Patents Examined by Francisco Prats
  • Patent number: 6835558
    Abstract: An efficient method for producing high quality beta glucan enriched soluble dietary fiber products is described. An aqueous extraction slurry of beta glucan-containing grain material is homogenized, acidified and enzymatically digested to reduce viscosity and optimize separation of insolubles from the aqueous extract solution. The resulting extract is heat processed to precipitate denatured protein components and subsequently dried or otherwise processed to provide the products for use as food additives or dietary supplements.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: December 28, 2004
    Assignee: General Mills, Inc.
    Inventors: Bernhard H. Van Lengerich, Olaf Gruess, Friedrich P. Meuser
  • Patent number: 6825031
    Abstract: Materials which are not themselves storage-stable at room temperature are made suitable for storage by mixing them with a carrier substance and spray drying the resulting mixture so as to form particles containing both the material and the carrier substance in which the carrier substance is in an amorphous, i.e. glassy or rubbery, state. Formation of such a composition greatly enhances stability. The material stored may be a biological material such as an enzyme, the components of a chemical reaction such as reagents for carrying out an assay, or even viable biological cells.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 30, 2004
    Assignee: Nektar Therapeutics
    Inventors: Felix Franks, Ross Henry Hatley, Sheila Frances Mathias
  • Patent number: 6821757
    Abstract: A method for separating and/or isolating circular nucleic acids from a mixture having different species of nucleic acids other than circular nucleic acids wherein the mixture is treated under alkaline conditions at a pH>8 with a solid matrix consisting essentially of a silica material in presence of at least one chaotropic substance.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: November 23, 2004
    Assignee: QIAGEN GmbH
    Inventors: Philippe Sauer, Jie Kang
  • Patent number: 6812001
    Abstract: A process for the isolation of crystalline carotenoid compound from microbial biomass comprising disrupting the microbial cell walls, separating cellular debris from the carotenoid-containing residue, washing one member of the group consisting of the microbial biomass, the disrupted cell mass and the carotenoid-containing reside with a solvent to remove lipid, suspending the obtained carotenoid crystals in water to float the crystals, recovering the crystals and, optionally, further purifying the crystals which avoids the use of large amounts of solvent of carotenoid extraction process.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 2, 2004
    Assignee: DSM N.V.
    Inventors: Mieke Sibeijn, Robertus Mattheus De Pater
  • Patent number: 6800304
    Abstract: The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: October 5, 2004
    Assignee: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Chien-Jen Shih, Je-Yie Lin, Pey-Chyi Wu, Mo-Chi Cheng
  • Patent number: 6797284
    Abstract: Phytopharmaceutical food products which contain plant extracts and aminoacids and which can be used in order to reduce tobacco smoke addiction.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: September 28, 2004
    Inventor: Ursula Mariah Rothlin
  • Patent number: 6783757
    Abstract: A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The genomeceutical compound may include a sugar (such as a milk sugar), glucans, galactose and/or related material. The composition may also include one or more of a protease, peptidase or phytase. The inclusion of phospholipids, disaccharides, lipases and/or related substances in a composition for treating autism spectrum disorders and the function they provide is also disclosed.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 31, 2004
    Assignee: Kirkman Group, Inc.
    Inventor: Mark A. Brudnak
  • Patent number: 6780438
    Abstract: A dietary supplement for mammalian consumption, and particularly human consumption, for the purpose of stimulating the immune system, inhibiting infection and increasing tissue repair and healing. Comprising colostrum, lactoferrin, and with modified citrus pectin as an optional component, the dietary supplement is administered in ‘mucosal delivery format’: a dosage form that promotes effective absorption through the lining of the oral cavity.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: August 24, 2004
    Assignee: Lactoferrin Products Company
    Inventors: Marcus B. Gohlke, Richard H. Cockrum
  • Patent number: 6773708
    Abstract: The use of at least one type of xanthophylls for the production of a medicament for suppression of excessive Th1 cell mediated immune responses and stimulation of Th2 cell mediated immune responses in a patient during ongoing infection and/or inflammation in said patient is disclosed. Excessive Th1 cell mediated immune responses are caused by such autoimmune diseases and chronic viral and intracellular bacterial infections as Psoriasis vulgaris, Multiple sclerosis (MS), Rheumatoid arthritis, Crohn's disease, insulin-dependent diabetes mellitus, Tuberculosis (TB), Acute graft-versus-host disease (transplant rejection) and HIV virus infection. The preferred type of xanthophyll is astaxanthin, particularly in a form esterified with fatty acids, obtainable by for example culturing the algae Haematococcus sp.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: August 10, 2004
    Assignee: AstaReal AB
    Inventors: Åke Lignell, Per Böttiger
  • Patent number: 6770463
    Abstract: There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: August 3, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: John Francis Chiarello, Brian Lee Buckwalter, Timothy Claude Barden
  • Patent number: 6767717
    Abstract: The present invention provides a method of detecting a peroxide-based explosive in a sample suspected of consisting of or comprising such explosive, which method comprises dissolving said sample in a suitable organic solvent, contacting the solution with an aqueous solution of a strong acid capable of decomposing said explosive to release hydrogen peroxide, and contacting the resulting mixture with a peroxidase enzyme. The invention also provides a kit for use in the method of the invention.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: July 27, 2004
