Abstract: A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).

Abstract: A radiation imaging apparatus includes a radiation detection unit including a plurality of sensors which detect radiation, and a monitoring unit which monitors irradiation of radiation based on signals detected by the plurality of sensors. The monitoring unit determines a plurality of effective sensor candidates from the plurality of sensors, and determines effective sensor(s) from effective sensor candidates excluding certain effective sensor candidates of the plurality of effective sensor candidates, the certain effective sensor candidates being an effective sensor candidate which has detected a signal having a maximum value and an effective sensor candidate which has detected a signal having a minimum value. The monitoring unit monitors irradiation of radiation based on signal(s) detected by the effective sensor(s).

Abstract: A UV illumination method includes moving a UV peripheral separate from a smart device to location associated with a plurality of target surfaces, selecting a UV illumination application executing upon the smart device, selecting an icon from within the UV illumination application, sending via a wireless communication mechanism of the smart device to the UV peripheral, instructions to turn on a UV light disposed in the UV peripheral in response to the selection of the icon, receiving via a wireless communication mechanism disposed in the UV peripheral, the instructions to turn on the UV light, illuminating, with the UV light within the UV peripheral, sanitizing UV light to the plurality of target surfaces other than surfaces of the smart device in response to the instructions, and thereafter terminating illuminating, with the UV light within the UV peripheral, the sanitizing UV light from the plurality of target surfaces.

Abstract: Techniques for controlling an optical system include accessing a measured value of a property of a particular pulse of a pulsed light beam emitted from the optical system, the property being related to an amount of coherence of the light beam; comparing the measured value of the property of the light beam to a target value of the property; determining whether to generate a control signal based on the comparison; and if a control signal is generated based on the comparison, adjusting the amount of coherence in the light beam by modifying an aspect of the optical system based on the control signal to reduce an amount of coherence of a pulse that is subsequent to the particular pulse.

Abstract: A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette.

Abstract: An example apparatus includes an outer housing and a drive shaft at least partially within and rotationally independent from the outer housing. A drill bit may be coupled to the drive shaft. At least one gamma ray sensor may be rotationally coupled to the drive shaft within the outer housing. In certain embodiments, the apparatus further includes a housing rotationally coupled to the drive shaft, wherein the housing comprises at least one pressurized cavity; and the at least one gamma ray sensor is located within the at least one pressurized cavity.

Abstract: An in-toilet apparatus for discrimination of urine and feces is disclosed. An optical sensor is provided for the analysis of urination and defecation events within a toilet bowl. Additionally, strain gauges are provided to make possible the quantification of urine and feces that a user releases. The combination of data from the optical sensors and strain gauges makes it possible for a user to readily know the mass of their bodily excrements, characterized by excrement type. In several embodiments the optical sensor is a thermal camera mounted on the toilet seat or in the toilet bowl. In other embodiments the optical sensor is a water level sensor. In varying embodiments, strain gauges are located in the toilet seat or in an attached footscale or both.

Abstract: A method and apparatus is disclosed for differentially altering the radiation response across multiple MOSCAP sensors by placing different thin gate materials with different atomic numbers on a series of MOS-based radiation sensors. The secondary electrons created in high-atomic weight materials (such as gold) at lower incident photon energy levels enable a tissue equivalent radiation response and radiations source identification/differentiation. This is a desirable alternative to using filters with different coefficients across a series of MOSCAP radiation sensor which will attenuate the signal and degrade the device form factor. The method and apparatus disclosed achieves the same functionality but with inherent gain instead of attenuation, thus increasing sensitivity. This will improve the minimum resolvable dose for x-rays and low-energy gammas (high-energy gammas will remain the same), and produces a response that can distinguish the energy level of incident radiation photon.

Abstract: Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging includes a mobile brain imager configured to obtain positron emission tomography (PET) scans of a subject in motion, and a virtual reality (VR) system configured to provide one or more stimuli to the subject during the PET scans. In another example, a method for virtual ambulatory environment brain imaging includes providing stimulation to a subject through a virtual reality (VR) system; and obtaining a positron emission tomography (PET) scan of the subject while moving in response to the stimulation from the VR system. The mobile brain imager can be positioned on the subject with an array of imaging photodetector modules distributed about the head of the subject.

Abstract: A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be.

Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light to particles of a sample fluid flowing in the detection cavity. The photo-responsive material faces the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to a longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.

Abstract: Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted along with photoluminescence spectroscopy (i.e. fluorescence and/or phosphorescence spectroscopy) to provide high levels of sensitivity and specificity in the same instrument.

Abstract: A radiation imaging apparatus includes a pixel array having a plurality of pixels configured to detect radiation, a detector configured to detect radiation irradiation, and a controller. In a case in which a measured value obtained by using the detector exceeds a threshold in one range out of a positive range and a negative range with respect to a reference value, the controller controls a radiation image capturing operation by determining that the radiation irradiation has started. The controller changes the threshold in accordance with the measured value of the other range out of the positive range and the negative range.

