Abstract: The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including ultrasound and optical coherence tomography. The imaging probe uses electrostatic discharge for actuating a metalized cantilever which holds the end portion of imaging assembly which emits energy in the imaging probe device by holding the cantilever at a potential such that it is neither grounded or charged such that the only electrical path to ground is through a dissipative polymer forming part of the device which is enveloped by a wire or coil held at ground potential. A high voltage electrode attracts the metalized cantilever and the dissipative polymer is used to connect to the cantilever to ground causing the cantilever to move about thereby scanning the region in front of the probe.

Abstract: Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of the sample and intensities of light transmitted through the sample at a plurality of locations. The system includes glass plates (10) for compressing the tissue, distance sensors (20, 30), illuminations fibers (40) connected to a light source (70), and collection fibers (50) connected to spectrograph (110). Spatial second derivatives are calculated from products of the thicknesses of the sample and the intensities of the transmitted light for the locations. The data points are compared to detect the region of the sample having an absorption level different from the background level of absorption within the sample. The new systems and method can be used to optically image, detect, and characterize tissue, lesions, such as cancer.

Abstract: The present invention aims at providing an ultrasonic diagnostic apparatus capable of displaying a stable spatial distribution of elastic characteristics for each heart beat without depending on the measurement of blood pressure and the accuracy or stability of such measurement, where an ultrasonic wave transmitted from an ultrasonic probe 13 and reflected by biomedical tissue is input to a computing section 19 by way of a receiving section 15, a delay time control section 16, phase detection section 17 and filter section 18. In accordance with the phase detection signal acquired from the phase detection section 17, the computing section 19 computes a relative elastic characteristic which is an elastic characteristic normalized by an elastic characteristic of an arbitrary reference area in the biomedical tissue. A distribution of relative elastic characteristics computed by the computing section is displayed on a display section 21.

Abstract: Systems, methods and apparatus are provided through which a compact pod insertable into the rectum for Magnetic Resonance Imaging/Magnetic Resonance Spectroscopy (MRI/MRS) examination of the prostate and containing two receive coils, each connected to transmit blocking and pre-tuned trap circuitry which can be superimposed within the pod in close proximity, can, without either circuit interfering with the other, efficiently gather, for imaging and tissue analysis, radio frequency signals emanating from magnetically disturbed nuclei in prostate tissue.

Abstract: An ultrasound imaging system includes an imaging probe having an array of transducer elements that is flat and relatively elongated in the azimuth direction and is curved outwardly in the elevation direction. As a result, when the transducer elements are scanned in a step-wise manner, the acoustic pattern of the probe diverges in the elevation direction. The probe therefore provides a large field of view in the near field despite using relatively few transducer elements. The probe also includes sub-array beamformers to delay signals transmitted and received from the transducer elements in respective sub-arrays. The received signals are coupled to an imaging system which includes a signal path that processes the received signals into signals corresponding to a volumetric image. A display coupled to the signal path can then show a volumetric image of anatomical features in a volumetric region adjacent the array of transducer elements.

Abstract: The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method.

Abstract: A method for assessing mechanical properties of an elastic material includes obtaining volumetric ultrasound data sets of the elastic material in two different states of compression. First ultrasound image data of a first hypersurface region of interest (ROI) is selected from a first of the data sets, and second ultrasound image data of a second hypersurface ROI is selected from a second of the data sets. The first ultrasound image data and the second ultrasound image data are compared to determine motion within the elastic material. If out of ROI motion of the elastic material is not less than a specified or predetermined amount and if an allowed number of iterations has not been met, the orientation of at least one ROI is changed and a portion of the process is iterated. Otherwise, an indication of motion resulting from the applied compression within the elastic material is displayed.

Abstract: A system for selectively disabling a surgical instrument operating in a surgical site of a region of interest of a living subject.

Abstract: A non-invasive method of characterizing burn injuries using near infrared spectroscopy is described. In the method, a beam of light is emitted into the burnt tissue portion at two or more different tissue depths. The spectra are then compared using multivariate analysis to determine diagnostic regions of the spectra. This information is used to categorize the burn. In some cases, the diagnostic regions correspond to wavelengths related to the hemodynamics of the tissue portion. The spectra can also be repeated over time, thereby allowing trends and changes in the spectra to be measured. This data is in turn used to categorize the burn as either a superficial burn, partial thickness burn, deep partial burn or a full thickness burn. Once the burn has been categorized, the clinician can intervene as needed to treat the burn.

Abstract: A transmit sequence for contrast agent imaging that improves sensitivity and minimizes image artifacts. The number of pulses and the interleaving of spatially distinct pulses between spatially co-linear pulses are selected such that a substantially similar pulse sequence for substantially each line in a scanned region is generated. A collateral pulse from a different scan line is interleaved between at least two imaging pulses along a scan line of interest. Such pulse sequences provide sensitive contrast agent imaging with minimized spatial variation. In another aspect, responsive signals representing the first and second scan lines are obtained. Intensities associated with the signals are determined. The intensities associated with the first scan line are compared to a value.

Abstract: An improved ophthalmic instrument for estimating aberrations in the eyes of a patient and providing the patient with a view of optical correction of the aberrations so as to provide instant feedback as to the accuracy of the estimated aberrations. The ophthalmic instrument comprises an adaptive optic subsystem for sensing and correcting estimated aberrations in a patient's eye, and a fixation target providing a view of correction of the estimated aberrations. The adaptive optics subsystem includes a wavefront sensor and a multi-stage phase compensator. The multi-stage phase compensator includes a first stage for compensating for a defocus component of the estimated aberrations, and at least one other additional stage for compensating other higher order components of estimated aberrations. Preferably, the first stage comprises a variable focus lens for defocus correction, and the additional stage(s) comprises a deformable mirror for correction of higher order aberrations estimated in the eye.

