Abstract: Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head and methods and systems for conducting a scanned optically transduced assay where the scanning includes at least one first relative angular motion and at least one second angular motion or at least one linear motion. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.

Abstract: An encoder spectrograph is used to analyze radiation from one or more samples in various configurations. The radiation is analyzed by spatially modulating the radiation after it has been dispersed by wavelength or imaged along a line. Dual encoder spectrographs may be used to encode radiation using a single modulator. An encoder spectrograph includes a modulator with radiation filters having non-equal widths and centered at non-equal intervals along the encoding axis of the modulator.

Abstract: A fiber optical sensor includes a light source, a detector and an optical resonator having a multimode optical fiber and two reflective layers respectively provided adjacent to or on ends of the optical fiber. Excitation light from the light source is coupled into the optical resonator through a transparent hole formed in one of the reflective layers. An evanescent wave extends outside the optical fiber in the active region of the optical fiber. The fluorescent light generated by a fluorescent material excited by the evanescent wave in response to the presence or concentration of the analyte in a sample to be assayed is detected by the detector. The light beam is reflected back and forth between the first and second reflective layers many times within the optical resonator whereby the strength of the fluorescent light is significantly increased thereby resulting in a significantly signal amplification.

Abstract: An encoder spectrograph is used to analyze radiation from one or more samples in various configurations. The radiation is analyzed by spatially modulating the radiation after it has been dispersed by wavelength or imaged along a line. Dual encoder spectrographs may be used to encode radiation using a single modulator. An encoded photometric infrared spectroscopy (“EPIR”) analyzer employs orthogonal encoded components having substantially identical modulation frequencies, which may allow for the multiplexing of up to twice as many encoded components.

Abstract: A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Abstract: The disclosure relates to method and apparatus for obtaining a multimodal hyperspectral image of a sample for widefield spectral analysis. An apparatus according to one embodiment may include a plurality of optical lenses configured to interchangeably receive photons and focus the photons; a plurality of tunable filters positioned in a filter housing, each tunable filter selectively receiving the focused dispersed photons from one of the plurality of optical lenses, each tunable filter providing wavelength-selective filtered photons; a first optical camera and a second optical cameras for selectively receiving the wavelength-selective filtered photons from each of the plurality of tunable filters and combining said filtered photons to form a hyperspectral spatially accurate, wavelength-resolved image of the sample.

Abstract: This invention discloses a spectroscopic sensor that is integrated with a mobile communication device, such as a mobile phone. The spectroscopic sensor is capable of measuring the optical spectra of a physical object for purposes of detection, identification, authentication, and real time monitoring. Through the mobile communication device, the obtained spectral information can be transmitted, distributed, collected, and shared by utilizing all the functions of the known or existing wireless communication networks.

Abstract: An integrated circuit includes a photosensor array with subrange cells that photosense within respective subranges of an energy range. An optical signal and the array move relative to each other, and, for segments of their relative movement, sets of subrange cells photosense within subranges that are different. For example, a scanning device can cause relative scanning movement. The optical signal can be produced by illuminating a two-dimensional object. The photosensed quantities for a part of the optical signal can be used to produce spectral information for the part.

Abstract: Methods for directly comparing the light spectral power distribution of a natural light source to the light spectral power distribution received on the target area of an outdoor accelerated weathering device, comparing the spectral measuring assembly on accelerated weathering devices with traceable spectral measuring assemblies measuring the same light source at the same instant in time, comparing different outdoor accelerated weathering devices to one another with respect to continuous direct measurement of each such device in a collection relating the quality of each single device back to a single standard measured by all devices and rationalizing the results of different methods of weatherability testing.

Abstract: An apparatus and method for monitoring diabetes through breath acetone detection and quantitation employs a microplasma source in combination with a spectrometer. The microplasma source provides sufficient energy to produce excited acetone fragments from the breath gas that emit light. The emitted light is sent to the spectrometer, which generates an emission spectrum that is used to detect and quantify acetone in the breath gas.