Abstract: The invention relates to medical imaging and, more specifically, to intraoral dental radiology. The sensor according to the invention includes a series (SPHx) of detection photodiodes for detecting the arrival of an X-ray flash. The series of photodiodes occupies the location of a central column of the matrix of pixels. The signal of the missing pixel in each row can be reconstructed by interpolating the signals provided by the adjacent pixels of the row. The detection photodiodes are identical to the photodiodes of the active CMOS pixels. They are all electrically connected on one side to a reference potential and on the other side to a detection conductor (CD) extending along the series of photodiodes. This detection conductor is connected to a detection circuit (DX) delivering a signal for triggering the capture of an image when the detected current or the variation in this current exceeds a threshold showing that an X-ray flash has been initiated.

Abstract: Naphthalene, benzene, toluene, xylene, and other volatile organic compounds VOCs have been identified as serious health hazards. Embodiments of the invention are directed to methods and apparatus for near-real-time in-situ detection and accumulated dose measurement of exposure to naphthalene vapor and other hazardous gaseous VOCs. The methods and apparatus employ excitation of fluorophors native or endogenous to compounds of interest using light sources emitting in the ultraviolet below 300 nm and measurement of native fluorescence emissions in distinct wavebands above the excitation wavelength. The apparatus of some embodiments are cell-phone-sized sensor/dosimeter “badges” to be worn by personnel potentially exposed to hazardous VOCs. The badge sensor of some embodiments provides both real time detection and data logging of exposure to naphthalene or other VOCs of interest from which both instantaneous and accumulated dose can be determined.

Abstract: We disclose a chemical sensing device for detecting a fluid. The sensing device comprises: at least one substrate region comprising at least one etched portion; a dielectric region formed on the at least one substrate region, the dielectric region comprising at least one dielectric membrane region adjacent to the at least one etched portion; an optical source for emitting an infra-red (IR) signal; an optical detector for detecting the IR signal emitted from the optical source; one or more further substrates formed on or under the dielectric region, said one or more further substrates defining an optical path for the IR signal to propagate from the optical source to the optical detector. At least one of the optical source and optical detector is formed in or on the dielectric membrane region.

Abstract: The dissolved gas sensor system includes a dissolved gas sensor partially located within a housing and partially extending through the housing lid. The sensor is created by affixing a selectively permeable membrane to a dissolved gas transducer with a waterproof polymer. This forms a membrane cavity between the membrane, polymer, and transducer. The membrane cavity allows the transducer to detect whatever gas or gases can pass through the selectively permeable membrane. These readings pass to a controller located within the housing body that can receive and process data, and store the data in a removable data storage for later retrieval by a user. The controller can also regulate overall power consumption of the system to increase the operating life of the system.

Abstract: An imaging apparatus includes a plurality of pixels arranged in a matrix form, each pixel being configured to generate an electric signal, and each being configured such that the electric signal can be read out nondestructively, an output amplifier configured to sequentially output electric signals read out nondestructively from the plurality of pixels, and a control unit configured to, in a period when electric signals for one frame of image data are being read out nondestructively from the plurality of pixels, execute nondestructive readout processing a plurality of times for reading out electric signals nondestructively from pixels in a first row, and execute nondestructive readout processing a plurality of times for reading out electric signals nondestructively from pixels in a second row adjacent to the first row. In this case, the control unit resets the output amplifier in a period when the nondestructive readout processing is performed a plurality of times on the pixels of the first row.

Abstract: A time label combination method, comprising the steps: collecting data acquisition system digital measurement values and establishing a database for the measured values; identifying atomic time label quantities and shape fluctuation statistics; estimating a covariance matrix of each atomic time label; according to the least squares criterion, giving the time label combination. Also provided is a time label combination system, comprising a low-dose pre-acquisition data module, a digital identification module, a quantitative variance calculation module, and a time label combination parameter calculation module. By means of using the described time label combination method and system, system and resolution is effective increased, and the invention is particularly suitable for nuclear instrument time acquisition.

Abstract: A method is provided for evaluating a procedure for determining an aggregate radiotherapy dose received in the course of a radiotherapy treatment. The method includes: defining a deformable model of at least one organ to be treated and of at least one neighboring organ, generating a series of simulated images, interpretable by the procedure to be evaluated, with aid of the model; comparing the aggregate dose calculated by the procedure to be evaluated, applied to at least one of the simulated images, with a reference aggregate dose, so as to deliver at least one item of information representative of the quality of the procedure, the reference aggregate dose being obtained by taking into account anatomical deformations applied to the organs, so as to determine a reference dose actually received at each treatment session by the organs, as a function of their actual shape and/or actual position during this session.