Patents Examined by G. Steven Vanni
  • Patent number: 11602635
    Abstract: A computer implemented system and method facilitates a cycle of generation, sharing, and refinement of volumes related to stimulation of anatomical tissue, such as brain or spinal cord stimulation. Such volumes can include target stimulation volumes, side effect volumes, and volumes of estimated activation. A computer system and method also facilitates analysis of groups of volumes, including analysis of differences and/or commonalities between different groups of volumes.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: March 14, 2023
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Hemant Bokil, Stephen Carcieri, Keith R. Carlton, Michael A. Moffitt, Peter J. Yoo
  • Patent number: 11591649
    Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: February 28, 2023
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Matthew Hill, Bernhard Zimmermann, Johan Baner, George Gemelos, Milena Banjevic, Allison Ryan, Styrmir Sigurjonsson, Zachary Demko
  • Patent number: 11589760
    Abstract: This disclosure relates generally to physiological monitoring, and more particularly to feature set optimization for classification of physiological signal. In one embodiment, a method for physiological monitoring includes identifying clean physiological signal training set from an input physiological signal based on a Dynamic Time Warping (DTW) of segments associated with the physiological signal. An optimal features set is extracted from a clean physiological signal training set based on a Maximum Consistency and Maximum Dominance (MCMD) property associated with the optimal feature set that strictly optimizes on the objective function, the conditional likelihood maximization over different selection criteria such that diverse properties of different selection parameters are captured and achieves Pareto-optimality. The input physiological signal is classified into normal signal components and abnormal signal components using the optimal features set.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: February 28, 2023
    Assignee: Tata Consultancy Services Limited
    Inventors: Arijit Ukil, Soma Bandyopadhyay, Chetanya Puri, Rituraj Singh, Arpan Pal, Debayan Mukherjee
  • Patent number: 11587643
    Abstract: In one aspect, a method is disclosed wherein an artificial intelligence (AI) enabled automated flow synthesis platform is configured to generate optimized synthesizing recipes which enable a sequence to be synthesized using an automated flow process. The method includes receiving a synthesizing recipe including parameters used during the automated flow process to synthesize the sequence, receiving spectral data from detectors monitoring the automated flow process in a reaction chamber, where the spectral data corresponds to a reaction point in the automated flow process, and determining, based on indicators associated with the spectral data, characteristics of a chemical reaction at the reaction point in the automated flow process. An artificial intelligence engine determines the chemical reaction. The method includes associating, based on the spectral data, the synthesizing recipe with the chemical reaction.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: February 21, 2023
    Assignee: Peptilogics, Inc.
    Inventors: Francis Lee, Jonathan D. Steckbeck, Hannes Holste
  • Patent number: 11580413
    Abstract: Systems and methods for timing recovery in DNA storage systems is described. In one embodiment, the present systems and methods include generating a unique pattern of DNA bases and use the unique pattern for a phase-locked loop (PLL) field of a data layout, generating a multidimensional mapping, configuring the multidimensional mapping to include one or more prohibited sequences of DNA bases, identifying a prohibited sequence from the multidimensional mapping and use the prohibited sequence for one or more synch-mark (SM) fields of the data layout, prohibiting a User Data field from using any of the prohibited sequences of DNA bases when converting binary data to DNA bases, identifying random insertion and/or deletion of DNA bases in the User Data field, and repairing the random insertion and/or deletion of DNA bases in the User Data field.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: February 14, 2023
    Assignee: SEAGATE TECHNOLOGY LLC
    Inventor: Mehmet Fatih Erden
  • Patent number: 11576972
    Abstract: Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage form. The high quality evaluation is realized by performing peak assignment of a target fingerprint obtained from a chromatogram to a reference fingerprint with high accuracy.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: February 14, 2023
    Assignee: Tsumura & Co.
