Patent number: 6326500
Abstract: Compounds of formula (I)
and salts thereof, wherein
R1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, —NR13R14, —N(R15)SO2R16, haloalkoxy, haloalkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, —SOnR7, alkoxycarbonylalkyl, carboxylalkyl, —CONR11R12, carbamoylvinyl, —O—SO2R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl, —NR60R61 or —(O)z—L3—G (G=−NR22R23, —SOmR26, CONR27R28 or —OR29);
R2 and R3 are independently hydrogen halo, alkyl, alkoxy, —NR13R14, haloalkoxy, haloalkyl, hydroxy, —SOnR7 or —NR60R61;
L1 is a bond, alkylene, cycloalkylene or cycloalkylidene;
T is a bond, O, S, SO, SO2, CO or 1,3-dioxolan-2-ylidene;
L2 is alkylene, cycloalkylene or cycloalkylidene;
R6 is hydrogen or alkyl;
Q is alkylene; and
Y is imidazolyl,
which are antiinflammatory, antiallergic and immunodulant agents.
Type:
Grant
Filed:
December 27, 2000
Date of Patent:
December 4, 2001
Assignee:
Abbott Laboratories
Inventors:
David John Calderwood, Adrian John Fisher, James Edward Jeffery, Colin Gerhart Pryce Jones, Paul Rafferty
Patent number: 6313311
Abstract: Imidazole derivatives of formula (I)
wherein n is 0 or 1, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen or R2 and R3 together form a double bond, R3 is hydrogen or C1-C4-alkyl or R2 and R3 together form a double bond, R4 is hydrogen, C1-C4-alkyl, hydroxy or C1-C4-alkoxy, R5 is hydrogen or C1-C4-alkyl or R4 and R5 together with the carbon atom to which they are attached form a carbonyl group, R6, R7 and R8 are each the same or different and are independently hydrogen, C1-C4-alkyl or C2-C4-alkenyl, C3-C7-cycloalkyl, hydroxy, C1-C4-alkoxy, C1-C4-hydroxyalkyl, thiol, C1-4-alkylthio, C1-4-alkylthiol, halogen, trifluoromethyl, nitro or optionally substituted amino, X is —CHR9—(CHR10)m—, m is 0 or 1, and R9 and R10 are each the same or different and are independently hydrogen or C1-C4-alkyl; or a pharmaceutically acceptable ester or salt thereof, their preparation, use and pharmaceutical compositions comprising them are described.
Type:
Grant
Filed:
February 2, 1999
Date of Patent:
November 6, 2001
Assignee:
Orion Corporation
Inventors:
Arto Karjalainen, Paavo Huhtala, Juha-Matti Savola, Siegfried Wurster, Maire Eloranta, Maarit Hillilä, Raimo Saxlund, Victor Cockcroft, Arja Karjalainen