Patents Examined by Frank S. Hou
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Patent number: 11931360Abstract: Compositions and methods for treatment of cancer according to aspects of the present disclosure comprise compounds comprising or consisting of: structural formula (I) or (II) disclosed herein, or a salt, isomer, or derivative thereof.Type: GrantFiled: June 23, 2022Date of Patent: March 19, 2024Assignee: Wayne State UniversityInventors: Isaac J. Powell, Navnath S. Gavande
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Patent number: 11919879Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.Type: GrantFiled: June 15, 2022Date of Patent: March 5, 2024Assignee: Celgene CorporationInventors: Jeffrey M. Schkeryantz, Karin Worm, Rulin Ma, Patrick W. Papa
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Patent number: 11905230Abstract: The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.Type: GrantFiled: May 24, 2018Date of Patent: February 20, 2024Assignee: CHINA PHARMACEUTICAL UNIVERSITYInventors: Hai Qian, Wenlong Huang, Chunxia Liu, Jianyong Yang
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Patent number: 11891406Abstract: A method for enhancing the conductivity of MOF-5 by the development of an MOF-5 polymer composite material. The composite material incorporates a conductive polymer, preferably polyaniline, in the solvo-thermal synthesis pathway of MOF-5. The electrically conductive MOF-5 composite exhibits electric conductivity three orders of magnitude higher than that of MOF-5 while maintaining the crystallinity, robustness, and thermal stability of MOF-5.Type: GrantFiled: September 5, 2019Date of Patent: February 6, 2024Assignee: King Fahd University of Petroleum and MineralsInventors: Abdul Malik P. Peedikakkal, Abdul-Rahman Al-Betar, Ammar Hussain Al-Mousa
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Patent number: 11883394Abstract: Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about 0.50 to about 3.3 m2/g; and crystals of aripiprazole lauroxil produced by such processes.Type: GrantFiled: March 24, 2021Date of Patent: January 30, 2024Assignee: ALKERMES PHARMA IRELAND LIMITEDInventors: Wilfredo Morales, Tarek A. Zeidan, Renato A. Chiarella, Steven G. Wright, Jason M. Perry
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Patent number: 11878973Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.Type: GrantFiled: May 25, 2022Date of Patent: January 23, 2024Assignee: NOVARTIS AGInventors: Vincent Bordas, Jvan Brun, Markus Furegati, Jacques Hamon, Jürgen Hans-Hermann Hinrichs, Philipp Holzer, Fatma Limam, Henrik Möbitz, Sandro Nocito, Simone Plattner, Niko Schmiedeberg, Joseph Schoepfer, Ross Sinclair Strang, Frédéric Zecri
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Patent number: 11866420Abstract: The present invention relates to novel hydrochloride salt forms of N-(2?,4?-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1?-biphenyl]-3-yl)cyclopropanesulfonamide (I). Compound (I) is a selective inhibitor of FGFR/VEGFR kinase families and is useful in the treatment of cancer.Type: GrantFiled: September 5, 2019Date of Patent: January 9, 2024Assignee: Aurigene Oncology LimitedInventors: David Jonaitis, Oskari Karjalainen
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Patent number: 11858918Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.Type: GrantFiled: April 19, 2022Date of Patent: January 2, 2024Assignee: GILEAD SCIENCES, INC.Inventors: Megan K. Armstrong, James S. Cassidy, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Chao-I Hung, Kavoos Kolahdouzan, David W. Lin, Michael L. Mitchell, Ezra Roberts, Scott D. Schroeder, Nathan D. Shapiro, James G. Taylor, Rhiannon Thomas-Tran, Nathan E. Wright, Zheng-Yu Yang
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Patent number: 11840512Abstract: Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2?(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuK? characteristic X-rays.Type: GrantFiled: July 7, 2022Date of Patent: December 12, 2023Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Naohiko Kanai, Takayuki Yasutomi, Ryosuke Hirota
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Patent number: 11839607Abstract: A memantine paroxetine cocrystal salt and its preparation method, pharmaceutical composition and application thereof are provided. The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a multi-target drug. The preliminary pharmacokinetic experiments showed that the main pharmacokinetic parameters of cocrystal salt and memantine, such as T1/2, Tmax, Cmax and AUC(0-?), were significantly different. The results also showed that cocrystal salt could improve drug absorption, blood drug concentration, bioavailability and curative effect. This provides a material basis for reducing dosage and adverse drug reactions. In addition to that the cocrystal salt of this invention can be used as a multi-target drug, it can also combine with other drugs of different action mechanisms to form compound preparations or be used in combination, so as to obtain unexpected clinical efficacy.Type: GrantFiled: February 22, 2019Date of Patent: December 12, 2023Assignee: HEFEI KEDA BIO-TECHNOLOGY CO. LTDInventors: Ke Wang, Qianliu Cheng, Zonggui Wang, Yan Geng, Xun Zhao
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Patent number: 11839603Abstract: An object of the present invention is to provide an ascorbic acid formulation that can be prepared by a simple method, and that has a reduced unpleasant taste and coloration. The inventors found that an ascorbic acid formulation that is in the form of a water-in-oil type emulsion, that comprises an aqueous phase with a pH of 4 or more and an average particle size of 300 nm or less, and that has a mass ratio of water/ascorbic acid of 0.05 to 0.40 has a reduced unpleasant taste and coloration; and accomplished the present invention. Additionally, the present invention can be prepared by a simple method.Type: GrantFiled: January 28, 2019Date of Patent: December 12, 2023Assignee: FUJI OIL HOLDINGS INC.Inventors: Arata Hashimoto, Masaharu Kato