    Inventors: Yoshikazu Mori, Keiichi Noda
  • Patent number: 11579151
    Abstract: The current invention reports a method for producing an antibody comprising the steps of a) providing a plurality of hybridoma cells each expressing an antibody, b) determining the time dependent amount of said antibody bound to the respective antigen by surface plasmon resonance at different temperatures and different antibody concentrations, c) calculating with the time dependent amount determined in b) based on equations (II) to (XIII) at least the thermodynamic parameters (i) standard association binding entropy (?S°‡ass), (ii) standard dissociation binding entropy (?S°‡diss), (iii) standard binding entropy (?S°), (iv) free standard binding enthalpy (?G°), (v) standard dissociation free binding enthalpy (?G°‡diss), (vi) standard association free binding enthalpy (?G°‡ass), (vii) ?T?S°, (viii) dissociation rate constant kd, (ix) equilibrium binding constant KD, and (x) association rate constant ka, d) selecting a hybridoma cell producing an antibody with at least two of the following: i) a standard associa
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: February 14, 2023
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Michael Schraeml, Leopold Von Proff
  • Patent number: 11581065
    Abstract: Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: February 14, 2023
    Assignee: Clear Labs, Inc.
    Inventors: Sasan Amini, Ramin Khaksar, Michael Taylor, Shadi Shokralla, Christopher Haney, Pavan Vaidyanathan, Stephanie Pollard, Adam Allred, Sima Mortazavi, David Tran, Hossein Namazi, Julius Barsi
  • Patent number: 11574088
    Abstract: This disclosure relates to a computer assistant for a surgeon with a graphical representation of a dynamic knee score for a knee surgery. A processor receives computer tomography data of a current patient's knee and user input from the surgeon, the user input comprises an identifier of a knee implant. The processor then retrieves multiple machine learning model parameters indicative of a machine learning performed on historical patient records. For multiple values of a rotation of the tibial component and a slope of the tibial component the processor configures a post-operative kinematic model performs a kinematic simulation and estimates a current patient outcome by applying the machine learning model. Finally, the processor generates a shaded surface spanning the multiple values of a rotation of the tibial component and a slope of the tibial component on a user interface to graphically represent the estimated current patient outcome for each of the rotation and slope.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: February 7, 2023
    Assignee: 360 KNEE SYSTEMS PTY LTD.
    Inventor: Bede O'Connor
  • Patent number: 11574722
    Abstract: Embodiments provide physiological measurement systems, devices and methods for continuous health and fitness monitoring. A wearable strap may detect reflected light from a user's skin, where data corresponding to the reflected light is used to automatically and continually determine a heart rate of the user. The wearable strap may monitor heart rate data including heart rate variability, resting heart rate, and sleep quality. The systems may include a processing module that generates an indicator of physical recovery based on the heart rate data. The recovery indicator may be used to determine strain related to an exercise routine, qualitative information on the user's health, whether to alter a user's exercise plan, and so forth.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: February 7, 2023
    Assignee: Whoop, Inc.
    Inventors: William Ahmed, John Capodilupo, Aurelian Nicolae
  • Patent number: 11574701
    Abstract: A computer-executable application receives genetic test results for a genetic test a patient has undergone, an identifier for the genetic test, and an identifier for the genetic laboratory that performed the genetic test. The application identifies a format type of the genetic test results. When the format type is unstructured, the application performs an optical character recognition process to the genetic test results such that the format type of the genetic test results is semi-structured. When the format type is semi-structured, the application identifies a set of lexing and parsing rules assigned to the genetic test. The application generates processed genetic test results by applying the set of lexing and parsing rules to the genetic test results and stores the processed genetic test results in a data store. When the format type is structured, the application stores the genetic test results as the processed genetic test results in the data store.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: February 7, 2023
    Assignee: ALLSCRIPTS SOFTWARE, LLC
    Inventors: Yuval Lieberman, Peter DeVries, Dan Alon, Scott Sumner
  • Patent number: 11573182
    Abstract: Some embodiments of the methods provided herein relate to sample analysis and particle characterization methods for large, multi-parameter data sets. Frequency difference gating compares at least two different data sets to identify regions in a multivariate space where a frequency of events from a first data set is different than a frequency of events from the second data set according to a defined threshold.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: February 7, 2023
    Assignee: FlowJo, LLC
    Inventors: Mario Roederer, Michael D. Stadnisky
  • Patent number: 11567063
    Abstract: Disclosed is a method for selecting a cancer treatment regimen for a subject.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 31, 2023
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Ariosto S. Silva, Zayar P. Khin
  • Patent number: 11567089
    Abstract: The present invention relates to clinical decision support systems. In detail, the present invention relates to a method for determining the initial fibrinogen concentration in a biological sample, to the use of fibrinogen added to a biological sample in at least one predetermined concentration, to a device for determining the initial fibrinogen concentration in a biological sample, to a computer program comprising program code means for causing a computer to carry out at least several steps of the method according to the invention, to a computer readable non-transitory storage medium containing instructions for carrying out at least some steps of the method according to the invention, and to a kit for determining the initial fibrinogen concentration in a biological sample.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 31, 2023
    Assignee: Koninklijke Philips N.V.
