Patents Examined by G. S. Kishore
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Patent number: 5024832Abstract: A termites trail-marking pheromone which is (3Z,6Z,8E)-dodecatrienol, and a composition which comprises (3Z,6Z,8E)-dodecatrienol as an essential component and another component which is a trail-marking pheromone-like substance, and a method of detecting termites by using this composition or (3Z,6Z,8E)-dodecatrienol.The trail-marking pheromone and composition are highly safe in that they have no residual toxicity, and they have a stable, long-term trail-marking effect for termites. This invention provides a simple and rapid method of detecting termites, and a simple and effective method of capturing termites.Type: GrantFiled: December 13, 1989Date of Patent: June 18, 1991Assignee: Nitto Denko Co. Ltd.Inventors: Tetsuo Omata, Shuji Senda, Tamaki Tanaka, Eriko Kumagai, Chikara Kajimoto, Yutaka Nakazono
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Patent number: 5024841Abstract: Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.Type: GrantFiled: June 30, 1988Date of Patent: June 18, 1991Assignee: Collagen CorporationInventors: George H. Chu, Yasushi Ogawa, John M. McPherson, George Ksander, Bruce Pratt, Diana Hendricks, Hugh McMullin
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Patent number: 5019393Abstract: Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is streptokinase, urokinase, tissue plasminogen activator, ATPase, 5'-nucleotidase, and active fragments and active analogs thereof.Type: GrantFiled: August 3, 1988Date of Patent: May 28, 1991Assignee: New England Deaconess Hospital CorporationInventors: Ralph K. Ito, Frank W. LoGerfo
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Patent number: 5017382Abstract: A process for the preparation of a controlled release composition comprising a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1,000 which comprise polyethylene oxide and are cross-linked through urethane groups.Type: GrantFiled: January 23, 1990Date of Patent: May 21, 1991Assignee: National Research Development CorporationInventors: Mostyn P. Embrey, Neil B. Graham
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Patent number: 5011868Abstract: A denture adhesive base composition comprises a substantially anhydrous mixture of a cationic acrylamide polymer, sodium carboxymethylcellulose and ethylene oxide polymer. A denture adhesive composition including this base composition is provided. A method for formulating the novel denture adhesive base compositions and denture adhesive compositions of the invention is also disclosed.Type: GrantFiled: December 1, 1989Date of Patent: April 30, 1991Assignee: Warner-Lambert CompanyInventor: James J. Keegan
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Patent number: 5010069Abstract: An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferrred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time.Type: GrantFiled: May 15, 1989Date of Patent: April 23, 1991Assignee: Marion Laboratories, Inc.Inventors: Carey B. Bottom, Margaret N. Kwoka
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Patent number: 5004756Abstract: A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises fine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR1## an aqueous medium, and, 0.05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.Type: GrantFiled: August 8, 1989Date of Patent: April 2, 1991Assignees: Lederle (Japan) Ltd., Nisshin Flour Milling Co., Ltd.Inventors: Osamu Ogawa, Ikuo Kishi, Yoshiyuki Tahara, Masanori Sugita
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Patent number: 5004735Abstract: Polyprenols and polyprenyl phosphates are of the formula ##STR1## wherein ##STR2## represents a trans-isoprene unit, ##STR3## represents a cis-isoprene unit, ##STR4## represents a dihydroisoprene unit, l is an integer of 2 to 8, m is 0 or an integer of 5 to 18, n is 0 or 1, the sum of l and m is in the range of 8 to 20, and X represents a hydrogen atom or --PO.sub.3 MM' wherein M and M' may be the same or different and each is a hydrogen atom or a monovalent cation or both M and M' together form a divalent cation. They are useful as a medicament for the inhibition of tumor metastasis.Type: GrantFiled: June 29, 1989Date of Patent: April 2, 1991Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yasushi Okamoto, Yoshiyuki Tahara, Yoshio Mishima
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Patent number: 5002956Abstract: What is disclosed is the use of dissociable heterocycle compounds from the group including aminoacridine, aminocholine and aminopyridine as well as their derivatives substituted on the basic structure, which are present in tautomeric diimine form, for the selective iontophoretic treatment or for production of a pharmaceutical for iontophoretic treatment and relapse prophylaxis of bladder cancer as well as for iontophoretic treatment of malignant skin and mucus membrane tumors.It is further disclosed and proven that the antineoplastic effect observed with use of the above compositions in animal experiments and in clinical treatment is selective and healthy tissue is not damaged.The common denominator for the characteristic and proven antineoplastic selective effect of the three classes of materials is the tautomeric diimine form.Type: GrantFiled: March 22, 1989Date of Patent: March 26, 1991Inventor: Karl H. Thiel
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Patent number: 5001131Abstract: The invention provides a method of relieving inflammation in a mammal inflicted with an imflammatory disease which method comprises treating said mammal with a therapeutically effective amount of a compound of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, loweralkyl, cycloloweralkyl, loweralkoxy, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, loweralkoxycarbonyl, aryl or aralkyl or 7-12 carbon atoms, or R.sup.1 and R.sup.2 taken together, or R.sup.2 and R.sup.3 taken together form a5,6, or 7 membered ring with the carbon atoms to which they are attached, which ring may be saturated or unsaturated and unsubstituted or substituted by loweralkyl or loweralkoxy, R.sup.Type: GrantFiled: June 16, 1989Date of Patent: March 19, 1991Assignee: John Wyeth & Brother LimitedInventors: Roger Crossley, Albert Opalko
