Patent number: 4895803
Abstract: A method for decontaminating cell cultures comprising contacting cell cultures with quinolone- and 1,8-naphthyridonecarboxylic acids of the formula (I) ##STR1## in which R.sup.1 represents methyl, ethyl, propyl, isopropyl, cyclopropyl, vinyl, 2-hydroxyethyl, 2-fluorethyl, methoxy, amino, methylamino, dimethylamino, ethylamino, phenyl, 4-fluorophenyl or 2,4-difluorophenyl,R.sup.2 represents hydrogen, alkyl having 1 to 4 carbon atoms, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,R.sup.3 represents methyl or a cyclic amino group such as ##STR2## in which R.sup.4 represents hydrogen, alkyl having 1 to 4 carbon atoms, 2-hydroxyethyl, allyl, propargyl, 2-oxopropyl, 3-oxobutyl, phenacyl, formyl, CFCl.sub.2 --S--, CFCl.sub.2 --SO.sub.2 --, CH.sub.3 O--CO--S--, benzyl, 4-aminobenzyl or ##STR3## R.sup.5 represents hydrogen or methyl, R.sup.6 represents hydrogen, alkyl having 1 to 4 carbon atoms, phenyl or benzyloxomethyl,R.sup.
Type:
Grant
Filed:
October 22, 1986
Date of Patent:
January 23, 1990
Assignee:
Bayer Aktiengesellschaft
Inventors:
Gunter E. Hubner, Helmut Brunner, Hans-Joachim Zeiler