Abstract: A composition comprising a pharmaceutically acceptable polysaccharide carrier which has been chemically activated and then linked to platinum in either a +2 or +4 oxidation state through a bidentate oxygen-containing ligand including an amine group coupled to the activated polysaccharide. The composition may be used to link platinum metal remotely to a monoclonal antibody via the oxygen-containing ligand and the polysaccharide carrier such as dextran. The composition is optionally radiolabeled.

Abstract: A new and improved composition and method for profile modification of subterranean formations characterized by high reservoir temperatures and/or harsh brine conditions are disclosed. The new and improved profile modification agents comprise a gelable composition comprising:(a) water;(b) a water-thickening and crosslinkable amount of a water-dispersible copolymer comprising from about 1 to about 99 mol % of units derived from an N,N.sup.1 -dialkylacrylamide monomer copolymerized with from about 1 to about 99 mol % of units derived from acrylic acid or a salt thereof; and(c) an amount of a polyvalent metal sufficient to crosslink the copolymer to form a stable gel. The profile modification agents are effective to alter the permeability of preselected portions of an underground formation by forming strong gels which are stable in harsh brine at temperatures of up to about 120.degree. C. The composition and method are particularly adapted for use in enhanced oil recovery operations.