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Patent number: 5001170Abstract: A denture adhesive base composition comprises a substantially anhydrous mixture of methyl vinyl ethermaleic acid copolymer, polyvinyl pyrrolidone and ethylene oxide polymer. A denture adhesive composition including this base composition is also provided, the denture adhesive composition optionally including hydroxypropylcellulose. A method for formulating the novel denture adhesive base compositions and denture adhesive compositions of the invention is also disclosed.Type: GrantFiled: December 1, 1989Date of Patent: March 19, 1991Assignee: Warner-Lambert CompanyInventor: James J. Keegan
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Patent number: 4996193Abstract: The present invention provides formulations for the topical application of cyclosporin to skin tissue for treatment of autoimmune, T-cell mediated immune disease, and inflammatory conditions, and for producing prolonged skin allograft survival and wound healing. In addition, methods for the use of said formulations--in tandem with systemic applications of cyclosporin or without same--are suggested. The present invention also suggests alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions, and further suggests a model with which formulations may be tested.Type: GrantFiled: March 3, 1989Date of Patent: February 26, 1991Assignee: The Regents of the University of CaliforniaInventors: Charles W. Hewitt, Kirby S. Black
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Patent number: 4994374Abstract: This invention relates to a method of diagnosing cancerous diseases, which comprises measuring the amount of UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-transferase in body fluid and evaluating the increase in its amount for the diagnosis of hepatic diseases.AFP, CEA and .gamma.-glutamyltranspeptidase have hitherto been used as tumor markers for the diagnosis of hepatic cancer. But these conventional tumor markers show a positivity rate of about 60%, making early diagnosis almost impossible.The method of this invention employs UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyltransferase as tumor marker, whereby early diagnosis of hepatic cancer can be made almost completely.Type: GrantFiled: May 1, 1989Date of Patent: February 19, 1991Assignee: Oriental Yeast Co., Ltd.Inventors: Atsushi Nishikawa, Naoyuki Taniguchi, Isamu Takagahara
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Patent number: 4990336Abstract: A multiphasic sustained release injectable delivery system is provided, as well as a method for treating humans and other mammals with that multiphasic sustained release system.Type: GrantFiled: February 8, 1989Date of Patent: February 5, 1991Assignee: BioSearch, Inc.Inventors: Loui J. Silvestri, H. Ruth Pyle
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Patent number: 4990537Abstract: An antiviral agent which comprises a p-guanidinobenzoic acid derivative of the formula: ##STR1## wherein R is ##STR2## or its non-toxic salt as an active ingredient.Type: GrantFiled: June 21, 1989Date of Patent: February 5, 1991Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Akira Okuyama, Akira Someya, Takashi Murai, Nobuo Tanaka
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Patent number: 4988806Abstract: Derivatives of carboxymethylcellulose are disclosed in which all or a portion of the carboxymethyl groups are replaced by groups of the general formula ##STR1## in which R.sup.1 is a hydrogen or methyl group,R.sup.2 is a divalent aliphatic hydrocarbon group with 2 to 5 carbon atoms,R.sup.3, R.sup.4 are alkyl groups with 1 to 4 carbon atoms,R.sup.5 is an alkyl group with 1 to 4 carbon atoms or a benzyl group,X is a halogen or sulfate group or a sulfonic acid group,with the proviso that, on the average, at least 0.1 quaternary ammonium groups are contained per anhydroglucose unit of the polymeric molecule.The invention furthermore relates to derivatives of carboxymethylcellulose, in which all or a portion of the carboxymethyl groups are replaced by groups of the general formula ##STR2## in which the substituents R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the above meaning, with the proviso that, on the average, at least 0.Type: GrantFiled: June 13, 1989Date of Patent: January 29, 1991Assignee: Th. Goldschmidt AGInventors: Burghard Gruning, Klaus Hoffmann, Gotz Koerner, Hans-Joachim Kollmeier
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Patent number: 4988678Abstract: The antitumor activity of 5-fluorouracil and its precursors against adenocarcinomas can be potentiated without a corresponding increase in toxicity by combining these compounds with (E)-5-(2-bromovinyl)-uracil or a precursor thereof. The combinations may have the form of a single composition or two separate compositions.Type: GrantFiled: June 29, 1989Date of Patent: January 29, 1991Assignee: Stichting Rega VZWInventors: Erik De Clercq, Masaaki Iigo
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Patent number: 4983401Abstract: A sustained-release pharmaceutical preparation utilizing a pH controlled diffusion membrane composed of a pH sensitive film-forming polymer. The film forming polymer may be an enteric polymer containing phthalic acid with one carboxyl group attached to the enteric polymer via an ester bond, and the second carboxyl group remaining a free acid so that the modified film forming polymer is hydrophobic at low pH and hydrophilic at higher pH. Hydrophobic stearyl side chains are attached to the enteric polymer which causes the pH controlled diffusion membrane to remain insoluble at high pH. Alternatively, the pH sensitive film forming polymer may be a polymer containing hydrophobic and free acid groups so that the modified film forming polymer is hydrophobic at low pH and hydrophilic but insoluble at high pH.Type: GrantFiled: May 22, 1989Date of Patent: January 8, 1991Assignee: Kinaform Technology, Inc.Inventors: Herman J. Eichel, Brent D. Massmann
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Patent number: 4977178Abstract: Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.Type: GrantFiled: July 19, 1989Date of Patent: December 11, 1990Assignee: Pfizer Inc.Inventors: Harry R. Howard, Jr., Reinhard Sarges
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Patent number: 4970300Abstract: Disclosed are conjugates of a protein having antihemophilic factor (Factor VIII) activity linked to nonantigenic ligands. The conjugates have longer half life than the unconjugated protein but maintain substantial Factor VIII activity.Type: GrantFiled: January 18, 1989Date of Patent: November 13, 1990Assignee: New York UniversityInventors: Anne J. Fulton, Alan J. Johnson