    Inventors: Harel Itzhaky, Ehud Keinan
  • Patent number: 6767563
    Abstract: An inventive and proprietary food supplement formula per unit to enhance the body's natural immune function against viral and infectious diseases and cancer. The food supplement per unit in liquid or capsule gel caplets consists of: 200 to 600 mg. of Chrysin; 200 to 600 mg. of Coriolus Versicolor PSK; 50 to 150 mg. of 3,3′ Diindolylmethane DIM; 50 to 150 mg. of Resveratrol 25 %; 50 to 150 mg. Turmeric Extract 95 %; 40 to 140 mg. Green Tea Extract 95 %; 20 to 80 mg. of Quercitin Dihydrate 99 %; and 15 to 75 mg. of Phosphatidyl Choline 50 %. Advantageously, each dose unit preferably includes 25 mg to about 150 mgs. of Myricetin.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: July 27, 2004
    Inventor: Michael D. Farley
  • Patent number: 6764841
    Abstract: The invention relates to a process for producing glucose-1-phosphate, which contains the steps of culturing bacteria of the genus Corynebacterium in a medium containing a saccharide and at least 1 mM of phosphoric acid or a derivative or salt thereof, and collecting glucose-1-phosphate produced and accumulated in the medium. A mass of G-1-P can be provided without conducting complicated steps which are required of the enzymatic process.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: July 20, 2004
    Assignee: Kao Corporation
    Inventors: Kazuaki Igarashi, Katsuya Ozaki
  • Patent number: 6761913
    Abstract: Biologically active extracts of celery seed are produced by controlled ethanolic extraction, distillation and drying, and further processing by supercritical fluid extractions (SFE), and may be further fractionated by column fractionation, distillation, LiAlH reduction and the like. These extracts possess activity for the treatment and prevention of acute and chronic pain, inflammation and gastrointestinal irritation.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: July 13, 2004
    Assignee: International Celery Development Alliance PTY. Ltd.
    Inventors: Desley Ethel Butters, Craig Kendall Charles Davis, Ross Peter McGeary, Michael Christopher Powanda, Kim Drummond Rainsford, Michael Wellesley Whitehouse
  • Patent number: 6759230
    Abstract: A novel microorganism producing a nontoxic, non-antigenic exopolysaccharide is taught. The exopolysaccharide has neutral sugars migrating at the same rate as mannose, fucose, fructose and galactose, acidic sugars migrating at the same rate as fucose and amine sugars migrating at the same rate as glucose and fucose, and wherein the ratio of galactose:fucose:glucose:mannose is about 1:2:3:6. The microbe and the exopolysaccharide have uses as a biofilm in geologic applications and have several consumer uses as food and drug polymers and use as a plasma extender.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: July 6, 2004
    Assignee: The Board of Regents, The University of Texas
    Inventors: Lee A. Bulla, Jr., Mehmet Candas
  • Patent number: 6759061
    Abstract: A food supplement formulation effective to improve the function of the liver comprises selenium, milk thistle seed, phosphatidyl choline, dandelion root, l-methionine, l-taurine, N-acetyl-cysteine, alpha lipoic arid, artichoke leaf, green tea leaf, turmeric root, belleric myrobalan fruit, boerhavia diffusa, eclipta alba, wedelolactones tinospora cordifolia, andrographis paniculata, and picrorhiza kurroa.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: July 6, 2004
    Assignee: Renew Life, Inc.
    Inventors: Brenda F. Watson, Leonard O. Smith
  • Patent number: 6752988
    Abstract: A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a native or modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria. The lytic enzyme is selected from a group consisting of shuffled lytic enzymes, chimericlytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: June 22, 2004
    Assignees: New Horizons Diagnostic Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6746695
    Abstract: This invention relates to methods of extracting and purifying bioactive substances from various plants and herbs. More specifically the invention relates to methods of extracting and separating bioactive substances from various plants and herbs, such as Kava root, Byrsonima species, Aesculus californica, Crataegus mexicana, Simmondsia chinensis, Pfaffia species, Alternanthera repens, Bursera species, Turnera species, Perezia species, Heimia salicifolia, Psidium species, Enterlobium species, Ptychopetalum olacoides, Liriosma ovata, and Chaunochiton kappleri, using supercritical fluid extraction and/or fluorocarbon solvent extract. The present invention further relates to separation of bioactive substances contained in extracts using packed column supercritical fluid chromatography or HPLC where dense gas with or without modifiers is the mobile phase.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: June 8, 2004
    Assignees: Armadillo Pharmaceuticals, Inc., Virginia Tech. Intellectual Properties, Inc.
    Inventors: Michael Z. Martin, Mehdi Ashraf-Khorassani, Larry Taylor
  • Patent number: 6743598
    Abstract: The present invention provides methods for simultaneously assessing microbial phosphoglucose isomerase, ketol-isomerase and glucosamine-6-phosphate acetyltransferase activities, by measuring the production of Coenzyme A (CoA). The present invention finds use in the isolation of new classes of antifungal drugs, wherein the compounds have the ability to inhibit fungal glucose utilization.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: June 1, 2004
    Assignees: MycoLogics, Inc., Toyama Chemical Co., Ltd.
    Inventors: Claude P. Selitrennikoff, Mitsunori Nakata
  • Patent number: 6737257
    Abstract: The present invention is directed to use of hyperthermophilic enzymes for industrial chemical redox reactions such as ethanol production. The present invention is especially useful for the coupled synthesis and recovery of alcohols whereby recovery of alcohol is simplified.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: May 18, 2004
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Paul Blum