Patents Examined by F. Bernhardt
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Patent number: 4981989Abstract: Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from one or more of: (a) C.sub.1 -C.sub.24 branched or straight chain alkyl; (b) C.sub.1 -C.sub.24 branched or straight chain alkoxy; (c) ##STR2## wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, C.sub.1 -C.sub.20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.Type: GrantFiled: November 8, 1989Date of Patent: January 1, 1991Assignee: American Cyanamid CompanyInventors: Allan Wissner, Phaik E. Sum, Robert E. Schaub
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Patent number: 4965264Abstract: A thienocinnoline compound of the general formula ##STR1## wherein R stands for hydrogen, a halogen or a lower alkyl, Ar stands for an aryl, a heteroaryl, or an aryl or a heteroaryl having as a substituent at least a halogen, a lower alkyl, a lower alkoxy, nitro, amino, hydroxy, trifluoromethyl and/or a lower alkanoylamino; and the bond between 5a-position and 6-position represents a single bond or a double bond, which is useful as an antianxiety agent, amnesia-treating drug, a brain function-activating drug, an antidementiac drug or a potentiating agent of biological protection.Type: GrantFiled: November 18, 1988Date of Patent: October 23, 1990Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Toru Nakao, Kenji Morita, Masao Hisadome, Shuzo Takehara
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Patent number: 4943634Abstract: N-Aryl benzaimides wherein the aryl group is a nitrogen containing heterocycle are useful as selective herbicidal agents. Compositions containing the novel benzamides and a herbicidal method of selective weed control are disclosed.Type: GrantFiled: November 14, 1988Date of Patent: July 24, 1990Assignee: Eli Lilly and CompanyInventor: Kenneth W. Burow, Jr.
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Patent number: 4943584Abstract: Novel (p-phenoxyphenoxy)-methyl-five-membered heeroaromatic radicals of the formula ##STR1## where the substituents have the following meanings: R.sup.1, R.sup.2, R.sup.3 hydrogen, halogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.3 -C.sub.10 -cycloalkyl, nitro or cyano,R.sup.4 hydrogen or C.sub.1 -C.sub.4 -alkyl, and a five-membered heteroaromatic ring, and their use for combating pests.Type: GrantFiled: April 20, 1988Date of Patent: July 24, 1990Assignee: BASF AktiengesellschaftInventors: Hans Theobald, Christoph Kuenast, Peter Hofmeister, Hans-Juergen Neubauer, Thomas Kuekenhoehner, Wolfgang Krieg, Joachim Leyendecker, Uwe Kardorff
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Patent number: 4939126Abstract: 1-Pyrrolidineacetamide derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen atom or a trialkylsilyl group, R.sub.2 and R.sub.3 are hydrogen atom, respectively, when R.sub.1 is hydrogen atom, R.sub.4 is an alkyl group, R.sub.5 is a radical of ##STR2## in which R.sub.6 and R.sub.7 are an alkyl group, respectively, m and n are an integer of 1 to 3, respectively,or R.sub.4 represents together with R.sub.5 a hetero cyclic ring having nitrogen and silicon atoms or piperazine ring having a substituent of ##STR3## in which R.sub.6 and n have the meanings as referred to, and R.sub.2 and R.sub.4 as well as R.sub.3 and R.sub.5 form a hetero cyclic ring, respectively, connected with an alkylene chain, where R.sub.1 is the trialkylsilyl group, salts thereof, a process for the preparation thereof, as well as use thereof as for a medicine.Type: GrantFiled: July 11, 1988Date of Patent: July 3, 1990Assignee: Sanwa Kagaku Kenkyusho Co. Ltd.Inventors: Masayasu Kurono, Tsunemasa Suzuki, Tomoo Suzuki, Kiyotaka Hirooka, Yukiharu Matsumoto, Hiroshi Ozawa, Kiichi Sawai
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Patent number: 4935434Abstract: Disclosed herein are isoxazole-4-carboxamides having the formula ##STR1## wherein R.sup.1 is C.sub.3-6 cycloalkyl and R.sup.2 is selected from the group consisting of C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkynyl, C.sub.3-6 cycloalkyl, phenyl, and phenyl substituted with at least one group selected from C.sub.1-5 alkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, and halo-substituted C.sub.1-5 alkyl; with the proviso that when R.sup.1 is cyclopropyl, R.sup.2 is not methyl, ethyl, or cyclobutyl; or R.sup.1 is C.sub.1-5 alkyl and R.sup.2 is phenylmethyl wherein the ring portion is opt. substituted with a halo-substituted C.sub.1-5 alkyl group. These compounds have antiinflammatory and antiarthritic activities and are also useful as intermediates in the preparation of .beta.-ketonitriles.Type: GrantFiled: January 26, 1988Date of Patent: June 19, 1990Assignee: Bristol-Myers CompanyInventor: William T. Han
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Patent number: 4925941Abstract: A quinoxaline is oxidized by means of hydrogen peroxide in an inert solvent medium in the presence of water and of a catalyst selected from selenium and selenium compounds.The process applies to the preparation of substituted and unsubstituted 2,3-dihydroxyquinoxalines.Type: GrantFiled: March 4, 1988Date of Patent: May 15, 1990Assignee: Interox (Societe Anonyme)Inventors: Paul Deschrijver, Jean-Pierre Ganhy