    Inventors: Hendrik Jan Van Ooijen, Bart Jacob Bakker, Rene Van Den Ham
  • Patent number: 11562257
    Abstract: Techniques for identifying missing evidence are provided. A plurality of documents, each comprising digitally encoded natural language text data, is received. The plurality of documents is processed to determine a plurality of pair-wise comparisons between a plurality of therapies, where each of the plurality of pair-wise comparisons indicate a relative efficacy of at least one therapy in the plurality of therapies, as compared to at least one other therapy in the plurality of therapies. A knowledge graph is generated based at least in part on aggregating the plurality of pair-wise comparisons, and the knowledge graph is analyzed to identify one or more knowledge gaps within the knowledge graph. Finally, at least an indication of the identified one or more knowledge gaps is output.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: January 24, 2023
    Assignee: MERATIVE US L.P.
    Inventors: Richard J. Stevens, Fernando Jose Suarez Saiz, Eric W. Will, Adam Clark
  • Patent number: 11549876
    Abstract: An apparatus and method for determining an amount of chemical input, and more particularly to an apparatus and method for determining the amount of a chemical to be added, which is necessary to achieve target water quality, wherein a required chemical concentration can be accurately calculated based on the temperature of the water and the target turbidity of the water includes an information-receiving unit configured to receive at least one of environmental information, chemical information, and water-quality information of the water present in a specific area and a chemical input determination unit configured to derive a multiple regression equation based on the received environmental information, chemical information, and water-quality information and to determine the future input of a chemical that is added to satisfy a target turbidity of the water present in the specific area based on the multiple regression equation.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: January 10, 2023
    Assignee: DOOSAN ENERBILITY CO., LTD.
    Inventors: Seongjoon Kim, Jungwon Park, Youngkyu Lee
  • Patent number: 11550939
    Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: January 10, 2023
    Assignee: TWIST BIOSCIENCE CORPORATION
    Inventors: Bill James Peck, Ramsey Ibrahim Zeitoun
  • Patent number: 11545238
    Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of a reference protein structure, e.g., an antibody epitope or a protein binding site. A Machine Learning (ML) model is trained by labeling blueprint records generated from a reference target structure with scores calculated based on computational protein modeling of polypeptide structures generated by the blueprint records. The method may include training an ML model based on a first set of blueprint records, or representations thereof, and a first set of scores, each blueprint record from the first set of blueprint records associated with each score from the first set of scores. After the training, the machine learning model may be executed to generate a second set of blueprint records. A set of engineered polypeptides are then generated based on the second set of blueprint records.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: January 3, 2023
    Assignee: IBIO, INC.
    Inventors: Matthew P. Greving, Alexander T. Taguchi, Kevin E. Hauser
  • Patent number: 11542543
    Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: January 3, 2023
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Patent number: 11540757
    Abstract: Presented is a system and method for assessing the functional ability of a person to perform a task. The system comprises: a task identification unit adapted to identify the task to be performed by the person; and a task complexity unit adapted to obtain a task-specific complexity signal representative of a required level of functional ability to perform the identified task. A functional ability unit is adapted to obtain a functional ability signal representative of a determined functional ability of the person. An assessment unit is adapted to determine an ability of the person to perform the identified task based on the task-specific complexity signal and the functional ability signal.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: January 3, 2023
    Assignee: Koninklijke Philips N.V.
    Inventors: Maarten Petrus Joseph Kuenen, Murtaza Bulut, Charles Frederik Sio, Ronaldus Maria Aarts, Chaitanya Dongre