Abstract: The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP?, PTP?, PTP?, PTP?, PTP?, PTP?, PTP?, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.

Abstract: Methods and pharmaceutical compositions employing (+) cetirizine, (−) cetirizine, or racemic cetirizine, or a pharmaceutically acceptable salt thereof, and a leukotriene inhibitor, or a pharmaceutically acceptable salt thereof, or decongestant for the treatment, management, and/or prevention of inflammation, asthma or symptoms thereof, allergic disorders such as allergic rhinitis, and dermatitis.

Abstract: The invention relates to the use of cycloventabenzofuran derivatives for the production of a medicament for the treatment of nuclear factor of &kgr;B-dependent diseases.

Abstract: Cosmetic compositions comprising at least one film-forming polymer, in a cosmetically acceptable medium, wherein said at least one film-forming polymer has, at the polymer concentration of the composition, a mechanical profile, measured in an aqueous-alcoholic medium comprising 20% by volume of ethanol, defined by at least: (i) an attachment angle &agr; of greater than 47°, and (ii) if &agr; is greater than or equal to 90°, a maximum detachment force Fmax<5 newtons.

Abstract: Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques.

Abstract: It has been found that non-blushing coatings of high gloss, long pot life and fast cure time may be obtained by using an epoxy curing agent which comprises an epichlorohydrin-metaxylylenediamine reaction product selected from the group consisting of N,N'-bis(3-aminomethylbenzyl)-2-hydroxytrimethylenediamine, the higher oligomers of N,N'-bis(3-aminomethylbenzyl)-2-hydroxytrimethylenediamine and mixtures thereof and a melting point depressant such as a benzyl alcohol or water and an alcohol solvent and, optionally, a tertiary amine such as N,N'-bis(3-(dimethylamino)propyl)-urea.

Abstract: The present invention provides a procedure for at least partial dissociation of crumb rubber vulcanate network, including automobile tires, and for the incorporation of this treated rubber into stable bitumen compositions. The at least partially dissociated rubber vulcanate network may be used independently as a bitumen modifier, or a stabilizing agent for ground vulcanate rubber dispersions in bitumen or as a steric stabilizer in dispersion of polyolefins in bitumen. The at least partially dissociated rubber vulcanate network materials are produced in situ in bitumen or produced separately and subsequently incorporated into bitumen and the bituminous compositions are useful materials for a variety of applications. Modifications are possible within the scope of this invention.

Abstract: Poly(arylene ether ketones) are prepared by a Friedel-Crafts polymerization wherein a gelled reaction mixture is produced, by permitting the polymerization to proceed in a first reactor until substantial partial polymerization has occurred, but before substantial gelation of the reaction mixture; transferring the partially polymerized reaction mixture into a piston-equipped second reactor; permitting polymerization to continue in the second reactor until a gelled, polymerized reaction mixture has been obtained; and discharging the polymerized reaction mixture from the second reactor by stroking the piston.