Abstract: A method of controlling intraocular pressure by nonchronic, topical administration of a clonidine derivative immediately prior and post trauma to the affected eye.

Abstract: A pharmaceutical composition, preferably ophthalmic solution or ophthalmic suspension, useful for treating animals of the mammalian species, including humans, to reduce or maintain intraocular pressure in the eye contains as its pharmacologically active ingredient one or more compounds of the formula ##STR1## where X is O, S or NH; n is an integer with the values of 0, 1 or 2; when n is 0 then R.sub.1 is lower alkyl having 1 to 6 carbon atoms and R.sub.2 is H or lower alkyl having 1 to 6 carbon atoms; when n is 1 or 2, then R.sub.1 and R.sub.2 are methylene (CH.sub.2), or methylene substituted with an R.sub.5 group where R.sub.5 is lower alkyl of 1 to 6 carbons; R.sub.3 and R.sub.4 independently are H or lower alkyl having 1 to 6 carbons; R.sub.6 is H or lower alkyl of 1 to 6 carbons.

Abstract: The present invention provides an agent for treating ischemic brain damage comprising 3-sulfamoylmethyl-1,2-benzisoxazole or its alkali metal salt as an active ingredient. This agent can be used for the prevention and/or treatment of cerebral ischemia-induced intracranial diseases or various symptoms associated therewith in mammals including human beings.

Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.

Abstract: The present application discloses a novel mammalian livestock feed additive containing a selective avian taste aversive agent, preferably dimethyl anthranilate, which is at least partially entrapped in an edible solid vehicle to improve its taste persistency. In the preferred embodiment, the edible vehicle is a modified food starch which is spray dried with the avian taste aversive agent. The disclosed livestock feed additive may be incorporated in a livestock feed to reduce the amount of feed lost to avian species, and to reduce the likelihood that mammals will be infected by avian transmitted diseases such as transmissible gastroenteritis. Alternatively, a mammalian poison is disclosed comprising an avian taste aversive additive which will increase the amount of that poison available for ingestion by mammalian target species and decrease the likelihood of secondary poisoning of a number of endangered species.