Abstract: The system includes an ultrasound apparatus which provides successive images of a bladder during the voiding process, the images being approximately one second long so as to provide an accurate picture of the action of the bladder during voiding. The images are then processed to form a substantially continuous moving image, i.e. a video or motion picture. The video covers approximately five minutes so as to capture the entire voiding event. The system is initiated typically by the user by pressing a button or other implement on the ultrasound apparatus which is carried by a belt or on a garment adjacent the abdomen of the user. Several processing techniques are used to compensate for any movement of the user or the device during the voiding process so as to provide a coherent and continuous moving image of the bladder during the voiding process.

Abstract: A passive sensor system utilizing ultrasonic energy is disclosed. The passive sensor system includes at least one ultrasonically vibratable sensor and an ultrasonic activation and detection system. The sensor has at least one vibration frequency which is a function of a physical variable to be sensed. The ultrasonic activation and detection system excites the sensor and detects the vibration frequency from which it determines a value of the physical variable. The sensor includes a substrate having at least one cavity therein, and a vibratable membrane overlying the cavity. Another preferred embodiment of the sensor is a compensated sensor pair including a first sensor whose vibration frequency is responsive to the physical variable to be sensed, and a second sensor whose vibration frequency is non-responsive to the physical variable to be sensed.

Abstract: An apparatus for measuring cervical diameter comprises a support structure and measurement devices for detecting changes in cervical diameter, either directly or indirectly through changes in the size of the support structure. The support structure may conform to a cervical surface, typically being a peripherally expansible lumen or expansible structure. Alternatively, the support structure may engage the vaginal wall or fornices. Measurement devices may include gages which determine change in sizes of an expansible loop, electronic devices for measuring changes in transmitted or reflected energy, or combinations thereof. The devices are suitable for use on ambulatory patients and in out-patient situations.

Abstract: Impedance across a load, such as a pair of face-to-face electrodes, or across electrodes in contact with a patient's chest cavity, respectively, is modeled as a resistor in series with a capacitor, wherein the reactance component of the impedance equals 2.pi.*frequency/capacitance. A reference square wave voltage is applied to the load in series with a selected load resistor, and a response voltage is measured across the load. Both the reference voltage and the response voltage are then used to estimate a transfer function between them. Equating this transfer function to a resistor-capacitor circuit model results in estimation of the actual resistance and capacitance components of the true impedance.

Abstract: Improvements in electro-optical instruments operable in body ducts, such as catheters, endoscopes, laparascopes and free travelling capsules adapted to pass through the body ducts. Methods for using same to detect and treat diseases such as cancer cells and body tissue. Medical materials, such as drug compounds usable with such instruments, are provided for detecting, marking and treating diseases such as cancer and preventing the spread of cancer. An instrument is provided which is capable of detecting a malady, such as a tumor, cancer,lesion, ulcer or other type of wound in a body duct of a living being which instrument may also be automatically operated to treat such a malady, such as by performing a surgical operation thereon.

Abstract: A microwave antenna senses the temperature of tissue into which a fluid is to be injected. The fluid is injected by a needle or other vascular entry device connected to a fluid injector by a connector tube. The fluid temperature is measured by a temperature sensor attached to the connector tube. An alarm processor determines whether an extravasation occurs by comparing a temperature discrimination function derived from tissue temperature taken at different times with a calculated threshold value. The threshold value is calculated from the tissue temperature and the fluid temperature. The threshold value is recalculated and updated continuously during the fluid injection.

Abstract: A new laser perforator has been invented for perforating skin with a perforation to permit blood under a surface of the skin to flow out, the perforator in one embodiment having a laser light source for producing an output laser beam, and a mode distribution apparatus for intercepting the output laser beam to control distribution of laser energy of the output laser beam across the perforation of the skin. A laser perforator is disclosed for perforating skin with a perforation to permit blood under a surface of the skin to flow out, the perforator in one embodiment having a laser light source for producing an output laser beam having an energy level between about 0.1 to about 2.0 Joules, the perforation ranging in diameter between about 0.1 to about 2.0 millimeters, in depth between about 0.5 to about 4.0 millimeters, and ranging in width between about 0.05 to about 0.2 millimeters. A method is also disclosed for perforating skin for blood sampling.

Abstract: A 3D field of view ultrasound image volume is derived from correlated frames of ultrasound image data. An operator manually translates an ultrasound probe across a patient target area. Frames of sensed echo signals are processed to detect probe motion using beam data registration and correlation techniques. Motion is detected by correlating the frames for probe translation among as many as 6 degrees of freedom. Image registration then is performed for correlated portions to accumulate a large ultrasound image. Such image encompasses an area larger than a single field of view image frame for the given manually-scanned transducer probe.

Abstract: The invention provides a surface marker for use in ultrasonography. The marker comprises a material which attenuates a portion of the ultrasound energy applied to an ultrasound field including the marker and tissue underlying the marker. When placed on the surface of the skin above a particular tissue structure and then imaged, the marker projects a shadow of reduced sonic energy into the underlying tissue structure. The shadow provides direct visual evidence that the tissue beneath the marker has been imaged. The shadow projected by the marker may also be used to locate the image of an area of particular clinical interest within the tissue structure, such as a tumor or cyst.