (NIPAM), and the microspheres preferably comprise a coating of polymerized catecholamines (e.g. DOPA). There is also provided a method of preparing the polymeric microsphere and uses of the polymeric microsphere in culturing, harvesting, or expanding stem cells or stromal cells. Preferably, the cells, e.g. hMSCs (human mesenchymal stem/stromal cells), are expanded or harvested in serum-free and xeno-free medium.Type: GrantFiled: January 22, 2018Date of Patent: January 16, 2024Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jackie Y. Ying, Leng Leng Chng, Daniele Zink, Aysha Farwin
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Patent number: 11873513Abstract: The invention relates to progenitor cells of mesodermal lineage and their use in therapy.Type: GrantFiled: October 7, 2020Date of Patent: January 16, 2024Inventors: Thomas Averell Houze, Martin John Evans, Ajan Trevor Reginald, Ina Laura Pieper
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Patent number: 11833270Abstract: A biological product for clinical xenotransplantation into a human and a method of preparing biological product for clinical xenotransplantation into a human involving producing a non-wild type, biologically engineered swine having a biologically engineered genome such that the swine does not express one or more extracellular surface glycan epitopes, is free of certain pathogens, is reared according to a bioburden-reducing procedure in a closed designated pathogen free herd, wherein the biological product is harvested following the swine being euthanized and the product is aseptically removed from the swine, the biological product is processed involving sterilization and storing the product in a sterile container, and the product does not contain one or more extracellular surface glycans, is free of certain designated pathogens, is biologically active and comprises live cells and tissues capable of vascularizing after xenotransplantation.Type: GrantFiled: June 14, 2021Date of Patent: December 5, 2023Assignee: XENOTHERAPEUTICS, INC.Inventors: Paul W. Holzer, Jon Adkins, Rodney L. Monroy, Elizabeth J. Chang
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Patent number: 11795430Abstract: Disclosed herein is a material that may be useful as a coating for optical slides and medical implants. The material may aid or restrict grown of cells on a coating of the composite material. As such, there is provided a composite material having a substrate on the surface of which a coating layer of an amorphous metal oxide is formed. The metal oxide may be one or more of Ag2O, ZnO, ZrO2, TiO2, CuO, and Y2O3 and the coating layer may be from 5 to 100 nm thick and have a root mean square roughness of the coating surface is from 0.1 to 0.7 nm.Type: GrantFiled: November 10, 2017Date of Patent: October 24, 2023Assignees: National University of Singapore, Agency for Science, Technology, and ResearchInventors: Michal Marcin Dykas, Kingshuk Poddar, Xuefeng Hu, Ee Jen Wilson Wang, Thirumalai Venky Venkatesan, Abhijeet Patra, Viknish Krishnan Kutty, Paul Lorenz Bigliardi, Mei Bigliardi
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Patent number: 11739295Abstract: The invention discloses the method of differentiating human induced Pluripotent Stem cells (iPS cells) to obtain pigmented cells which produce melanin. The protocol described is much more efficient than any other method used to obtain melanin in vitro.Type: GrantFiled: September 21, 2018Date of Patent: August 29, 2023Assignee: UNIWERSYTET JAGIELLONSKIInventors: Marcin Majka, Maciej Sułkowski
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Patent number: 11739291Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.Type: GrantFiled: April 25, 2018Date of Patent: August 29, 2023Assignee: Purdue Research FoundationInventors: Sherry L. Voytik-Harbin, Stacey L. Halum, Sarah Brookes, Hongji Zhang
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Patent number: 11737451Abstract: A system and method are provided for wet storage of tissue. In an embodiment, a solution for the wet preservation of tissue may include between about 0.1% to about 50% by volume dimethyl sulfoxide (DMSO) and one or more soluble monovalent or divalent metal cationic salts. A wet-preserved tissue and method for preparing the wet-preserved tissue for ultimate use, is also provided.Type: GrantFiled: June 10, 2020Date of Patent: August 29, 2023Assignee: Axogen CorporationInventor: Mindy E. Sadik
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Patent number: 11713445Abstract: The present disclosure provides a method of fabricating curvature-defined (C-D) or shape-defined (S-D) concave and convex polydimethylsiloxane (PDMS) surfaces and a method of fabricating C-D or S-D convex and concave gel surfaces for use in cell and tissue culturing and in other surface and interface applications, and provides a method of using C-D or S-D convex and concave surfaces with varying curvatures to direct cell attachment, spreading, and migration.Type: GrantFiled: December 13, 2019Date of Patent: August 1, 2023Inventor: Shengyuan Yang
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Patent number: 11713446Abstract: The present invention provides improved and/or shortened processes and methods for reprogramming TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy. Such reprogrammed TILs find use in therapeutic treatment regimens.Type: GrantFiled: May 4, 2022Date of Patent: August 1, 2023Assignee: IOVANCE BIOTHERAPEUTICS, INC.Inventors: Cecile Chartier-Courtaud, Krit Ritthipichai
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Patent number: 11702634Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.Type: GrantFiled: April 2, 2018Date of Patent: July 18, 2023Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Domicinda M. Hill, Mark E. Jones
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Patent number: 11697893Abstract: The present invention relates to a method for producing biodegradable fibers on the basis of a silane compound, said silane compound being crosslinked during production and, at least to some extent, an organic acid being incorporated into the forming crosslinked structure via covalent bonds and/or contributing to the crosslinking. The present invention also relates to the fibers that can be produced by the method according to the invention and to the use thereof.Type: GrantFiled: September 26, 2018Date of Patent: July 11, 2023Assignee: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.Inventors: Miranda Rothenburger-Glaubitt, Bastian Christ, Walther Glaubitt, Jörn Probst
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Patent number: 11680904Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.Type: GrantFiled: May 2, 2017Date of Patent: June 20, 2023Assignee: The George Washington UniversityInventors: Emilia Entcheva, Aleksandra Klimas