Patents Examined by F. Christopher Eisenchenk
  • Monoclonal antibodies to human plasma prekallikrein
    Patent number: 5444156
    Abstract: Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein, specifically the heavy chain thereof, and kallikrein-Cl-inhibitor complex; at least one of these three antibodies recognizes kallikrein-alpha.sub.2 -macroglobulin complex and kallikrein-antithrombin III complex. The antibodies do not cross-react with tissue kallikrein. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with SP2/O-Agl4 myeloma cells. Diagnostic and biochemical uses of the monoclonal antibodies are provided.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: August 22, 1995
    Assignee: Temple University-of The Commonwealth System of Higher Education
    Inventors: Dulce C. Veloso, Robert W. Colman
  • Extracellular segments of human .epsilon. immunoglobulin anchoring peptides and antibodies specific therefor
    Patent number: 5342924
    Abstract: Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. Three different isoforms of the C-terminal segment of the human .epsilon. chain resulting from alternative mRNA splicings in the membrane exon region are disclosed, one of which is secreted and not membrane-bound.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: August 30, 1994
    Assignee: Tanox Biosystems, Inc.
    Inventor: Tse W. Chang