Abstract: There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactiviting sperm. There is provided articles for use in these methods.
Type:
Grant
Filed:
March 22, 1991
Date of Patent:
May 24, 1994
Assignee:
E. B. Michaels Research Associates, Inc.
Abstract: New methods and feed compositions are disclosed for enhancing the reduction of coccidial-induced intestinal lesions in poultry and for enhancing shank pigmentation in poultry. Such methods comprise coadministering zeolite and coccidiostats, such as in a feed mixture or by separate administration.
Abstract: Vaginal pharmaceutical compositions administrable through the topical route, particularly in the form of vaginal foams and creams containing a therapeutically effective amount of rifaximin (Common International Denomination) are useful in the treatment of vaginal infections, particularly bacterial vaginosis.
Type:
Grant
Filed:
June 16, 1992
Date of Patent:
May 24, 1994
Assignee:
Alfa Wassermann S.p.A.
Inventors:
Marchi Egidio, Rotini L. Gabriele, Desai Subhash, Grillli Massimo
Abstract: A composition is disclosed containing non-esterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.
Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
Type:
Grant
Filed:
January 27, 1993
Date of Patent:
May 24, 1994
Assignee:
Monsanto Company
Inventors:
Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
Abstract: The growth rate of meat-producing animals as well as the yield and quality of the meat obtained therefrom is improved by administering to the animal prior to its sexual maturation an effective amount of a female gonadal steroidal compound; namely, an estrogen or progestagen compound and preferably a mixture thereof, sufficient to delay development of the gonadal function of the animal, e.g., spermatogenesis. Such administration is terminated sufficiently prior to slaughter of the animal that the administered steroidal compound has been substantially completely removed from the animal's system which before slaughter exhibits levels of the corresponding natural hormones therein substantially within normal limits. In mammals, administration is preferably by injection, but in fish, shellfish and poultry, the active steroidal compound is incorporated at low levels in the usual feed therefor.
Type:
Grant
Filed:
May 4, 1992
Date of Patent:
May 24, 1994
Assignee:
International Foundation for Biochemical Endocrinology
Inventors:
Vladimir Pantic, Nestor Sijacki, Svetislav Kolaric
Abstract: The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a pyrimidinyl-piperazine ring structure of which the most preferred member is buspirone. These compounds are administered to a variety of different domestic animals and household pets exhibiting behavioral problems which often are refractory to other modes of treatment.
Abstract: A method is provided for protecting against and/or treating ulcerative gastrointestinal conditions, including anti-inflammatory drug-induced gastrointestinal ulcers, using a thromboxane A.sub.2 receptor antagonist. In addition, a combination is provided which includes a thromboxane A.sub.2 receptor antagonist and an anti-inflammatory agent which combination may be used to treat inflammatory conditions, such as arthritis, while inhibiting formation of and/or treating gastrointestinal ulcers.
Type:
Grant
Filed:
December 23, 1992
Date of Patent:
May 17, 1994
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Bernard Rubin, Martin L. Ogletree, Eugene H. O'Keefe, A. K. Gunnar Aberg
Abstract: A method of combatting, e.g., preventing as well as treating, a disease state such as cystic fibrosis, neonatal hypoxemia, pulmonary hypertension, adult respiratory distress syndrome, psoriasis, spondyloarthritis, rheumatoid arthritis, gout, inflammatory bowel disease, myocardial infarctions, and/or osteoporosis in an animal subject, by administering to the animal subject an amount of an organic boron compound which is effective thereagainst. The organic boron compounds usefully employed in the method of the invention include any suitable organic boron-containing compounds, such as Lewis base-boron adducts; a preferred class of organic boron compounds useful in such method includes boron analogs of .alpha.-amino acids, and the corresponding amides and esters of such amino acids. A method is also disclosed of inhibiting enzyme activity in in vitro or in vivo systems comprising administering to such system an enzyme-inhibiting amount of an organic boron compound.
Type:
Grant
Filed:
September 14, 1993
Date of Patent:
May 17, 1994
Assignee:
Boron Biologicals, Inc.
Inventors:
Bernard F. Spielvogel, Anup Sood, Iris H. Hall
Abstract: The use of a pharmaceutically acceptable cholinesterase inhibitor or a prodrug therefor for the treatment of fatigue syndromes, including chronic fatigue syndrome, post-infectious fatigue syndromes, fatigue syndromes associated with human immunodeficiency virus (HIV) infection or with preeclampsia. The acetyl cholinesterase is preferably one that acts substantially selectively at nicotinic receptor sites, and which has selectivity for acetyl cholinesterase as opposed to butyryl cholinesterase. Compounds of the invention include galanthamine and galanthamine derivatives.
Abstract: Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.
Type:
Grant
Filed:
January 19, 1989
Date of Patent:
May 17, 1994
Assignee:
Bracco - Industria Chimica S.p.A.
Inventors:
Michel Schneider, Herve Tournier, Bernard Lamy
Abstract: A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a macrocyclic compound composed of aryl ring subunits connected one to another by ring-attached bridge linkages, and containing sulfonic acid-derived substituents carried on non-bridge atoms of the subunits.
Abstract: The pharmaceutical composition according to the invention consists essentially of:i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium, manganese, iron, cobalt, nickel, copper, zinc and molybdenum, which compounds do not precipitate with each other or with the other components of the composition and exhibit a neutral or acidic pH in an aqueous medium;ii) glycine;iii) glycerol;iv) L-(+)-ascorbic acid;v) succinic acid;vi) a neutral or acidic and water-soluble, pharmaceutically acceptable salt of ethylenediamine tetraacetic acid;vii) potassium sodium tartrate; andviii) L-(+)-tartaric acid. The composition can be used for the treatment of mucoviscidosis and chronic pain syndromes deriving from locomotor diseases or accompanying diseases of tumorous origin.
Abstract: N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
Type:
Grant
Filed:
February 25, 1993
Date of Patent:
May 17, 1994
Assignee:
State of Oregon, acting by and through the Oregon State Board of Higher Education
Abstract: The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, IL-1 or IL-2 and the like. Said method involves administering, preferably intravascularly, a therapeutically effective amount of dobutamine and an inhibitor of nitric oxide formation from arginine. Although preferable administration is intravascular, it is contemplated that other parenteral administration routes such as intraperitoneal, intramuscular or subdermal injection, for example, may prove useful. Enteral or topical administration of arginine analogs may also prove beneficial under certain clinical conditions.
Type:
Grant
Filed:
May 29, 1992
Date of Patent:
May 17, 1994
Assignees:
Board of Regents, the University of Texas System, Cornell Research Foundation, Inc.
Inventors:
Robert G. Kilbourn, Steven S. Gross, Owen W. Griffith
Abstract: Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.
Abstract: Novel bleaches are reported. The bleaches are of the N-sulfonyloxaziridine type. Substrates such as fabrics may be bleached in an aqueous solution containing the oxaziridine.
Type:
Grant
Filed:
July 16, 1991
Date of Patent:
May 10, 1994
Assignee:
Lever Brothers Company, Division of Conopco, Inc.
Abstract: This invention provides new uses for the drugs of the thioureylene class and thiabendazole. These new uses include methods of treatment for a variety of conditions and diseases, including psoriasis, other atopic dermatoses and inflammatory conditions having an autoimmune basis, as well as other autoimmune diseases, including rheumatic disease, and transplant rejection.