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Patent number: 4900354Abstract: Compounds of the class comprising (quinolinyl and quinoxalinyloxy)phenoxy) alkenols, e.g., 4-(4-((6-chloro-2-quinolinyl)oxy)phenoxy)-2-penten-1-ol; and a method of preparation, comprising reacting an appropriately substituted quinoline or quinoxaline, e.g., 2,6-dichloroquinoline, with a phenolic substituted pentenol, e.g., 4-(4-hydroxyphenoxy)-2-penten-1-ol, in the presence of a base and organic solvent under an inert atmosphere with or without heat, and then recovering the product.These compounds are useful as intermediates for preparing various known herbicidal compounds and are useful in their own right as post-emergent herbicides for controlling grassy weeds in the presence of corn plants.Type: GrantFiled: August 29, 1986Date of Patent: February 13, 1990Assignee: The Dow Chemical CompanyInventors: James A. Turner, Paul S. Zorner, Wendy S. Jacks
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Patent number: 4889551Abstract: Novel 3-substituted phenyl-2-isoxazoline-5-carboxylic acids or esters thereof. These compounds have excellent properties as plant growth regulators.Type: GrantFiled: September 2, 1987Date of Patent: December 26, 1989Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Kengo Oda, Tsutomu Ishii, Yukiharu Fukushi, Yuji Enomoto, Makoto Nishida, Yoshikata Hojo
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Patent number: 4885023Abstract: As a herbicide, a 9-phenylimino-8-thia-1,6-diazabicyclo [4.3.0]nonane-7-one derivative having the formula: ##STR1## wherein each of X and Y is hydrogen or halogen, and Z is ##STR2## wherein R.sup.1 is alkyl or cycloalkyl, or --COOR.sup.2 wherein R.sup.2 is alkyl.Type: GrantFiled: December 22, 1987Date of Patent: December 5, 1989Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Mikio Yamaguchi, Yukihiro Watase, Takeshi Kambe, Susumu Katou
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Patent number: 4820716Abstract: 7-(1-Pyrrolidinyl)-3-quinolonecarboxylic acid derivatives of the formula ##STR1## in which A is CH, CCl, CF or N,R.sup.1 is hydroxyl, hydroxymethyl or mercapto andR.sup.2 is hydrogen, alkyl, having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,with the proviso that, when R.sup.1 is hydroxy, A is not CF or N, or pharmaceutically acceptable hydrates, or salts thereof, are useful as antibacterials and animal feed utilization promoters.Type: GrantFiled: February 12, 1987Date of Patent: April 11, 1989Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Klaus Grohe, Hans-Joachim Zeiler, Karl G. Metzger
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Patent number: 4810789Abstract: A process for conversion of one polymorphic crystalline form of buspirone into its other polymorphic crystalline form.Type: GrantFiled: August 28, 1987Date of Patent: March 7, 1989Assignee: Bristol-Myers CompanyInventors: Robert J. Behme, Terry T. Kensler, Douglas G. Mikolasek
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Patent number: 4803217Abstract: Hapalindolinone compounds are produced by the controlled aerobic fermentation of a cyanobacterium of the genus Fischerella, ATCC No. 53558.Type: GrantFiled: December 24, 1986Date of Patent: February 7, 1989Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Charles F. Hirsch, Janet M. Sigmund, Douglas J. Pettibone
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Patent number: 4800223Abstract: A quinoxalinone derivative of the following formula: ##STR1## where R.sub.1 and R.sub.2 are each methyl, ethyl or propyl; and R.sub.3 is a chlorine atom or azide, is a reagent capable of high-sensitivity labelling for fluorescence that reacts quantitatively with each of primary, secondary and tertiary hydroxyl groups to provide for easy labelling for fluorescence and which allows quantitative analyzing over a wide detection range.Type: GrantFiled: March 11, 1987Date of Patent: January 24, 1989Assignee: Tosoh CorporationInventor: Yosuke Ohkura
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Patent number: 4788188Abstract: The present invention relates to new quinolylglycinamide derivatives corresponding to the following general formula: ##STR1## The invention also relates to a process for preparing these compounds and their therapeutic application as a psychotropic agent.Type: GrantFiled: May 6, 1986Date of Patent: November 29, 1988Assignee: Sanofi (S.A.)Inventors: Jean-Claude Vernieres, Etienne Mendes, Michel Morre, Peter Keane, Jacques Simiand
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Patent number: 4788198Abstract: Compounds of the formula ##STR1## R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or NHCOCOOR.sub.1 ;R.sub.3 is hydrogen or NHCOCOOR.sub.1 ;A is ##STR2## R.sub.4 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)-amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; andR.sub.5 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or NHCOCOOR.sub.1 ;and, when R.sub.1 is hydrogen, nontoxic, pharmaceutically acceptable salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders such as asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.Type: GrantFiled: April 27, 1987Date of Patent: November 29, 1988Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Karl G. Grozinger, James T. Oliver