Abstract: A method for remotely detecting whether a subject is alive, comprising the steps of determining a calibration spectral signature for light reflectance from living skin, normalizing the calibration spectral signature values to the calibration reflectance value at a reference wavelength, storing the normalized calibration spectral signature, determining a subject spectral signature of the light reflectance of a region of skin of the subject whose liveness is to be determined, normalizing the subject spectral signature values to the subject reflectance value at the reference wavelength, comparing the normalized subject spectral signature with the normalized calibration spectral signature for at least one wavelength, generating a subject liveness signal based on the comparison of the normalized subject spectral signature with the normalized calibration spectral signature, and emitting the subject liveness signal.

Abstract: An apparatus for normalizing a PCR instrument, can comprise a microplate comprising at least 6,000 wells and a system of dyes at known concentrations in a plurality of the at least 6,000 wells. A method for normalizing a system can comprise (a) providing a microplate comprising at least 6,000 wells and a system of dyes; (b) exciting at least one dye; (c) detecting an emission output for the at least one dye; (d) determining if the emission output is in an acceptable range; and (e) adjusting the system so that the emission output is in the acceptable range.

Abstract: A portable high speed, low cost, wide spectrum light scanning unit with an aiming device for receiving reflected light from an object and diffracting the light into segments of wavelengths and a linear sensor array having elements positioned to receive the segments and to measure the relative magnitude of such segments to define a spectral distribution of the object for transmission to a remote site for identification and/or analysis without augmentation. In addition, the specification discloses the use of a micro-controller to process the distribution and to identify and/or analyze the object.

Abstract: An apparatus and method are provided to verify the composition of a medical fluid in a fluid container. The verification is performed at a centralized location, where light is transmitted through the fluid and detected by a sensor that generates signals representative of the spectral data of the actual composition of the fluid. These signals are compared with the spectral data of an expected composition of the fluid. Based on the comparison, a label is generated that identifies the composition of the fluid and is affixed to the fluid container. The fluid container, with the verified fluid, is distributed to the point of care.

Abstract: A wide field catadioptric imaging spectrometer with an immersive diffraction grating that compensates optical distortions. The catadioptric design has zero Petzval field curvature. The imaging spectrometer comprises an entrance slit for transmitting light, a system with a catadioptric lens and a dioptric lens for receiving the light and directing the light, an immersion grating, and a detector array. The entrance slit, the system for receiving the light, the immersion grating, and the detector array are positioned wherein the entrance slit transmits light to the system for receiving the light and the system for receiving the light directs the light to the immersion grating and the immersion grating receives the light and directs the light through the system for receiving the light to the detector array.

Abstract: An online method and system for evaluating a gemstone is provided that enables a consumer to use a personal computer to evaluate the visual appearance and measurement data of the gemstone by emulating the laboratory instruments that previously collected the data for the gemstone. The computer is connected to the internet and a website that is linked to a gemstone database, emulation software and graphical user interface. The consumer identifies the specific gemstone he or she wants to evaluate, and an interactive gemstone certificate screen is displayed. The consumer separately selects and then emulates a variety of lab instruments, such as color and clarity grading, geometric measuring, and light performance and light ray tracing instruments. Graphical images and data pertaining to the selected gemstone are displayed on the computer monitor, and selected portions of the database are downloaded and saved on the computer memory.

Abstract: An apparatus and method for calibrating range measurements are provided wherein calibration data is collected with each range measurement or group of range measurements. The calibration data comprise a plurality of simulated range measurements. In one embodiment, the simulated range measurements are used to analyze errors that vary with time and environmental conditions. Range measurements are calibrated by correlating a measured flight time of a transmitted and reflected laser beam with the simulated range measurements and a relationship between laser beam flight times and target ranges based on the speed of the laser beam.

Abstract: A medium is analyzed for the search for an odorous biological molecule characteristic of a specific substance in an environment to be studied comprising the steps of: exposing a component containing at least one olfactory biological receptor, capable of selectively attaching the type of odorous molecule sought, to an atmosphere taken from the environment to be studied; irradiating that component by means of an incident laser radiation having a wavelength chosen in the ultraviolet close to the absorption wavelength for the olfactory receptor, to cause the excitation of a resonance Raman scattering in the irradiated component; and analyzing the Raman spectrum obtained to determine whether or not it corresponds to the Raman spectrum of the olfactory receptor having attached an odorous molecule of the type sought in the atmosphere sampled, so as to identify any presence of the specific substance mentioned in the environment to be studied.

Abstract: A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

Abstract: The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.